Themed collection Analytical Methods Recent Open Access Articles

A review with 105 references that analyzes the emerging research area of 3D cell culture in microfluidic platforms with integrated detection schemes.

This critical review highlights significant technical advances and in vivo studies from the last five years that facilitate the development of diagnostic tools for brain disorders.

The carbon-fiber microelectrode has been used for decades as a neurotransmitter sensor, but many new carbon electrodes have recently been developed with beneficial electrochemical properties that take advantage of surface chemistry and surface structure.

A novel method for the rapid, in situ analysis of fresh and dried human biological materials using sfPESI mass spectrometry.

The spectra responsible for natural dissolved organic matter fluorescence in 90 peer-reviewed studies have been compared using new similarity metrics.

The mechanical properties of different pulp fibres in liquid were measured using an atomic force microscope.

Sensitive laser desorption/ionization obtained via a sublimation-coated 1,5 diaminonaphthalene (1,5-DAN) matrix allowed dual polarity MALDI-IMS analysis on the same pixel points across the jejunal mucosa.

Traumatic brain injuries (TBIs) are complex phenomena that create epidemic healthcare and financial concerns.

A fast (15 min), accurate and reproducible ¹H q-NMR (in D₂O) analysis performed on many samples containing complex mixtures of MDMA and NPS revealing significant differences in their ratios.

This work describes, for the first time, an in situ silanization process for creating phenyl–butyl gradients on particle LC columns.

An efficient twin-trap smoking inhalation model that simulates human inhalation has been developed; all six synthetic cannabinoids tested were detected.

Quantitative nuclear magnetic resonance (q-NMR) spectroscopy is a robust and reliable analytical method that possesses many advantages over conventional chromatographic techniques used in drug analysis.

Based on surface-enhanced Raman scattering (SERS) technology, Au@Ag@4MBA@5′-NH₂-ssDNA probes and a Ag/TiO₂@3′-NH₂-ssDNA substrate were prepared and constructed into a sandwich structure to develop a high sensitivity bioassay of miRNA-21.

A very simple and rapid homogeneous SPARCL™ immunoassay with on-chip preserved dry reagents enables sensitive quantitative detection of biomarkers.

A new yet little understood threat to our ecosystems is microplastics.

Certified fractions of Ni, Co and Mo in carbon nanotubes were recovered from a fused borate salt bead and measured with ICP-OES.

Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally.

An affordable, low-risk and quick method for the separation of microplastics from four environmental matrices based on castor oil.

A chiral micellar electrokinetic chromatography method developed to investigate D-amino acid secretions from murine islets of Langerhans.

This paper presents a method to distinguish graphene from graphite in powdered samples by analysing the Raman 2D band symmetry.

We report a combination of HPLC and electrochemistry towards the detection of heroin, fentanyl and ten fentalogues.

A non-destructive chemometric method to determine thickness and boron concentration of as-deposited, thin, heavily doped diamond films by Raman microscopy.

A developed method for chiral analysis of neurotoxin β-methylamino alanine (BMAA) allowed detection of D-BMAA in cycad seed samples.

A network augmentation approach that adds synthetic connections to microvascular networks to induce biomimetic microfluidic flow.

This study used reflectance visible spectroscopy with chemometrics as an in situ ink dating approach for forensic document examination.

Minimal sample preparation, amplification-free detection of DNA at the point-of-need.

Online organ monitoring can provide clinicians with critical information regarding organ health prior to transplantation and could aid clinical decision-making.

Low intra-individual inter-day variance in concentrations of free oxylipins supports the use of fasting plasma for the investigation of oxylipin biology.

In this study we optimised the fluorescence signal generation of contact quenched universal reporter oligonucleotides.

More than a hundred margarine samples and their FT-NIR spectra were used to develop regression models, and to compare them with sum of ranking differences and ANOVA.

The factors that affect the accuracy and precision of differential centrifugal sedimentation (DCS) for the analysis of nanoparticle concentration are described.

A novel GC-MS method for the quantification of oleoylethanolamine in C. elegans.

We introduce a method for extracting regional and habitat features of various fish species based on chemical and microbial correlations that incorporate integrated analysis and a variable selection approach.

Analytical centrifugation in sedimentation and flotation modes is used to measure both the size and density of polystyrene nanoparticles.

An optimum condition procedure applied to a SPME PDMS/DVB fiber tip in a mixture of drugs in a urine sample.

Stepwise identification of medieval pigments by Raman spectra data and excitation source.

Membrane-bound pyrophosphatases (mPPases) are homodimeric integral membrane proteins that hydrolyse pyrophosphate into orthophosphates coupled to the active transport of protons or sodium ions across membranes.