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Issue 80, 2018
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ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

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Abstract

An ESIPT-based ‘AND’ logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO and biological thiols. GSH-ABAH was shown to have good cell permeability and with the addition of just SIN-1 (ONOO donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO ‘AND’ GSH added to RAW264.7 cells.

Graphical abstract: ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

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Supplementary files

Article information


Submitted
25 Aug 2018
Accepted
11 Sep 2018
First published
11 Sep 2018

This article is Open Access

Chem. Commun., 2018,54, 11336-11339
Article type
Communication

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

L. Wu, H. Han, L. Liu, J. E. Gardiner, A. C. Sedgwick, C. Huang, S. D. Bull, X. He and T. D. James, Chem. Commun., 2018, 54, 11336
DOI: 10.1039/C8CC06917D

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