Advances in mass spectrometry based single-cell metabolomics
Single cell metabolomics using mass spectrometry can contribute to understanding biological activities in health and disease.
How iMALDI can improve clinical diagnostics
Protein mass spectrometry (MS) is an indispensable tool to detect molecular signatures that can be associated with cellular dysregulation and disease.
Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells
This review summarizes recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells.
Recent advances in the chemical imaging of human fingermarks (a review)
This review highlights the considerable advances in the chemical imaging of human fingermarks. Additional information about the donor can be obtained from the chemical composition of latent fingermarks besides the physical pattern, such as the age, gender, medical history and possible drug habits.
Recent advancements in ion concentration polarization
Advancements in ion concentration polarization made over the past three years are highlighted.
Electrochemical hydrogen sulfide biosensors
Biological application of electrochemical hydrogen sulfide sensors.
Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics
We present an overview of current isolation, detection, and characterization methods of extracellular vesicles and their applications and limitations as a potential emerging biomarker in cancer management and their clinical implementation.
Thin film depth profiling by ion beam analysis
The analysis of thin films is of central importance for functional materials, including the very large and active field of nanomaterials.
High spatial and temporal resolution cell manipulation techniques in microchannels
Reviewing latest developments on lab on chips for enhanced control of cells’ experiments.
Gold nanoparticles as sensitive optical probes
Recent advances in Au NP based optical sensing systems for various analytes based on absorption, fluorescence and SERS are summarized.
Review: a comprehensive summary of a decade development of the recombinase polymerase amplification
RPA is a versatile complement or replacement of PCR, and now is stepping into practice.
Hybrid plasmonic–photonic whispering gallery mode resonators for sensing: a critical review
In this review we present the state of the art and the most recent advances in the field of optical sensing with hybrid plasmonic–photonic whispering gallery mode (WGM) resonators.
A critical insight into the development pipeline of microfluidic immunoassay devices for the sensitive quantitation of protein biomarkers at the point of care
A critical review on the development of microfluidic tests capable of the high-sensitivity measurement of protein biomarkers at the point-of-care.
Chemometrics for ion mobility spectrometry data: recent advances and future prospects
This is the first comprehensive review on chemometric techniques used in ion mobility spectrometry data analysis.
Nanoparticles and intracellular applications of surface-enhanced Raman spectroscopy
Surface-enhanced Raman spectroscopy offers ultra-sensitive vibrational fingerprinting within biological cells.
Raman spectroscopy: an evolving technique for live cell studies
This review highlights some of the most recent advances in the development of Raman spectroscopy for live cell studies.
Functionalization of metal nanoclusters for biomedical applications
Metal nanoclusters (NCs) are emerging as a new class of functional nanomaterials in the area of biological sensing, labelling, imaging and therapy due to their unique physical and chemical properties, such as ultrasmall size, HOMO–LUMO transition, strong luminescence together with good photostability and biocompatibility.
Micro-scale spatially offset Raman spectroscopy for non-invasive subsurface analysis of turbid materials
This article reviews a very recent field of noninvasive analysis of turbid media using micro-scale Spatially Offset Raman Spectroscopy – micro-SORS.
Biomarker detection technologies and future directions
Advancement in technologies which can provide highly selective and sensitive multiplex detection of biomarkers is inevitable for accurate disease prognosis, diagnosis, and treatment follow-up.
Determination of cellular vitamin C dynamics by HPLC-DAD
A redox-sensitive inter-conversion between ascorbic acid (ASC) and its oxidized form dehydroascorbic acid (DHA) in the intracellular environment has been of exceptional interest to recent metabolomics and pharmaceutical research.
Capillary photoionization: interface for low flow rate liquid chromatography-mass spectrometry
The first report on capillary photoionization interfacing a liquid chromatograph and mass spectrometer.
Quantifying cyanide in water and foodstuff using corrin-based CyanoKit technologies and a smartphone
This paper describes the detection of endogenous cyanide using corrin-based CyanoKit technologies in combination with a smartphone readout device.
Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers
The first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of methoxphenidine (MXP) and its regioisomers.
Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)
A novel analytical approach for the identification/quantification of the reduction products of platinum(IV) complexes is presented.
Bulk double emulsification for flow cytometric analysis of microfluidic droplets
We describe a simple bulk method to prepare double emulsions for high-throughput analysis and sorting with flow cytometers.
10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy
Nanoslits with a depth of ∼10 nm were manufactured on a germanium internal reflection element for attenuated internal reflection infrared spectroscopy.
Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system
A quantitative method based on image analysis of multiple color changes in microfluidic paper-based analytical devices using CIE L*a*b* color difference is presented.
Next generation of labeling reagents for quantitative and multiplexing immunoassays by the use of LA-ICP-MS
A novel labeling strategy – which results in one label per antibody molecule – was used for multiplex and quantitative immuno imaging by use of LA-ICP-MS.
Advanced gas sensors based on substrate-integrated hollow waveguides and dual-color ring quantum cascade lasers
The first combination of a ring-shaped vertically emitting quantum cascade laser (riQCL) with a substrate-integrated hollow waveguide (iHWG) is presented.
