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Issue 3, 2018

High temporal resolution delayed analysis of clinical microdialysate streams

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Abstract

This paper presents the use of tubing to store clinical microdialysis samples for delayed analysis with high temporal resolution, offering an alternative to traditional discrete offline microdialysis sampling. Samples stored in this way were found to be stable for up to 72 days at −80 °C. Examples of how this methodology can be applied to glucose and lactate measurement in a wide range of in vivo monitoring experiments are presented. This paper presents a general model, which allows for an informed choice of tubing parameters for a given storage time and flow rate avoiding high back pressure, which would otherwise cause the microdialysis probe to leak, while maximising temporal resolution.

Graphical abstract: High temporal resolution delayed analysis of clinical microdialysate streams

Supplementary files

Article information


Submitted
20 Jul 2017
Accepted
19 Oct 2017
First published
16 Jan 2018

This article is Open Access

Analyst, 2018,143, 715-724
Article type
Paper

High temporal resolution delayed analysis of clinical microdialysate streams

S. A. N. Gowers, K. Hamaoui, P. Cunnea, S. Anastasova, V. F. Curto, P. Vadgama, G.-Z. Yang, V. Papalois, E. M. Drakakis, C. Fotopoulou, S. G. Weber and M. G. Boutelle, Analyst, 2018, 143, 715 DOI: 10.1039/C7AN01209H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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