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Issue 2, 2016

Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

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Abstract

Extracellular vesicles (EVs) are cell-derived nanovesicles, present in almost all types of body fluids, which play an important role in intercellular communication and are involved in the transport of biological signals for regulating diverse cellular functions. Due to the increasing clinical interest in the role of EVs in tumor promotion, various techniques for their isolation, detection, and characterization are being developed. In this review, we present an overview of the current EV isolation and characterization methods in addition to their applications and limitations. Furthermore, EVs as the potential emerging biomarkers in cancer management and their clinical implementation are briefly discussed.

Graphical abstract: Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

Article information


Submitted
29 Aug 2015
Accepted
25 Oct 2015
First published
26 Oct 2015

This article is Open Access

Analyst, 2016,141, 371-381
Article type
Minireview

Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

V. Sunkara, H. Woo and Y. Cho, Analyst, 2016, 141, 371 DOI: 10.1039/C5AN01775K

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