Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Brian Pecson and Daniel Gerrity present an Editorial Perspective which focuses on the impact of SARS-CoV-2 on the water industry.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Vincenzo Naddeo and Haizhou Liu present an ‘Editorial Perspective’ on coronavirus in wastewater and discuss the water research needs to combat viral outbreaks.
Soft matter science and the COVID-19 pandemic
Much of the science underpinning the global response to the COVID-19 pandemic lies in the soft matter domain.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Ultraviolet germicidal irradiation is one method for decontamination of N-95 filtering facepiece respirators to facilitate reuse during the COVID-19 pandemic. Other techniques include hydrogen peroxide vaporization, microwave-generated steaming, and dry heating.
Trends and targets in antiviral phototherapy
With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Multiplex lateral flow immunoassays for outstanding POCT of infectious diseases.
Novel biosensing methodologies for ultrasensitive detection of viruses
Biosensors function as rapid, sensitive and specific diagnostic tools for various viral infectious diseases.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Recent developments in the biological activities of polyoxometalates (metal-oxide cluster anions) are discussed from the chemotherapeutic point of view for a novel inorganic drug.
Diagnostic technologies for COVID-19: a review
Summary of the latest research progress on detection methods of SARS-CoV-2, providing a reference to develop rapid and accurate diagnostic strategies for COVID-19.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Since the coronaviruses that cause COVID-19 and SARS-CoV-1 share 80% structural similarity, we present a comprehensive review of the diverse molecular inhibitors of SARS-CoV-1. This will help to accelerate drug discovery for deadly coronavirus diseases.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
A schematic representation of different methods to inhibit SARS-CoV-2 infection.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Potential drug candidates derived from natural sources are posed for the development of anti-SARS CoV-2 therapeutics.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Herpes Simplex Virus type 1 (HSV-1) is a nuclear replicating enveloped virus.
Antiviral drug discovery: broad-spectrum drugs from nature
Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.
Influenza neuraminidase: A druggable target for natural products
This review covers the increasing research efforts of the past decade, focusing on the structure, function and druggability of influenza NA, and its inhibition by natural products. Latest developments in theoretical and experimental research on NA for lead discovery strategies from nature are presented.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
This review provides a comprehensive look at whether a pandemic enveloped virus would pose challenges for the wastewater and drinking water industries.
The role of biosensors in the detection of emerging infectious diseases
An ideal approach to real-time disease detection and surveillance.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Unveiling the nanomechanical stability of the novel coronavirus (SARS-CoV-2) spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Using a combination of enhanced sampling molecular dynamics techniques and non-equilibrium alchemical transformations, we have shown that hydroxychloroquine may act as a mild inhibitor of important functional proteins for SARS-CoV2 replication.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Multicolor silver nanoparticles enable multiplexed detection of dengue, yellow fever, and Ebola virus proteins in a single lateral flow strip.
Inhibition of SARS coronavirus helicase by bismuth complexes
The SARS-CoV NTPase/helicase being able to unwind both RNA and DNA duplexes, is an attractive target for anti-viral drug design. A series of bismuth complexes were synthesized and characterized, and exhibit the inhibition against the SARS helicase ATPase and duplex-unwinding activities at micromolar concentrations.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The polymer polyphosphate, abundant in blood platelets, blocks the binding of the receptor-binding domain (RBD) of the SARS- spike (S)-protein to the angiotensin-converting enzyme 2 (ACE2) at low concentrations.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
COVID-19 has been declared as a global health emergency and exposed the world to a deadly virus, which has dramatically changed the lives of humans for an unknown period of time.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Development of a microfluidic disc-direct reverse-transcription quantitative PCR platform to perform automated multiplex nucleic acid tests for rapid multiplex detection of disease infection.
A modular microarray imaging system for highly specific COVID-19 antibody testing
The TinyArray imager, a robust inexpensive portable imaging device, can detect antibodies against SARS-CoV-2 based on coronavirus antigen microarrays.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
There has been a strong and urgent demand to diagnose community transmission-driven coronavirus disease 2019 (COVID-19) after it crossed borders. Tablet PC-based portable device for colorimetric determination and 3D printed sample holders.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
SARS-CoV-2 is a novel coronavirus that was first identified during the outbreak in Wuhan, China in 2019.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The significant role of curcumin against SARS-CoV-2 drug targets to thwart virus replication and binding into the host system using the computational biology paradigm approach.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Simultaneous inhibition of silver–carbene complexes to ACE2 and PDB6LU7 is conducive for the prevention of SARS-CoV-2 infection: a virtual prediction.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Galectin 3 have the potential to inhibit the SARS-CoV-2 spike protein. We validated the studies by docking, MD and MM/GBSA calculations.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A commercially-available UV disinfection system used for hospital room disinfection was characterized and used for N95 filtering facepiece respirator (FFR) material disinfection.
