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Issue 1, 2015
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Antiviral drug discovery: broad-spectrum drugs from nature

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Abstract

Covering: up to April 2014

The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with scepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent of new and more powerful screening assays and prediction tools, the idea of a drug that can efficiently treat a wide range of viral infections by blocking specific host functions has re-bloomed. Here we critically review the state-of-the-art in broad-spectrum antiviral drug discovery. We discuss putative targets and treatment strategies, with particular focus on natural products as promising starting points for antiviral lead development.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature

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Article information


Submitted
18 Jun 2014
First published
15 Oct 2014

Nat. Prod. Rep., 2015,32, 29-48
Article type
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

J. P. Martinez, F. Sasse, M. Brönstrup, J. Diez and A. Meyerhans, Nat. Prod. Rep., 2015, 32, 29
DOI: 10.1039/C4NP00085D

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