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Issue 45, 2020
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Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

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Abstract

The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection. About 10 million people are already infected, about 500 000 deaths all over the world to date. Great efforts have been made to find solutions for this viral infection, either vaccines, monoclonal antibodies, or small molecule drugs; this can stop the spread of infection to avoid the expected human, economic and social catastrophe associated with this infection. In the literature and during clinical trials in hospitals, several FDA approved drugs for different diseases have the potential to treat or reduce the severity of COVID-19. Repurposing of these drugs as potential agents to treat COVID-19 reduces the time and cost to find effective COVID-19 agents. This review article summarizes the present situation of transmission, pathogenesis and statistics of COVID-19 in the world. Moreover, it includes chemistry, mechanism of action at the molecular level of the possible drug molecules which are liable for redirection as potential COVID-19 therapeutic agents. This includes polymerase inhibitors, protease inhibitors, malaria drugs, lipid lowering statins, rheumatoid arthritis drugs and some miscellaneous agents. We offer research data and knowledge about the chemistry and biology of potential COVID-19 drugs for the research community in this field.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

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Article information


Submitted
03 Jul 2020
Accepted
08 Jul 2020
First published
17 Jul 2020

This article is Open Access

RSC Adv., 2020,10, 26895-26916
Article type
Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

G. E. A. Abuo-Rahma, M. F. A. Mohamed, T. S. Ibrahim, M. E. Shoman, E. Samir and R. M. Abd El-Baky, RSC Adv., 2020, 10, 26895
DOI: 10.1039/D0RA05821A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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