Infrared spectroscopy via substrate-integrated hollow waveguides: a powerful tool in catalysis research
Monitoring catalyst performance via substrate-integrated hollow waveguide (iHWGs) assisted infrared spectroscopy.
Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors
Using Surface Enhanced Raman Spectroscopy to measure cell death caused by radiation in a 3D model of prostate cancer.
A tunable Au core–Ag shell nanoparticle tip for tip-enhanced spectroscopy
A single Au nanoparticle (NP) with a diameter of 5 nm was transferred to the end of a Si-tip through a picking process, and an Ag shell with a controlled thickness was formed on the Au core.
Detection of prostate cancer using a voltammetric electronic tongue
A multivariate analysis of data from urine with an electronic voltammetric tongue to detect patients with prostate cancer.
Electrocatalytic monitoring of peptidic proton-wires
The transfer of protons or proton donor/acceptor abilities is an important phenomenon in many biomolecular systems.
Signal enhancement in ligand–receptor interactions using dynamic polymers at quartz crystal microbalance sensors
The signal enhancement properties of QCM sensors based on dynamic, biotinylated poly(acrylic acid) brushes has been studied in interaction studies with an anti-biotin Fab fragment.
NMR detection in biofluid extracts at sub-μM concentrations via para-H2 induced hyperpolarization
A combination of solid phase extraction, para-hydrogen induced hyperpolarization and selective NMR detection allows the quantitative determination of a doping substance at sub-μM concentrations in urine.
The origin of the band at around 730 cm−1 in the SERS spectra of bacteria: a stable isotope approach
A stable isotope approach combined with SERS analysis of bacteria allows clarification of the origin of a pronounced band at 730 cm−1.
Analytically useful blue chemiluminescence from a water-soluble iridium(III) complex containing a tetraethylene glycol functionalised triazolylpyridine ligand
The first highly water soluble, blue-luminescent iridium(III) complex for chemiluminescence detection is presented.
Utilising copper screen-printed electrodes (CuSPE) for the electroanalytical sensing of sulfide
A mediatorless sulfide electrochemical sensing platform utilising a novel nanocopper-oxide screen-printed electrodes (CuSPE) is reported for the first time.
A ratiometric fluorescent probe for detection of biogenic primary amines with nanomolar sensitivity
An ultrasensitive ratiometric fluorescent sensor made of an N,N-dimethylaminonaphthalene anhydride moiety for detection of aliphatic primary amines is reported.
A novel label-free terbium(III)-aptamer based aptasensor for ultrasensitive and highly specific detection of acute lymphoma leukemia cells
Acute leukemia is a malignant clonal disease of hematopoietic stem cells with a high prevalence and mortality rate.
Direct monitoring of light mediated hyperthermia induced within mammalian tissues using surface enhanced spatially offset Raman spectroscopy (T-SESORS)
Here we demonstrate light mediated heating of nanoparticles confined deep inside mammalian tissue, whilst directly monitoring their temperature non-invasively using a form of deep Raman spectroscopy, T-SESORS.
Screening of two-photon activated photodynamic therapy sensitizers using a 3D osteosarcoma model
An in vitro screening platform for high-throughput profiling and comparison of two-photon photodynamic therapy sensitizers was established.
Sensitive CVG-AFS/ICP-MS label-free nucleic acid and protein assays based on a selective cation exchange reaction and simple filtration separation
Sensitive CVG-AFS/ICP-MS label-free nucleic acid and protein assays based on a selective cation exchange reaction and simple filtration separation.
Fast screening of illicit drugs in beverages and biological fluids by direct coupling of thin film microextraction to dielectric barrier discharge ionization-mass spectrometry
A direct and fast method for quantification of illicit drugs in beverages and biological fluids was developed, using dielectric barrier discharge ionization in combination with high-resolution MS.
Cavity-enhanced cantilever-enhanced photo-acoustic spectroscopy
Highly sensitive and selective trace gas detection based on a novel photo-acoustic laser spectroscopy method.
Near-infrared fluorescent aza-BODIPY dyes for sensing and imaging of pH from the neutral to highly alkaline range
New aza-BODIPY pH indicators with spectral properties modulated solely by photoinduced electron transfer (PET) are presented.
SERS-based cascade amplification bioassay protocol of miRNA-21 by using sandwich structure with biotin–streptavidin system
An ultrasensitive SERS-based cascade amplification bioassay is proposed that couples SERS technology with cascade amplification of the B–S system.
Rapid and simple detection of ascorbic acid and alkaline phosphatase via controlled generation of silver nanoparticles and selective recognition
A simple and novel strategy for detection of AA and ALP via controlled generation of Ag NPs and selective recognition.
Quantitative profile–profile relationship (QPPR) modelling: a novel machine learning approach to predict and associate chemical characteristics of unspent ammunition from gunshot residue (GSR)
Possibility to associate gunshot residues with other residues or their original ammunition has been demonstrated using a novel predictive approach.
