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Activatable molecular agents for cancer theranostics

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Abstract

Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics.

Graphical abstract: Activatable molecular agents for cancer theranostics

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Publication details

The article was received on 30 Oct 2019, accepted on 22 Nov 2019 and first published on 22 Nov 2019


Article type: Perspective
DOI: 10.1039/C9SC05460J
Chem. Sci., 2020, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Activatable molecular agents for cancer theranostics

    J. Zhang, L. Ning, J. Huang, C. Zhang and K. Pu, Chem. Sci., 2020, Advance Article , DOI: 10.1039/C9SC05460J

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