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Themed collection The Mechanics of Supramolecular Chemistry

55 items
Open Access Perspective

Activatable molecular agents for cancer theranostics

Activatable molecualr agents that intergrate diagnosis and treatment modalities have attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome.

Graphical abstract: Activatable molecular agents for cancer theranostics
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Minireview

Shapeshifting molecules: the story so far and the shape of things to come

This review describes the synthesis and application of shapeshifting molecules, whose covalent skeletons dynamically reconfigure in response to their surroundings.

Graphical abstract: Shapeshifting molecules: the story so far and the shape of things to come
From the themed collection: The Mechanics of Supramolecular Chemistry
Review Article

Design and applications of metal-based molecular receptors and probes for inorganic phosphate

We discuss and review the strategies of metal-based receptors targeting phosphate.

Graphical abstract: Design and applications of metal-based molecular receptors and probes for inorganic phosphate
From the themed collection: The Mechanics of Supramolecular Chemistry
Review Article

Supramolecular materials based on AIE luminogens (AIEgens): construction and applications

This review presents comprehensive discussions on the recent development in supramolecular materials based on luminogens with aggregation-induced emission (AIE) characteristics.

Graphical abstract: Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Review Article

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

We review recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. These sensors and imaging agents (probes) are important in biology, physiology, pharmacology, and environmental science.

Graphical abstract: Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Tutorial Review

Molecular logic gates: the past, present and future

Molecular logic gates, now with more than two decades of collective exploration, are poised for practical applications.

Graphical abstract: Molecular logic gates: the past, present and future
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets.

Graphical abstract: Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Aggregation induced emission (AIE) active 4-amino-1,8-naphthalimide-Tröger's base for the selective sensing of chemical explosives in competitive aqueous media

The 4-amino-1,8-naphthalimide Tröger's base based AIE-active supramolecular scaffold was synthesized and employed as a highly selective and sensitive fluorescent sensor for nitroaromatic explosives sensing in competitive aqueous media.

Graphical abstract: Aggregation induced emission (AIE) active 4-amino-1,8-naphthalimide-Tröger's base for the selective sensing of chemical explosives in competitive aqueous media
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

A new naphthalimide based NADH mimic that functions as a fully reversible fluorescent “on off” probe for redox state has been synthesised and evaluated.

Graphical abstract: A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state
From the themed collection: The Mechanics of Supramolecular Chemistry
Accepted Manuscript - Communication

Bio-inspired assembly in phospholipid bilayer: Effective regulation of electrostatic and hydrophobic interaction for plasma membrane specific probes

From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Crown ether-appended calix[2]triazolium[2]arene as a macrocyclic receptor for the recognition of the H2PO4 anion

We report the synthesis of a crown ether-appended calix[2]triazolium[2]arene receptor that shows excellent selectivity for H2PO4 and the binding ability and mode of the receptor to H2PO4 were demonstrated by 1H NMR studies and DFT calculation.

Graphical abstract: Crown ether-appended calix[2]triazolium[2]arene as a macrocyclic receptor for the recognition of the H2PO4− anion
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

A 2,3-dialkoxynaphthalene-based naphthocage

A 2,3-dialkoxynaphthalene-based naphthocage was synthesized. It shows similarly strong binding affinity to organic cations as the 2,6-dialkoxynaphthalene-based naphthocage but different guest preference and conformational response.

Graphical abstract: A 2,3-dialkoxynaphthalene-based naphthocage
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

A fluorogenic probe for tracking GSH flux in developing neurons

We have developed an ultrasensitive assay for GSH in order to help uncover its role in neuronal development.

Graphical abstract: A fluorogenic probe for tracking GSH flux in developing neurons
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS).

Graphical abstract: Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Nanomolar detection of adenosine triphosphate (ATP) using a nanostructured fluorescent chemosensing ensemble

A simple nanostructured chemosensing ensemble for fluorescent turn-on sensing of ATP in aqueous solutions and inside living cells using the indicator displacement assay (IDA) method results in a very low detection limit of 6.8 nM.

