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Issue 88, 2019
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Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

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Abstract

Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

Graphical abstract: Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

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Article information


Submitted
18 Aug 2019
Accepted
20 Sep 2019
First published
02 Oct 2019

This article is Open Access

Chem. Commun., 2019,55, 13235-13238
Article type
Communication

Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

W. Dou, L. Liu, J. Gao, Y. Zang, G. Chen, R. A. Field, T. D. James, J. Li and X. He, Chem. Commun., 2019, 55, 13235
DOI: 10.1039/C9CC06399D

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