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Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator

Abstract

Synthetic cannabinoids are a major class of NPS with a high impact on analytical, forensic and toxicological fields. The main route of administration of synthetic cannabinoids is through inhalation, delivered by smoking a conventional or electronic cigarette, pyrolysis possibly altering the nature of these compounds and resulting in unknown combustion products with unknown biological activity/toxicology. In this study, a twin-trap smoking inhalation model that simulates human inhalation has been developed. The smoking simulator allows the efficient trapping of the combustion products. Analysis using UHPLC/TOF-ESI-MS and GC/MS allowed the detection of all six synthetic cannabinoids tested in the smoking simulator. A novel combustion product of MDMB-CHMICA was identified, a dihydro-1H-pyridoindole-dione with its structure and mechanism of formation proposed. This study of SC combustion products provides markers which may be useful for drug analysts and toxicologists in examining samples obtained from suspected SC users/abusers.

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Supplementary files

Publication details

The article was received on 05 Apr 2019, accepted on 07 May 2019 and first published on 07 May 2019


Article type: Paper
DOI: 10.1039/C9AY00722A
Anal. Methods, 2019, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator

    H. A. Naqi, C. R. Pudney, S. Husbands and I. S. Blagbrough, Anal. Methods, 2019, Accepted Manuscript , DOI: 10.1039/C9AY00722A

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