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Issue 24, 2019
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Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

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Abstract

We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.

Graphical abstract: Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

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Supplementary files

Article information


Submitted
17 Jan 2019
Accepted
25 Feb 2019
First published
25 Feb 2019

This article is Open Access

Chem. Commun., 2019,55, 3548-3551
Article type
Communication

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

L. Feng, Q. Yan, B. Zhang, X. Tian, C. Wang, Z. Yu, J. Cui, D. Guo, X. Ma and T. D. James, Chem. Commun., 2019, 55, 3548
DOI: 10.1039/C9CC00440H

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