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Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates

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Abstract

DNA–nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we report a novel, bottom-up approach for the synthesis of DNA–nanoparticle conjugates, based on ring-opening metathesis polymerization (ROMP), intramolecular crosslinking, and template synthesis. Using size, valence, and elemental composition as three independent synthetic parameters, various conjugates can be obtained using a facile and universal procedure. Examples are given to show the usefulness of these conjugates as sensing probes, building blocks for self-assembly, and as model particles for structure–property relationship studies.

Graphical abstract: Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates

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Article information


Submitted
07 Nov 2019
Accepted
31 Dec 2019
First published
02 Jan 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Advance Article
Article type
Edge Article

Independent control over size, valence, and elemental composition in the synthesis of DNA–nanoparticle conjugates

Y. Bai, H. Xing, Y. Bai, L. H. Tan, K. Hwang, J. Li, Y. Lu and S. C. Zimmerman, Chem. Sci., 2020, Advance Article , DOI: 10.1039/C9SC05656D

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