Harindi Jayakody, Guy Kiddle, Semali Perera, Laurence Tisi and Hannah S. Leese
Anal. Methods, 2021,13, 3744-3763
DOI:
10.1039/D1AY00947H,
Critical Review
As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and understanding the epidemiology of this disease. A plethora of technologies have enabled the diagnosis of individuals, informed clinical management, aided population-wide screening to determine transmission rates and identified cases within the wider community and high-risk settings. This review explores the application of molecular diagnostics technologies in controlling the spread of COVID-19, and the key factors that affect the sensitivity and specificity of the tests used.