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Issue 82, 2019
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In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

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Abstract

Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of β-galactosidase (β-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous β-gal activity in SKOV-3 cells and tumor-bearing mice.

Graphical abstract: In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

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Article information


Submitted
03 Sep 2019
Accepted
19 Sep 2019
First published
19 Sep 2019

Chem. Commun., 2019,55, 12308-12311
Article type
Communication

In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

L. Shi, C. Yan, Y. Ma, T. Wang, Z. Guo and W. Zhu, Chem. Commun., 2019, 55, 12308
DOI: 10.1039/C9CC06869D

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