Themed collection Celebrating 100 Years of Chemistry at Nankai University
DNA nanostructure-based nucleic acid probes: construction and biological applications
In recent years, DNA has been widely noted as a kind of material that can be used to construct building blocks for biosensing, in vivo imaging, drug development, and disease therapy because of its advantages of good biocompatibility and programmable properties.
Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
This review summarizes the applications of grafted semiconducting polymer amphiphiles (SPAs) as multimodal optical nanoagents for cancer imaging and combination phototherapy.
Electrodeposition of (hydro)oxides for an oxygen evolution electrode
This minireview looks at recent electrodeposition strategies for metal (hydro)oxide design and water oxidation applications, unveiling the unique properties and underlying principles of electrodeposited metal (hydro)oxides in the OER.
Developing better ester- and ether-based electrolytes for potassium-ion batteries
A comprehensive summary on how to optimize ester- and ether-based electrolytes for high-performance potassium-ion batteries.
Asymmetric synthesis of N–N axially chiral compounds via organocatalytic atroposelective N-acylation
A highly efficient atroposelective N-acylation reaction of quinazolinone type benzamides with cinnamic anhydrides for the direct catalytic synthesis of optically active atropisomeric quinazolinone derivatives was developed.
Solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes: access to cyclopentenones and dihydropyranols
A solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes is developed, providing a facile access to sulfonylated cyclopentenones and dihydropyranols under mild conditions.
Diverse protein manipulations with genetically encoded glutamic acid benzyl ester
Herein, we genetically encode an esterified glutamic acid analogue (BnE) into proteins, and demonstrate that BnE can be applied in different types of site-specific protein modifications.
Triarylamine-based porous coordination polymers performing both hydrogen atom transfer and photoredox catalysis for regioselective α-amino C(sp3)–H arylation
The efficiency of photosensitization and hydrogen atom transfer (HAT) catalysis is balanced in a recyclable heterogeneous manner by the modification of the N-central conformation in Cd-MIX.
Asymmetric hydrogenation of exocyclic γ,δ-unsaturated β-ketoesters to functionalized chiral allylic alcohols via dynamic kinetic resolution
An iridium catalyzed asymmetric hydrogenation of exocyclic γ,δ-unsaturated β-ketoesters via dynamic kinetic resolution was developed, providing efficient protocol for enantioselective synthesis of functionalized chiral allylic alcohols.
Non-concentrated aqueous electrolytes with organic solvent additives for stable zinc batteries
Involvement of dimethyl carbonate and trifluoromethanesulfonate anions in a hybrid aqueous electrolyte enables the formation of a new Zn2+-solvation structure and a ZnF2–ZnCO3-rich interphase that stabilizes the Zn battery chemistry.
Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA
A highly efficient and versatile method for construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation of alkyl and aryl thiols with aryl iodides under mild conditions is developed.
Access to P-stereogenic compounds via desymmetrizing enantioselective bromination
A highly efficient desymmetrizing asymmetric bromination of bisphenol phosphine oxides was developed, providing a wide range of chiral bisphenol phosphine oxides and bisphenol phosphinates with high yields and enantioselectivities.
Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester
The catalytic asymmetric Mannich/condensation of glycine ester with aldimines was achieved by merging chiral N,N′-dioxide/YbIII complex Lewis acid catalysis/carbonyl catalysis under mild condition.
A rapid and sensitive method for chiroptical sensing of α-amino acids via click-like labeling with o-phthalaldehyde and p-toluenethiol
A highly practical method for comprehensive chiroptical sensing of free α amino acids with streamlined operation and high sensitivity via dual CD/UV measurements is developed.
Purely organic light-harvesting phosphorescence energy transfer by β-cyclodextrin pseudorotaxane for mitochondria targeted imaging
A new type of purely organic light-harvesting PET supramolecular assembly is constructed with efficient energy transfer and ultrahigh antenna effect. Moreover, the assembly could be used for mitochondria targeted imaging in A549 cancer cells.
Mitigation of Jahn–Teller distortion and Na+/vacancy ordering in a distorted manganese oxide cathode material by Li substitution
Li-Substitution in P′2-Na0.67MnO2 mitigates the anisotropic change of Mn–O bonds and Na/vacancy ordering, and hence significantly promotes its cycling stability and rate capability as a cathode material for sodium-ion batteries.
Aluminum-catalyzed tunable halodefluorination of trifluoromethyl- and difluoroalkyl-substituted olefins
Aluminum-catalyzed halodefluorination reactions of fluoroalkyl-substituted olefins are developed. The reactions can selectively deliver mono-, di-, or trisubstituted products.
