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Issue 3, 2019

Advances in mass spectrometry based single-cell metabolomics

Author affiliations

Abstract

Metabolomics has grown into a prominent field contributing to the molecular understanding of complex biological processes in both health and disease. Furthermore, single-cells are known to display metabolic differences between seemingly homogeneous populations of cells. Single-cell metabolomics attempts to analyze many cellular metabolites from single cells to understand phenotypic heterogeneity, which is a significant challenge due to the low analyte abundances and limited sample volumes. Label-free metabolite detection can be achieved with mass spectrometry, which is capable of simultaneously analyzing hundreds of metabolites. Herein, we review the recent advances in mass spectrometry based single-cell metabolomics, highlighting the current state-of-the-art within the last three years, and identify the challenges to move the field forward.

Graphical abstract: Advances in mass spectrometry based single-cell metabolomics

Article information


Submitted
15 Aug 2018
Accepted
12 Oct 2018
First published
23 Oct 2018

This article is Open Access

Analyst, 2019,144, 782-793
Article type
Minireview

Advances in mass spectrometry based single-cell metabolomics

K. D. Duncan, J. Fyrestam and I. Lanekoff, Analyst, 2019, 144, 782 DOI: 10.1039/C8AN01581C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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