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Issue 8, 2019

Fast screening of illicit drugs in beverages and biological fluids by direct coupling of thin film microextraction to dielectric barrier discharge ionization-mass spectrometry

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Abstract

A direct and fast method for screening and quantification of illicit drugs in beverages and biological fluids was developed by using dielectric barrier discharge (DBD) as ionization technique, in combination with high-resolution mass spectrometry. Extraction of the targeted analytes was carried out with thin film microextraction (TFME) using ultrasound as agitation method. The targeted analytes were then thermally desorbed and introduced into the source without the need for any cryofocusing apparatus. The performance of this new analytical set up were compared to conventional TFME-TDU-GC/MS, showing enhanced linear dynamic range and lower limits of quantitation (low pg ml−1) achievable at the same extraction conditions (5 min extraction time). The performance of the method was tested in different beverages and body fluids, confirming its applicability for quantitative analysis of the targeted drugs in complex samples.

Graphical abstract: Fast screening of illicit drugs in beverages and biological fluids by direct coupling of thin film microextraction to dielectric barrier discharge ionization-mass spectrometry

Article information


Submitted
17 Dec 2018
Accepted
05 Mar 2019
First published
08 Mar 2019

This article is Open Access

Analyst, 2019,144, 2788-2796
Article type
Paper

Fast screening of illicit drugs in beverages and biological fluids by direct coupling of thin film microextraction to dielectric barrier discharge ionization-mass spectrometry

M. F. Mirabelli, E. Gionfriddo, J. Pawliszyn and R. Zenobi, Analyst, 2019, 144, 2788 DOI: 10.1039/C8AN02448K

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