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Issue 9, 2018

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

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Abstract

Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures.

Graphical abstract: Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

Supplementary files

Article information


Submitted
09 Feb 2018
Accepted
29 Mar 2018
First published
09 Apr 2018

This article is Open Access

Analyst, 2018,143, 1997-2001
Article type
Communication

Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol and U. Karst, Analyst, 2018, 143, 1997 DOI: 10.1039/C8AN00258D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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