Controlling cyclization pathways in palladium(II)-catalyzed intramolecular alkene hydro-functionalization via substrate directivity
We report a series of palladium(II)-catalyzed, intramolecular alkene hydrofunctionalization reactions with carbon, nitrogen, and oxygen nucleophiles to form five- and six-membered carbo- and heterocycles.
Simultaneous manifestation of metallic conductivity and single-molecule magnetism in a layered molecule-based compound
A metallic single-molecule magnet was synthesised demonstrating simultaneous metallic conduction and excellent SMM properties at the same temperature range for the first time, with potential applications in molecule-based quantum spintronics.
Catalytic asymmetric synthesis of quaternary trifluoromethyl α- to ε-amino acid derivatives via umpolung allylation/2-aza-Cope rearrangement
In this study, we developed an efficient Ir-catalyzed cascade umpolung allylation/2-aza-Cope rearrangement for the preparation of a variety of quaternary trifluoromethyl α-ε-amino acids in high yields with excellent enantioselectivities.
Heparin reversal by an oligoethylene glycol functionalized guanidinocalixarene
An oligoethylene glycol functionalized guanidinocalixarene was developed as a safe antidote against heparin, via specific recognition and neutralization of heparin in vitro and in vivo.
Diazaphosphinyl radical-catalyzed deoxygenation of α-carboxy ketones: a new protocol for chemo-selective C–O bond scission via mechanism regulation
Diazaphosphinyl radical-catalyzed chemo-selective deoxygenation of α-carboxy ketones with pinacolborane was achieved through the mechanism switch from direct to stepwise hydride transfer of diazaphosphinane.
Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens
AIEgens are exploited to simultaneously extend the conjugation, boost the brightness, and increase the solubility of organic near-infrared fluorophores, representing a new strategy for developing high-performance emitters for biomedical imaging.
Highly efficient H2S scavengers via thiolysis of positively-charged NBD amines
We demonstrate that positively-charged NBD amines can effectively scavenge biological H2S in live cells and in mice.
BNN-1,3-dipoles: isolation and intramolecular cycloaddition with unactivated arenes
The mono-base-coordinated 1,2-diboranylidenehydrazine derivatives exhibiting the BNN-1,3-dipolar reactivity toward unactivated arenes and CO2 are reported.
Crystal engineering of a rectangular sql coordination network to enable xylenes selectivity over ethylbenzene
[Co(bipy)(bptz)(NCS)2]n, a new mixed-linker sql coordination network, exhibits high xylene adsorption capacity and high xylene selectivity over ethylbenzene (>5).
Supramolecular combination chemotherapy: a pH-responsive co-encapsulation drug delivery system
Most cancer chemotherapy regimens rely on the use of two or more chemotherapeutic agents. A supramolecular approach that may allow co-delivery of two drugs is described here.
Stimulus-responsive surface-enhanced Raman scattering: a “Trojan horse” strategy for precision molecular diagnosis of cancer
A stimulus-responsive surface-enhanced Raman scattering (SR-SERS) technique was developed to selectively profile the comprehensive molecular phenotype of tumor tissues.
Photo-induced carbocation-enhanced charge transport in single-molecule junctions
We report the first example of photo-induced carbocation-enhanced charge transport in triphenylmethane junctions using the scanning tunneling microscopy break junction (STM-BJ) technique.
High-efficiency dynamic sensing of biothiols in cancer cells with a fluorescent β-cyclodextrin supramolecular assembly
A unique fluorescent supramolecular assembly was constructed from coumarin-modified β-cyclodextrin and an adamantane-modified cyclic arginine–glycine–aspartate peptide for high-efficiency real-time monitoring of biothiols in cancer cells.
Diazaphosphinanes as hydride, hydrogen atom, proton or electron donors under transition-metal-free conditions: thermodynamics, kinetics, and synthetic applications
A new 1,3,2-diazaphosphinane, serving as a formal hydride, hydrogen-atom or proton donor without transition-metal mediation was exploited thermodynamically and kinetically. And, its promising potentials in versatile syntheses have been demonstrated.
Counterintuitive solvation effect of ionic-liquid/DMSO solvents on acidic C–H dissociation and insight into respective solvation
The dependence of PhCH(CN)2 pKa on the molar fraction of ionic liquids in ionic–molecular binary mixtures showed a nonlinear three-fragment plot, which was rationalized for the first time by the respective roles of each solvent component for solvation.
Directional molecular sliding movement in peptide hydrogels accelerates cell proliferation
Dynamic peptide hydrogels undergoing directional domain sliding movement upon release of covalent constraint accelerate cell proliferation through a mechanotransduction pathway.
