Issue 32, 2020
From the journal:

Chemical Communications

Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model†

Yan Wang,ab   Feifei Yu,b   Xianzhu Luo,ab   Mingshun Li,ab   Linlu Zhao*b  and  Fabiao Yu ORCID logo *ab  

* Corresponding authors

a The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China

b Institute of Functional Materials and Molecular Imaging, Key Laboratory of Emergency and Trauma, Ministry of Education, College of Pharmacy, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Clinical Medicine, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China
E-mail: fbyu@yic.ac.cn, zhaolinlu@hainmc.edu.cn

Abstract

We establish a near-infrared two-photon fluorescent probe for the detection of CE2 with high selectivity and sensitivity. This probe exhibits low cytotoxicity and superior tissue penetration ability for evaluating the real-time activity of CE2 in living cells, in cancer tissues, and in a colon carcinoma mice model.

Graphical abstract: Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model

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Article information

DOI
https://doi.org/10.1039/D0CC00297F
Article type
Communication
Submitted
12 Jan 2020
Accepted
09 Mar 2020
First published
09 Mar 2020

Chem. Commun., 2020,56, 4412-4415

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Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model

Y. Wang, F. Yu, X. Luo, M. Li, L. Zhao and F. Yu, Chem. Commun., 2020, 56, 4412 DOI: 10.1039/D0CC00297F

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