Issue 100, 2019

Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Abstract

Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.

Graphical abstract: Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Supplementary files

Article information

Article type
Communication
Submitted
03 Oct 2019
Accepted
05 Nov 2019
First published
02 Dec 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 15129-15132

Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

B. L. Patenall, G. T. Williams‡, L. Gwynne, L. J. Stephens, E. V. Lampard, H. J. Hathaway, N. T. Thet, A. E. Young, M. J. Sutton, R. D. Short, S. D. Bull, T. D. James, A. C. Sedgwick and A. T. A. Jenkins, Chem. Commun., 2019, 55, 15129 DOI: 10.1039/C9CC07759F

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