Formyl-selective deuteration of aldehydes with D2O via synergistic organic and photoredox catalysis
Formyl-selective deuteration of aldehydes with D2O mediated by the synergistic combination of light-driven, polyoxometalate-facilitated HAT and thiol catalysis is reported.
Strong dual emission in covalent organic frameworks induced by ESIPT
The introduction of hydroxyl groups and n-butyl groups into COF-4-OH for the construction of COFs with strong dual emission was demonstrated.
Nickel-catalyzed hydroalkylation and hydroalkenylation of 1,3-dienes with hydrazones
Nickel-catalyzed highly regioselective hydroalkylation and hydroalkenylation of dienes were achieved with different hydrazones.
Three-dimensional DNA nanostructures to improve the hyperbranched hybridization chain reaction
Nonenzymatic nucleic acid amplification techniques (e.g. the hybridization chain reaction, HCR) have shown promising potential for amplified detection of biomarkers.
Plasmon-promoted electrocatalytic water splitting on metal–semiconductor nanocomposites: the interfacial charge transfer and the real catalytic sites
The interfacial charge transfer and real catalytic sites on metal–semiconductor hybrid catalysts for photoelectrocatalytic water splitting are studied.
A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates
Photoirradiation of the PC4AP linker generates an active intermediate that reacts intramolecularly with a primary amine on the carrier peptide/protein, leading to rapid release of the drug without generating any toxic side products.
Benchmark selectivity p-xylene separation by a non-porous molecular solid through liquid or vapor extraction
Solid–liquid separation of similarly sized organic molecules utilizing sorbents offers the potential for new energy-efficient approaches to a number of important industrial separations such as xylenes (C8) separations.
Locus-patterned sequence oriented enrichment for multi-dimensional gene analysis
A locus-patterned sequence oriented enrichment was proposed to analyze the gene sequence, locus variation and molecular abundance of heterogeneous genes.
Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids
Transmetalation-initiated three-component vicinal-diarylation of alkenes.
In situ real-time tracing of hierarchical targeting nanostructures in drug resistant tumors using diffuse fluorescence tomography
Nanoparticles that respond to specific endogenous or exogenous stimuli in tumor tissues are actively being developed to address multidrug resistance owing to multiple advantages, including a prolonged circulation time, enhanced permeability and retention effect, and superior cellular uptake.
Ultralong room-temperature phosphorescence of a solid-state supramolecule between phenylmethylpyridinium and cucurbituril
We report an ultralong room-temperature phosphorescence (2.62 s) based on cucurbituril host and phenyl-methyl-pyridinium guest for data encryption. Encapsulation of CB boosts intersystem crossing and suppresses nonradiative relaxation of guest.
Solvent-assisted coordination driven assembly of a supramolecular architecture featuring two types of connectivity from discrete nanocages
A 3D nanocage architecture with two types of connectivity was successfully assembled from discrete supramolecular nanocages.
Laser illumination-induced dramatic catalytic activity change on Au nanospheres
In this work, the distinct catalytic properties of a single gold nanoparticle (GNP) after symmetry breaking were disclosed at the single-particle level for the first time.
Synthesis and structure of a family of rhodium polystannide clusters [Rh@Sn10]3–, [Rh@Sn12]3–, [Rh2@Sn17]6– and the first triply-fused stannide, [Rh3@Sn24]5–
Triply fused cluster: edge shared of three [Rh@Sn10] subunits lead to the largest endohedral polystannide with an entirely new triply fused topology.
Access to P-chiral phosphine oxides by enantioselective allylic alkylation of bisphenols
A biscinchona alkaloid-catalyzed AAA reaction for the construction of P-stereogenic center compounds was developed.
A compatible anode/succinonitrile-based electrolyte interface in all-solid-state Na–CO2 batteries
A compatible anode/succinonitrile-based electrolyte interface is achieved owing to the in situ formed NaF-rich interphase through an extremely simple approach.
Dinuclear HgII tetracarbene complex-triggered aggregation-induced emission for rapid and selective sensing of Hg2+ and organomercury species
Mercury-mediated chelate ring formation and subsequent aggregation gives strong fluorescence for rapid and selective sensing of Hg2+ and organomercury.
Photo-responsive cyclodextrin/anthracene/Eu3+ supramolecular assembly for a tunable photochromic multicolor cell label and fluorescent ink
A photoresponsive supramolecular assembly was constructed and presented multi-color fluorescence emissions in several environments including solution, PVA and living cells.
Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones
A metal-free intramolecular tandem sequence involving alkoxylation, Claisen rearrangement and lactone expansion has been achieved.
