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Themed collection Analytical Methods Recent Open Access Articles

37 items
Open Access Critical Review

Review of 3D cell culture with analysis in microfluidic systems

A review with 105 references that analyzes the emerging research area of 3D cell culture in microfluidic platforms with integrated detection schemes.

Graphical abstract: Review of 3D cell culture with analysis in microfluidic systems
Open Access Critical Review

Frontiers in electrochemical sensors for neurotransmitter detection: towards measuring neurotransmitters as chemical diagnostics for brain disorders

This critical review highlights significant technical advances and in vivo studies from the last five years that facilitate the development of diagnostic tools for brain disorders.

Graphical abstract: Frontiers in electrochemical sensors for neurotransmitter detection: towards measuring neurotransmitters as chemical diagnostics for brain disorders
Open Access Critical Review

Review: new insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection

The carbon-fiber microelectrode has been used for decades as a neurotransmitter sensor, but many new carbon electrodes have recently been developed with beneficial electrochemical properties that take advantage of surface chemistry and surface structure.

Graphical abstract: Review: new insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection
Open Access Communication

Sheath-flow probe electrospray ionization (sfPESI) mass spectrometry for the rapid forensic analysis of human body fluids

A novel method for the rapid, in situ analysis of fresh and dried human biological materials using sfPESI mass spectrometry.

Graphical abstract: Sheath-flow probe electrospray ionization (sfPESI) mass spectrometry for the rapid forensic analysis of human body fluids
Open Access Communication

Emerging patterns in the global distribution of dissolved organic matter fluorescence

The spectra responsible for natural dissolved organic matter fluorescence in 90 peer-reviewed studies have been compared using new similarity metrics.

Graphical abstract: Emerging patterns in the global distribution of dissolved organic matter fluorescence
Open Access Communication

Measuring elasticity of wet cellulose fibres with AFM using indentation and a linearized Hertz model

The mechanical properties of different pulp fibres in liquid were measured using an atomic force microscope.

Graphical abstract: Measuring elasticity of wet cellulose fibres with AFM using indentation and a linearized Hertz model
Open Access Communication

Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine

Sensitive laser desorption/ionization obtained via a sublimation-coated 1,5 diaminonaphthalene (1,5-DAN) matrix allowed dual polarity MALDI-IMS analysis on the same pixel points across the jejunal mucosa.

Graphical abstract: Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine
Open Access Paper

Investigation of cavitation-induced damage on PDMS films

Traumatic brain injuries (TBIs) are complex phenomena that create epidemic healthcare and financial concerns.

Graphical abstract: Investigation of cavitation-induced damage on PDMS films
Open Access Paper

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

A fast (15 min), accurate and reproducible 1H q-NMR (in D2O) analysis performed on many samples containing complex mixtures of MDMA and NPS revealing significant differences in their ratios.

Graphical abstract: 1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues
Open Access Paper

In situ silanization for continuous stationary phase gradients on particle packed LC columns

This work describes, for the first time, an in situ silanization process for creating phenyl–butyl gradients on particle LC columns.

Graphical abstract: In situ silanization for continuous stationary phase gradients on particle packed LC columns
Open Access Paper

Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator

An efficient twin-trap smoking inhalation model that simulates human inhalation has been developed; all six synthetic cannabinoids tested were detected.

Graphical abstract: Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator
Open Access Paper

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Quantitative nuclear magnetic resonance (q-NMR) spectroscopy is a robust and reliable analytical method that possesses many advantages over conventional chromatographic techniques used in drug analysis.

Graphical abstract: 19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids
Open Access Paper

SERS-based sandwich bioassay protocol of miRNA-21 using Au@Ag core–shell nanoparticles and a Ag/TiO2 nanowires substrate

Based on surface-enhanced Raman scattering (SERS) technology, Au@Ag@4MBA@5′-NH2-ssDNA probes and a Ag/TiO2@3′-NH2-ssDNA substrate were prepared and constructed into a sandwich structure to develop a high sensitivity bioassay of miRNA-21.