A facile assay for rapid detection of COVID-19 antibodies
The preparation principle and the result interpretation of COVID-19 antibody rapid detection strip.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Since the outbreak of Coronavirus disease (COVID-19) caused by SARS-CoV-2 in December 2019, there has been no vaccine or specific antiviral medication for treatment of the infection where supportive care and prevention of complications is the current management strategy.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Conformational changes in the remdesivir-bound RdRP leading to its inhibition.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
As part of a global effort to identify drug candidates for the treatment of COVID-19, herein, we report small molecules commercially available selected from a consensus virtual screening strategy.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
SARS-CoV-2 3CLpro shows homology in binding to an aza-peptide epoxide (APE) known for the irreversible inhibition of main peptidase in SARS-CoV.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
Anti-HIV drug repurposing against SARS-CoV-2
A novel severe acute respiratory syndrome human coronavirus (SARS HCoV) was identified from respiratory illness patients (named SARS-CoV-2 by ICTV) in December 2019 and has recently emerged as a serious threat to world public health.
Length-scale dependence of protein hydration-shell density
An increase in protein hydration-shell density relative to that of the bulk is observed (in the range of 4–14%) for all studied proteins and this density-increment, which decreases for decreasing protein size, is caused by the protein size only.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Mercaptoethane sulfonate functionalised Te/BSA nanostars are prepared and exhibit excellent antiviral activity against arteriviruses and coronaviruses.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The polymerase chain reaction (PCR) has unique advantages of sensitivity, specificity and rapidity in pathogen detection, which makes it at the forefront of academia and application in molecular biology diagnosis.
An electrophoretic DNA extraction device using a nanofilter for molecular diagnosis of pathogens
A simple electrophoretic DNA extraction device has developed using a nanofilter for rapid and efficient DNA aquisition required for point-of-care analysis in order to prevent an epidemic/pandemic disease outbreak.
A structure-free digital microfluidic platform for detection of influenza a virus by using magnetic beads and electromagnetic forces
A new type of digital microfluidic platform for influenza A H1N1 virus detection by utilizing a one-aptamer/two-antibodies assay on magnetic beads was reported.
A sample-to-answer, portable platform for rapid detection of pathogens with a smartphone interface
A smartphone-controlled, automated, and portable system was developed for rapid molecular diagnosis of pathogens via the use of a colorimetric loop-mediated isothermal amplification (LAMP) approach on a passive, self-driven microfluidic device.
Semi-automatic instrumentation for nucleic acid extraction and purification to quantify pathogens on surfaces
A semi-automated detection system compatible with PCR that can detect infectious pathogens on wide surfaces in a short time.
A chip-based potentiometric sensor for a Zika virus diagnostic using 3D surface molecular imprinting
The high sensitivity and high selectivity demonstrated here proved that this lab-on-a-chip diagnostic has the potential to become a point-of-care (POC) detection system for rapid and accurate screening of flaviviruses.
Rapid immunodiagnostics of multiple viral infections in an acoustic microstreaming device with serum and saliva samples
There is a need to screen multiple infections simultaneously rather than one infection at a time to improve the quality of healthcare.
Integration of a 3D-printed read-out platform with a quantum dot-based immunoassay for detection of the avian influenza A (H7N9) virus
Outbreaks and potential epidemics of the highly pathogenic avian influenza virus pose serious threats to human health and the global economy.
Visual detection of Zika virus by isothermal nucleic acid amplification combined with a lateral-flow device
The Zika virus (ZIKV) did not receive significant attention in the past until the ZIKV outbreak occurred a few years ago.
An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR
A microfluidic chip featuring HA × NA arrayed reaction chambers for RT-PCR was developed for diagnosis and subtyping of influenza A viruses.
An integrated device for the rapid and sensitive detection of the influenza hemagglutinin
We demonstrate the swab-to-result detection of influenza virus using a novel paper microfluidic device. This device incorporates computationally designed affinity proteins with enzymatic amplification for improved sensitivity and specificity.
Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method
We developed a real-time colorimetric method based on LAMP-integrated microfluidic chip system for diagnosing multiple respiratory viruses.
Synthesis and antiviral activity of novel spirocyclic nucleosides
A diverse range of spirocyclic nucleosides have been prepared from a common precursor and tested for their antiviral activity.
A hand-held device for rapid single tube detection of hepatitis-C virus
A Single Tube Analysis system using LAMP, LED and ION-sensing (STALLION) for pathogen derived RNA/DNA.
High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice
Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting in hospitalization.
Sensitive and rapid detection of pathogenic bacteria from urine samples using multiplex recombinase polymerase amplification
Multiple detection of pathogenic bacteria from urine samples was achieved on a centrifugal microfluidic chip using RPA.
Nanoparticle-enhanced electrical detection of Zika virus on paper microchips
Zika virus (ZIKV) is a reemerging flavivirus causing an ongoing pandemic and public health emergency worldwide. We developed nanoparticle-enhanced sensing of virus lysate for electrical detection of ZIKV on paper microchip.
A fully-integrated and automated testing device for PCR-free viral nucleic acid detection in whole blood
Integrated devices for automated nucleic acid testing (NAT) are critical for infectious disease diagnosis to be performed outside of centralized laboratories.
Rapid and sensitive detection of viral nucleic acids using silicon microchips
Rapid and sensitive amplification of viral nucleic acids is feasible on a flexible silicon microchip technology platform.
Understanding the viral load during the synthesis and after rebinding of virus imprinted particles via real-time quantitative PCR
In the present study, virus imprinted particles have been synthesized for recognizing and specifically binding viruses.
Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity
Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.
About this collection
All Royal Society of Chemistry articles on coronavirus research can be found here and are freely available.