Graphical abstract: Nanomolar detection of adenosine triphosphate (ATP) using a nanostructured fluorescent chemosensing ensemble
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

A fluorogenic 2D material has been developed for the imaging of PROCR, a potential biomarker for triple-negative breast cancer.

Graphical abstract: Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Supramolecular chirality of coordination polymers of Ag+ with a chiral thiol ligand that bears a β-turn structure

The coordination polymers of Ag+ with a β-turn containing chiral thiol ligand exhibit supramolecular chirality showing simultaneously the majority rules effect (MRE) and racemate rules effect (RRE).

Graphical abstract: Supramolecular chirality of coordination polymers of Ag+ with a chiral thiol ligand that bears a β-turn structure
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Receptors for sulfate that function across a wide pH range in mixed aqueous–DMSO media

Water soluble macrocyclic squaramides bind selectively to sulfate in aqueous–DMSO mixtures across a pH range from 3.2–14.

Graphical abstract: Receptors for sulfate that function across a wide pH range in mixed aqueous–DMSO media
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

Herein, we exemplify BODIPY-βgal as a ratiometric light-up NIR probe for the quantitative sensing of endogenous β-gal distribution in living cells, and real-time tracking of β-gal activity in tumor-bearing nude mice.

Graphical abstract: In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

“Turn-on” fluorescence sensing of volatile organic compounds using a 4-amino-1,8-naphthalimide Tröger's base functionalised triazine organic polymer

The 4-amino-1,8-naphthalimide Tröger's base functionalized triazine covalent organic polymer was synthesised and employed as a “turn-on” fluorescent sensor for the discriminative sensing of volatile organic compounds (VOCs).

Graphical abstract: “Turn-on” fluorescence sensing of volatile organic compounds using a 4-amino-1,8-naphthalimide Tröger's base functionalised triazine organic polymer
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

A water-soluble dual-site fluorescent probe for the rapid detection of cysteine with high sensitivity and specificity

A water-soluble turn-on fluorescent probe has been developed for the rapid, sensitive and specific detection of Cys.

Graphical abstract: A water-soluble dual-site fluorescent probe for the rapid detection of cysteine with high sensitivity and specificity
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

A probe for imaging of mitochondrial carboxylesterase and pH has been developed for the visualization of carboxylesterase-mediated acidification in hepatoma cells and hepatic tissues during the administration of antipyretic and anti-inflammatory drugs.

Graphical abstract: Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

We developed a small molecule CDr15, which has eDNA selectivity of bacterial biofilm.

Graphical abstract: Visualizing biofilm by targeting eDNA with long wavelength probe CDr15
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

A colorimetric and fluorescent lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food

A colorimetric and fluorogenic sensor exhibiting rapid, specific and sensitive detection of potentially toxic nitrite in food is described.

Graphical abstract: A colorimetric and fluorescent lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

A reversibly mechanochromic conjugated polymer

A reversibly mechanochromic conjugated polymer, based on the thermal polymerization of a diphenyldisulfide-containing bisdiacetylene, was developed.

Graphical abstract: A reversibly mechanochromic conjugated polymer
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Adjustable chiral self-sorting and self-discriminating behaviour between diamond-like Tröger's base-linked cryptands

Adjustable chiral self-sorting and self-discriminating behaviour between diamond-like Tröger's base-linked cryptands was reported, which could be regulated by external stimuli easily.

Graphical abstract: Adjustable chiral self-sorting and self-discriminating behaviour between diamond-like Tröger's base-linked cryptands
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

Shape-persistent pyrrole-based covalent organic cages: synthesis, structure and selective gas adsorption properties

Pyrrole based organic cages for selective CO2 capture.

Graphical abstract: Shape-persistent pyrrole-based covalent organic cages: synthesis, structure and selective gas adsorption properties
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin

A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin.

Graphical abstract: A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

A naphthalimide-based ratiometric fluorescent probe was designed for sensing (and inhibitor screening) of pathogenic bacterial glucosyltransferases associated with the formation of dental caries.

