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Issue 3, 2019
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Review: new insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection

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Abstract

The carbon-fiber microelectrode has been used for decades as a neurotransmitter sensor. Recently, new strategies have been developed for making carbon electrodes, including using carbon nanomaterials or pyrolyzing a photoresist etched by nanolithography or 3D printing. This review summarizes how chemical and 3D surface structures of new carbon electrodes are optimized for neurotransmitter detection. There are effects of the chemical structure that are advantageous, and nanomaterials are used ranging from carbon nanotubes (CNTs) to graphene to nanodiamond. Functionalization of these materials promotes surface oxide groups that adsorb dopamine, and dopants introduce defect sites good for electron transfer. Polymer coatings such as poly(3,4-ethylenedioxythiophene) (PEDOT) or Nafion also enhance the selectivity, particularly for dopamine over ascorbic acid. Changing the 3D surface structure of an electrode increases the current by adding more surface area. If the surface structure has roughness or pores on the micron scale, the electrode also acts as a thin layer cell, momentarily trapping the analyte for redox cycling. Vertically aligned CNTs as well as lithographically made or 3D printed pillar arrays act as thin layer cells, producing more reversible cyclic voltammograms. A better understanding of how the chemical and surface structure affects the electrochemistry enables rational design of electrodes. New carbon electrodes are being tested in vivo and strategies to reduce biofouling are being developed. Future studies should test the robustness for long term implantation, explore electrochemical properties of neurotransmitters beyond dopamine, and combine optimized chemical and physical structures for real-time monitoring of neurotransmitters.

Graphical abstract: Review: new insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection

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Publication details

The article was received on 12 Nov 2018, accepted on 18 Dec 2018 and first published on 21 Dec 2018


Article type: Critical Review
DOI: 10.1039/C8AY02472C
Anal. Methods, 2019,11, 247-261
  • Open access: Creative Commons BY-NC license
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    Review: new insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection

    Q. Cao, P. Puthongkham and B. J. Venton, Anal. Methods, 2019, 11, 247
    DOI: 10.1039/C8AY02472C

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