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Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

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Abstract

Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

Graphical abstract: Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

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Publication details

The article was received on 18 Aug 2019, accepted on 20 Sep 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06399D
Chem. Commun., 2019, Advance Article
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    Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

    W. Dou, L. Liu, J. Gao, Y. Zang, G. Chen, R. A. Field, T. D. James, J. Li and X. He, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06399D

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