Graphical abstract: Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

NAG-targeting fluorescent probe for sensing proximal tubule cells in patient's crude urine and precision diagnosis for kidney injury unit.

Graphical abstract: NAG-targeting fluorescence based probe for precision diagnosis of kidney injury
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

A naphthoimidazolium-cholesterol derivative as a ratiometric fluorescence based chemosensor for the chiral recognition of carboxylates

We report a naphthoimidazolium-cholesterol derivative (NI-chol 1) as a fluorescence based chemosensor for chiral recognition via imidazolium (C–H)+–anion binding.

Graphical abstract: A naphthoimidazolium-cholesterol derivative as a ratiometric fluorescence based chemosensor for the chiral recognition of carboxylates
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

An ESIPT-based ‘AND’ logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO ‘AND’ biological thiols.

Graphical abstract: ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

ESIPT-based ratiometric fluorescence probe for the intracellular imaging of peroxynitrite

In this work, we set out to develop an ER directed ESIPT-based ONOO ratiometric fluorescent probe (ABAH-LW).

Graphical abstract: ESIPT-based ratiometric fluorescence probe for the intracellular imaging of peroxynitrite
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO)

ESIPT-based fluorescence probes are emerging as an attractive tool for the detection of biologically relevant analytes owing to their unique photophysical properties.

Graphical abstract: ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO−)
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

‘AND’-based fluorescence scaffold for the detection of ROS/RNS and a second analyte

A novel fluorescence-based scaffold was developed enabling the production of ‘AND’ based fluorescence probes – ROS/RNS and a second analyte.

Graphical abstract: ‘AND’-based fluorescence scaffold for the detection of ROS/RNS and a second analyte
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death.

Graphical abstract: A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols

Two ‘turn on’ TCF-based fluorescence probes were developed for the detection of biological thiols (TCF-GSH and TCFCl-GSH).

Graphical abstract: Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Supramolecular glyco-poly-cyclodextrin functionalized thin-layer manganese dioxide for targeted stimulus-responsive bioimaging

A fluorogenic 2D glycoprobe based on poly-cyclodextrin and thin-layer manganese dioxide has been developed for the targeted and stimulus-responsive imaging of cancer cells.

Graphical abstract: Supramolecular glyco-poly-cyclodextrin functionalized thin-layer manganese dioxide for targeted stimulus-responsive bioimaging
From the themed collection: The Mechanics of Supramolecular Chemistry
Communication

A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

Imaging active PPIases in live cells with a small molecular probe.

Graphical abstract: A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Communication

Fluorescence detection and removal of copper from water using a biobased and biodegradable 2D soft material

We have developed a green and robust fluorogenic (λex = 410 nm, λem = 510 nm) cellulose membrane using graphene oxide (GO) as a construct for simultaneous copper ion recognition and filtration at environmentally relevant levels.

Graphical abstract: Fluorescence detection and removal of copper from water using a biobased and biodegradable 2D soft material
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Letter

ESIPT-based fluorescence probe for the ratiometric detection of superoxide

A simple ESIPT-based fluorescence probe (HMBT-LW) was developed for the detection of superoxide (O2˙).

Graphical abstract: ESIPT-based fluorescence probe for the ratiometric detection of superoxide
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Accepted Manuscript - Edge Article

Accurate chiral pattern recognition for amines, albeit a single chemosensor

From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates

DNA–nanoparticle conjugates can be synthesized with independent control over size, valence and elemental composition using a template-based strategy.

Graphical abstract: Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes

Herein, we report a protein-based hybridization strategy that exploits the host–guest chemistry of HSA (human serum albumin) to solubilize the otherwise cell impermeable ONOO fluorescent probe Pinkment-OAc.

Graphical abstract: Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+

Two endoplasmic reticulum (ER) targeting probes were developed to image mobile Zn2+ to help understand Zn2+ related biological processes in the ER.

Graphical abstract: Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Theranostic nanoprobes (SYL NPs) prepared from a newly designed NIR-II fluorophore and FDA approved DSPE-mPEG5000 were well tolerated and exhibited multifunctional potential in diagnosis (photoacoustic & fluorescence imaging) and phototherapy in animal models.

