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Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model

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Abstract

We establish a near-infrared two-photon fluorescent probe for the detection of CE2 with high selectivity and sensitivity. This probe exhibits low cytotoxicity and superior tissue penetration ability for evaluating the real-time activity of CE2 in living cells, in cancer tissues, and in a colon carcinoma mice model.

Graphical abstract: Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model

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Article information


Submitted
12 Jan 2020
Accepted
09 Mar 2020
First published
09 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model

Y. Wang, F. Yu, X. Luo, M. Li, L. Zhao and F. Yu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00297F

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