In-line whole blood fractionation for Raman analysis of blood plasma
Raman studies of dynamically expanded cell-free plasma domains in microfluidic blood flow.
Pattern recognition of toxic metal ions using a single-probe thiocoumarin array
A thiocoumarin that exhibits varying fluorescence responses to metal ions in different solvents can be used in a single-probe multiple-solvent array for distinguishing metal ions.
Merging metabolomics and lipidomics into one analytical run
Dual HILIC and RP chromatography coupled to high-resolution mass spectrometry for the simultaneous analysis of metabolites and lipids.
Poly(amidoamine)-coated magnetic particles for enhanced detection of Schistosoma circulating anodic antigen in endemic urine samples
Charge-based biomarker concentration using magnetic beads improves ultrasensitive schistosomiasis diagnostic and eliminates need for well-equipped laboratory in low-resource settings.
Matrix-assisted laser desorption/ionization tandem mass spectrometry for identification of organic tattoo pigments in inks and tissue samples
Highly specific identification of water-insoluble organic pigments is facilitated by automated matrix-assisted laser desorption/ionization tandem mass spectrometry and data evaluation.
Towards microbioprocess control: an inexpensive 3D printed microbioreactor with integrated online real-time glucose monitoring
A 3D printed micro-bioreactor and microfluidic chip with integrated screen printed glucose biosensor for online monitoring of glucose to aid micro-bioprocess control.
A novel, fast and sensitive supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS) method for analysis of arachidonic acid metabolites
A validated method for rapid and reliable measurement of five arachidonic acid metabolites in biofluids using supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS).
An interdigitated electrode with dense carbon nanotube forests on conductive supports for electrochemical biosensors
A highly sensitive interdigitated electrode (IDE) with vertically aligned dense carbon nanotube forests directly grown on conductive supports was demonstrated by combining UV lithography and a low temperature chemical vapor deposition process (470 °C).
SABRE hyperpolarization enables high-sensitivity 1H and 13C benchtop NMR spectroscopy
Benchtop NMR spectrometers operating with magnetic fields of 1–2 T at sub-ppm resolution coupled with SABRE hyperpolarization show great promise as analytical platforms that can be used outside the traditional laboratory environment.
A facile electrochemical intercalation and microwave assisted exfoliation methodology applied to screen-printed electrochemical-based sensing platforms to impart improved electroanalytical outputs
An Electrochemical Derived Intercalation process is explored as a modification for screen-printed electrodes to improve their electroanalytical outputs.
Polydisperse emulsion digital assay to enhance time to detection and extend dynamic range in bacterial cultures enabled by a statistical framework
We have developed a simple method for preparing small-volume droplets for performing digital culture, allowing for the detection of bacteria.
Salient space detection algorithm for signal extraction from contaminated and distorted spectrum
The proposed algorithm minimizes the influence of baseline distortion and exhibits good anti-noise ability and high real-time performance.
Multimodal imaging of undecalcified tissue sections by MALDI MS and μXRF
Lipid and elemental distributions in chicken phalanx imaged by MALDI MSI and μXRF.
Simultaneous non-polar and polar lipid analysis by on-line combination of HILIC, RP and high resolution MS
Polar and non-polar lipids analysis in 15 min chromatographic run time was enabled by a novel instrumental setup using orthogonal HILIC and RP separation and effluent combination prior to high-resolution mass spectrometry.
Collection of amino acids and DNA from fingerprints using hydrogels
We detail the use of cross-linkable solutions of dextran-methacrylate to form hydrogels capable of collecting amino acids and DNA from fingerprints, while allowing for their increased visualisation at a later stage.
Fast selective trapping and release of picoliter droplets in a 3D microfluidic PDMS multi-trap system with bubbles
A surface acoustic wave (SAW) induces a bubble in a 3D designed multi-trap polydimethylsiloxane (PDMS) device for the selection, incubation and on-demand release of aqueous droplets from a continuous oil flow.
High temporal resolution delayed analysis of clinical microdialysate streams
This paper presents the use of tubing to store clinical microdialysis samples for delayed analysis with high temporal resolution, offering an alternative to traditional discrete offline microdialysis sampling. A model allowing optimal results is described.
Kinetically-enhanced DNA detection via multiple-pass exonuclease III-aided target recycling
A multiple-pass, exonuclease III-mediated target recycling circuit is described for sensitive DNA detection with a shorter assay time.
Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugate
Imaging of the in situ production of nitric oxide following phagocytosis of Escherichia coli bacteria using a NO nanobiosensor.
Cellulose ionics: switching ionic diode responses by surface charge in reconstituted cellulose films
Cellulose films as well as chitosan-modified cellulose films of approximately 5 μm thickness, reconstituted from ionic liquid media onto a poly(ethylene-terephthalate) (PET, 6 μm thickness) film with a 5, 10, 20, or 40 μm diameter laser-drilled microhole, show significant current rectification in aqueous NaCl.
About this collection
This collection features recent open access articles published in Analyst.