An integrated-molecular-beacon based multiple exponential strand displacement amplification strategy for ultrasensitive detection of DNA methyltransferase activity
An ultra-sensitive biosensor using only two DNA oligos to initiate multiple signal amplification cycles.
Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress
Dual-biomarker-triggered fluorescent probes were developed for simultaneous detection of the two biomarkers H2S and hNQO1 in cancer cells.
A nonaqueous potassium-ion hybrid capacitor enabled by two-dimensional diffusion pathways of dipotassium terephthalate
Potassium-ion hybrid capacitor is enabled by fast diffusion, facile reaction kinetics and small volume change of dipotassium terephthalate and its comparability to the non-faradaic capacitive kinetics of activated carbon, and hence shows high power and energy density.
Color-tunable lanthanide metal–organic framework gels
MOF gels with intrinsic emission color are prepared with 5-boronoisophthalic acid and Eu3+, Tb3+, and/or Dy3+. Single-metal gels exhibit trichromatic fluorescence, so full color emissions are readily obtained by tuning the type and/or ratio of Ln3+ ions to prepare mixed-metal gels. Nano-ribbons form from the precursors and then entangle together to generate the gels.
Negative area compressibility of a hydrogen-bonded two-dimensional material
Very few materials expand two-dimensionally under pressure, and this extremely rare phenomenon, namely negative area compressibility (NAC), is highly desirable for technological applications in pressure sensors and actuators.
Single-particle tracking discloses binding-mediated rocking diffusion of rod-shaped biological particles on lipid membranes
Interestingly, on the lipid membrane, E.coli displays anomalous rocking diffusion, which might facilitate the subsequent survey of stronger association sites on the two-dimensional (2D) surface.
Stabilizing nickel-rich layered oxide cathodes by magnesium doping for rechargeable lithium-ion batteries
Magnesium doping in a high-capacity Ni-rich cathode suppresses cation mixing and transition-metal migration, leading to remarkable structural stability and cycling performance.
Visible-light-mediated Minisci C–H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant
Herein, we report a protocol for direct visible-light-mediated Minisci C–H alkylation of heteroarenes with unactivated alkyl halides using molecular oxygen as an oxidant at room temperature.
Photoredox-mediated remote C(sp3)–H heteroarylation of free alcohols
We report an efficient and economical method for remote δ C(sp3)–H heteroarylation of free aliphatic alcohols using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis.
Dalmanol biosyntheses require coupling of two separate polyketide gene clusters
Polyketide–polyketide hybrids are unique natural products with promising bioactivity, but the hybridization processes remain poorly understood.
Manganese(II) phosphate nanosheet assembly with native out-of-plane Mn centres for electrocatalytic water oxidation
Nature selects Mn-clusters as catalysts for water oxidation, which is a significant reaction in photosynthesis.
EDTA etching: a simple way for regulating the traps, size and aqueous-dispersibility of Cr3+-doped zinc gallate
EDTA etching, the first strategy that simply generates deep traps while reducing the size and improving the aqueous-dispersibility, is presented.
Silver-mediated oxidative functionalization of alkylsilanes
A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported.
An “all-in-one” antitumor and anti-recurrence/metastasis nanomedicine with multi-drug co-loading and burst drug release for multi-modality therapy
A simple multi-modality therapy with multi-drug co-loading and burst drug release for a high curative effect and anti-recurrence/metastasis was reported.
Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
The first nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with organoboronic acids are achieved under redox-neutral conditions.
The morphology and surface charge-dependent cellular uptake efficiency of upconversion nanostructures revealed by single-particle optical microscopy
The cellular uptake efficiency of nanostructures has been demonstrated to be highly dependent on the surface charge, size and shape although the cellular internalization process is still far from being well-understood.
Rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes
A novel rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes has been developed, affording the hydroamination and hydroindolation products in good to excellent yields with outstanding ee values through a new TMM–Rh model complex.
Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2
The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported.
About this collection
This year marks the 100th anniversary of chemical sciences at Nankai University. To help celebrate this important milestone and the exceptional research that is synonymous with Nankai University, Chemical Science is co-organising a joint symposium, titled “Celebrating 100 years at Nankai with New Frontiers in Chemistry: A Chemical Science Symposium”, which will feature research that crosses new frontiers and boundaries within the chemical sciences and introduces new concepts. The symposium will be hosted and organised by Professor Shou-Fei Zhu (Nankai University) and Chemical Science Associate Editors Professor Ning Jiao (Peking University) and Professor Jinlong Gong (Tianjin University). This collection accompanies the Symposium, and features Chemical Science articles from authors at Nankai University and speakers of the symposium. We hope you enjoy this selection of articles.
To view an introduction to this collection, please see our blog post.