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Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

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Abstract

Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.

Graphical abstract: Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

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Publication details

The article was received on 03 Oct 2019, accepted on 05 Nov 2019 and first published on 02 Dec 2019


Article type: Communication
DOI: 10.1039/C9CC07759F
Chem. Commun., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

    B. L. Patenall, G. T. Williams‡, L. Gwynne, L. J. Stephens, E. V. Lampard, H. J. Hathaway, N. T. Thet, A. E. Young, M. J. Sutton, R. D. Short, S. D. Bull, T. D. James, A. C. Sedgwick and A. T. A. Jenkins, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07759F

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