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Issue 44, 2018
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A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

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Abstract

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D–π–A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

Graphical abstract: A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

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Supplementary files

Article information


Submitted
23 Mar 2018
Accepted
09 Apr 2018
First published
11 Apr 2018

This article is Open Access

Chem. Commun., 2018,54, 5518-5521
Article type
Communication

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

L. Wu, Y. Wang, T. D. James, N. Jia and C. Huang, Chem. Commun., 2018, 54, 5518
DOI: 10.1039/C8CC02330A

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    [Original citation] - Published by The Royal Society of Chemistry.

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