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Issue 13, 2019
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NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

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Abstract

We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-D-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.

Graphical abstract: NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

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Supplementary files

Article information


Submitted
31 Dec 2018
Accepted
14 Jan 2019
First published
14 Jan 2019

This article is Open Access

Chem. Commun., 2019,55, 1955-1958
Article type
Communication

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

F. Yan, X. Tian, Z. Luan, L. Feng, X. Ma and T. D. James, Chem. Commun., 2019, 55, 1955
DOI: 10.1039/C8CC10311A

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