Graphical abstract: Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery

The tumour switches on the NIR-AZA emission for fluorescence guided surgery.

Graphical abstract: RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe

Probe C7 for the first time presents different modes of fluorescence signals to both nanomolar and micromolar concentrations of HOCl.

Graphical abstract: Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH

We have developed a novel AND logic based fluorescence probe for the simultaneous detection of ONOO and GSH (GSH-PF3).

Graphical abstract: The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH
From the themed collection: The Mechanics of Supramolecular Chemistry
Paper

Fluorimetric naphthalimide-based polymer logic beads responsive to acidity and oxidisability

Naphthalimide tagged polymer beads demonstrate two-input H+, Fe3+-driven PASS 0, PASS 1, TRANSFER(H+) and AND logic functions by a fluorescence output.

Graphical abstract: Fluorimetric naphthalimide-based polymer logic beads responsive to acidity and oxidisability
From the themed collection: The Mechanics of Supramolecular Chemistry
Paper

An alternative modular ‘click-SNAr-click’ approach to develop subcellular localised fluorescent probes to image mobile Zn2+

A modular ‘bottom to top’ synthesis of organelle targeted small molecule fluorescent probes for the detection of mobile zinc.

Graphical abstract: An alternative modular ‘click-SNAr-click’ approach to develop subcellular localised fluorescent probes to image mobile Zn2+ 
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Paper

Coumarin-based fluorescent ‘AND’ logic gate probes for the detection of homocysteine and a chosen biological analyte

With this research we set out to develop of a number of coumarin-based ‘AND’ logic fluorescence probes that were capable of detecting a chosen analyte in the presence of HCys.

Graphical abstract: Coumarin-based fluorescent ‘AND’ logic gate probes for the detection of homocysteine and a chosen biological analyte
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Paper

Voltammetric characterisation of diferrocenylborinic acid in organic solution and in aqueous media when immobilised into a titanate nanosheet film

Diferrocenylborinic acid (Fc2BOH, 1) has been synthesized.

Graphical abstract: Voltammetric characterisation of diferrocenylborinic acid in organic solution and in aqueous media when immobilised into a titanate nanosheet film
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Paper

Multiphoton fluorescence lifetime imaging microscopy (FLIM) and super-resolution fluorescence imaging with a supramolecular biopolymer for the controlled tagging of polysaccharides

A new coumarin-appended boronate ester for fluorogenic imaging which binds polysaccharides in solution and in cells.

Graphical abstract: Multiphoton fluorescence lifetime imaging microscopy (FLIM) and super-resolution fluorescence imaging with a supramolecular biopolymer for the controlled tagging of polysaccharides
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Paper

Azulenes with aryl substituents bearing pentafluorosulfanyl groups: synthesis, spectroscopic and halochromic properties

Azulenes with SF5-containing substituents gave significantly different spectroscopic responses to protonation depending on the regioisomer in question.

Graphical abstract: Azulenes with aryl substituents bearing pentafluorosulfanyl groups: synthesis, spectroscopic and halochromic properties
From the themed collection: The Mechanics of Supramolecular Chemistry
55 items

About this collection

The Mechanics of Supramolecular chemistry refers to the underlying “physical organic chemistry” of the field. This collection of works, Guest Edited by Professor Tony James, Professor Jonathan Sessler and Professor Bruce Gibb, was conceived to celebrate the 60th Birthday of Eric V Anslyn who has been an inspiration to countless minds working on solving the fundamental science behind supramolecular chemistry.

”My childhood was filled with repairing and constructing mechanical entities, such as internal combustion motors, where many components work together to achieve a function. Analogously, the field of supramolecular chemistry creates systems of high complexity that achieve functions or perform tasks. Therefore, in retrospect a career in supramolecular chemistry appears to be simply an extension of childhood hobbies”
Eric V Anslyn - Beilstein J Org Chem. 2016; 12: 362–376.

Articles in this themed collection will be added below as soon as possible after they are published.

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