Issue 13, 2019

Chemical analysis using 3D printed glass microfluidics


Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 μm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.

Graphical abstract: Chemical analysis using 3D printed glass microfluidics

Supplementary files

Article information

Article type
03 Sep 2018
19 Feb 2019
First published
14 Mar 2019
This article is Open Access
Creative Commons BY license

Anal. Methods, 2019,11, 1802-1810

Chemical analysis using 3D printed glass microfluidics

E. Gal-Or, Y. Gershoni, G. Scotti, S. M. E. Nilsson, J. Saarinen, V. Jokinen, C. J. Strachan, G. Boije af Gennäs, J. Yli-Kauhaluoma and T. Kotiaho, Anal. Methods, 2019, 11, 1802 DOI: 10.1039/C8AY01934G

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