Graphical abstract: SERS-based sandwich bioassay protocol of miRNA-21 using Au@Ag core–shell nanoparticles and a Ag/TiO2 nanowires substrate
Open Access Paper

An integrated homogeneous SPARCL™ immunoassay for rapid biomarker detection on a chip

A very simple and rapid homogeneous SPARCL™ immunoassay with on-chip preserved dry reagents enables sensitive quantitative detection of biomarkers.

Graphical abstract: An integrated homogeneous SPARCL™ immunoassay for rapid biomarker detection on a chip
Open Access Paper

A methodology for the fast identification and monitoring of microplastics in environmental samples using random decision forest classifiers

A new yet little understood threat to our ecosystems is microplastics.

Graphical abstract: A methodology for the fast identification and monitoring of microplastics in environmental samples using random decision forest classifiers
Open Access Paper

Validation of alkaline oxidation as a pre-treatment method for elemental quantification in single-walled carbon nanotubes

Certified fractions of Ni, Co and Mo in carbon nanotubes were recovered from a fused borate salt bead and measured with ICP-OES.

Graphical abstract: Validation of alkaline oxidation as a pre-treatment method for elemental quantification in single-walled carbon nanotubes
Open Access Paper

Chemical analysis using 3D printed glass microfluidics

Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally.

Graphical abstract: Chemical analysis using 3D printed glass microfluidics
Open Access Paper

Using castor oil to separate microplastics from four different environmental matrices

An affordable, low-risk and quick method for the separation of microplastics from four environmental matrices based on castor oil.

Graphical abstract: Using castor oil to separate microplastics from four different environmental matrices
Open Access Paper

Chiral micellar electrokinetic chromatographic separation for determination of L- and D-primary amines released from murine islets of Langerhans

A chiral micellar electrokinetic chromatography method developed to investigate D-amino acid secretions from murine islets of Langerhans.

Graphical abstract: Chiral micellar electrokinetic chromatographic separation for determination of l- and d-primary amines released from murine islets of Langerhans
Open Access Paper

Determination of the graphene–graphite ratio of graphene powder by Raman 2D band symmetry analysis

This paper presents a method to distinguish graphene from graphite in powdered samples by analysing the Raman 2D band symmetry.

Graphical abstract: Determination of the graphene–graphite ratio of graphene powder by Raman 2D band symmetry analysis
Open Access Paper

Analytical determination of heroin, fentanyl and fentalogues using high-performance liquid chromatography with diode array and amperometric detection

We report a combination of HPLC and electrochemistry towards the detection of heroin, fentanyl and ten fentalogues.

Graphical abstract: Analytical determination of heroin, fentanyl and fentalogues using high-performance liquid chromatography with diode array and amperometric detection
Open Access Paper

Characterisation of thin boron-doped diamond films using Raman spectroscopy and chemometrics

A non-destructive chemometric method to determine thickness and boron concentration of as-deposited, thin, heavily doped diamond films by Raman microscopy.

Graphical abstract: Characterisation of thin boron-doped diamond films using Raman spectroscopy and chemometrics
Open Access Paper

Chiral analysis of β-methylamino alanine (BMAA) enantiomers after (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) derivatization and LC-MS/MS

A developed method for chiral analysis of neurotoxin β-methylamino alanine (BMAA) allowed detection of D-BMAA in cycad seed samples.

Graphical abstract: Chiral analysis of β-methylamino alanine (BMAA) enantiomers after (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) derivatization and LC-MS/MS
Open Access Paper

Accurate flow in augmented networks (AFAN): an approach to generating three-dimensional biomimetic microfluidic networks with controlled flow

A network augmentation approach that adds synthetic connections to microvascular networks to induce biomimetic microfluidic flow.

Graphical abstract: Accurate flow in augmented networks (AFAN): an approach to generating three-dimensional biomimetic microfluidic networks with controlled flow
Open Access Paper

A study into the ageing and dating of blue ball tip inks on paper using in situ visible spectroscopy with chemometrics

This study used reflectance visible spectroscopy with chemometrics as an in situ ink dating approach for forensic document examination.

Graphical abstract: A study into the ageing and dating of blue ball tip inks on paper using in situ visible spectroscopy with chemometrics
Open Access Paper

Simple lateral flow assays for microbial detection in stool

Minimal sample preparation, amplification-free detection of DNA at the point-of-need.

Graphical abstract: Simple lateral flow assays for microbial detection in stool
Open Access Paper

An improved rapid sampling microdialysis system for human and porcine organ monitoring in a hospital setting

Online organ monitoring can provide clinicians with critical information regarding organ health prior to transplantation and could aid clinical decision-making.

Graphical abstract: An improved rapid sampling microdialysis system for human and porcine organ monitoring in a hospital setting
Open Access Paper

Intra-individual variance of the human plasma oxylipin pattern: low inter-day variability in fasting blood samples versus high variability during the day

Low intra-individual inter-day variance in concentrations of free oxylipins supports the use of fasting plasma for the investigation of oxylipin biology.

Graphical abstract: Intra-individual variance of the human plasma oxylipin pattern: low inter-day variability in fasting blood samples versus high variability during the day
Open Access Paper

Fluorescence signal-to-noise optimisation for real-time PCR using universal reporter oligonucleotides

In this study we optimised the fluorescence signal generation of contact quenched universal reporter oligonucleotides.

Graphical abstract: Fluorescence signal-to-noise optimisation for real-time PCR using universal reporter oligonucleotides
Open Access Paper

Development and comparison of regression models for the determination of quality parameters in margarine spread samples using NIR spectroscopy

More than a hundred margarine samples and their FT-NIR spectra were used to develop regression models, and to compare them with sum of ranking differences and ANOVA.

Graphical abstract: Development and comparison of regression models for the determination of quality parameters in margarine spread samples using NIR spectroscopy
Open Access Paper

Measuring the relative concentration of particle populations using differential centrifugal sedimentation

The factors that affect the accuracy and precision of differential centrifugal sedimentation (DCS) for the analysis of nanoparticle concentration are described.

Graphical abstract: Measuring the relative concentration of particle populations using differential centrifugal sedimentation
Open Access Paper

A novel EI-GC/MS method for the accurate quantification of anti-aging compound oleoylethanolamine in C. elegans

A novel GC-MS method for the quantification of oleoylethanolamine in C. elegans.

Graphical abstract: A novel EI-GC/MS method for the accurate quantification of anti-aging compound oleoylethanolamine in C. elegans
Open Access Paper

Regional feature extraction of various fishes based on chemical and microbial variable selection using machine learning

We introduce a method for extracting regional and habitat features of various fish species based on chemical and microbial correlations that incorporate integrated analysis and a variable selection approach.

Graphical abstract: Regional feature extraction of various fishes based on chemical and microbial variable selection using machine learning
Open Access Paper

Measuring the size and density of nanoparticles by centrifugal sedimentation and flotation

Analytical centrifugation in sedimentation and flotation modes is used to measure both the size and density of polystyrene nanoparticles.

Graphical abstract: Measuring the size and density of nanoparticles by centrifugal sedimentation and flotation
Open Access Paper

Determination of amphetamine-type stimulants (ATSs) and synthetic cathinones in urine using solid phase micro-extraction fibre tips and gas chromatography-mass spectrometry

An optimum condition procedure applied to a SPME PDMS/DVB fiber tip in a mixture of drugs in a urine sample.

Graphical abstract: Determination of amphetamine-type stimulants (ATSs) and synthetic cathinones in urine using solid phase micro-extraction fibre tips and gas chromatography-mass spectrometry
Open Access Paper

Raman spectroscopic library of medieval pigments collected with five different wavelengths for investigation of illuminated manuscripts

Stepwise identification of medieval pigments by Raman spectra data and excitation source.

Graphical abstract: Raman spectroscopic library of medieval pigments collected with five different wavelengths for investigation of illuminated manuscripts
Open Access Paper

A high-throughput method for orthophosphate determination of thermostable membrane-bound pyrophosphatase activity

Membrane-bound pyrophosphatases (mPPases) are homodimeric integral membrane proteins that hydrolyse pyrophosphate into orthophosphates coupled to the active transport of protons or sodium ions across membranes.

Graphical abstract: A high-throughput method for orthophosphate determination of thermostable membrane-bound pyrophosphatase activity
37 items

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This collection features recent open access articles published in Analytical Methods.

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