Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Vincenzo Naddeo and Haizhou Liu present an ‘Editorial Perspective’ on coronavirus in wastewater and discuss the water research needs to combat viral outbreaks.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Ultraviolet germicidal irradiation is one method for decontamination of N-95 filtering facepiece respirators to facilitate reuse during the COVID-19 pandemic. Other techniques include hydrogen peroxide vaporization, microwave-generated steaming, and dry heating.
Trends and targets in antiviral phototherapy
With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Multiplex lateral flow immunoassays for outstanding POCT of infectious diseases.
Novel biosensing methodologies for ultrasensitive detection of viruses
Biosensors function as rapid, sensitive and specific diagnostic tools for various viral infectious diseases.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Recent developments in the biological activities of polyoxometalates (metal-oxide cluster anions) are discussed from the chemotherapeutic point of view for a novel inorganic drug.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Potential drug candidates derived from natural sources are posed for the development of anti-SARS CoV-2 therapeutics.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Herpes Simplex Virus type 1 (HSV-1) is a nuclear replicating enveloped virus.
Antiviral drug discovery: broad-spectrum drugs from nature
Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.
Influenza neuraminidase: A druggable target for natural products
This review covers the increasing research efforts of the past decade, focusing on the structure, function and druggability of influenza NA, and its inhibition by natural products. Latest developments in theoretical and experimental research on NA for lead discovery strategies from nature are presented.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
This review provides a comprehensive look at whether a pandemic enveloped virus would pose challenges for the wastewater and drinking water industries.
The role of biosensors in the detection of emerging infectious diseases
An ideal approach to real-time disease detection and surveillance.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Multicolor silver nanoparticles enable multiplexed detection of dengue, yellow fever, and Ebola virus proteins in a single lateral flow strip.
Inhibition of SARS coronavirus helicase by bismuth complexes
The SARS-CoV NTPase/helicase being able to unwind both RNA and DNA duplexes, is an attractive target for anti-viral drug design. A series of bismuth complexes were synthesized and characterized, and exhibit the inhibition against the SARS helicase ATPase and duplex-unwinding activities at micromolar concentrations.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
SARS-CoV-2 3CLpro shows homology in binding to an aza-peptide epoxide (APE) known for the irreversible inhibition of main peptidase in SARS-CoV.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
Anti-HIV drug repurposing against SARS-CoV-2
A novel severe acute respiratory syndrome human coronavirus (SARS HCoV) was identified from respiratory illness patients (named SARS-CoV-2 by ICTV) in December 2019 and has recently emerged as a serious threat to world public health.
Length-scale dependence of protein hydration-shell density
An increase in protein hydration-shell density relative to that of the bulk is observed (in the range of 4–14%) for all studied proteins and this density-increment, which decreases for decreasing protein size, is caused by the protein size only.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Mercaptoethane sulfonate functionalised Te/BSA nanostars are prepared and exhibit excellent antiviral activity against arteriviruses and coronaviruses.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The polymerase chain reaction (PCR) has unique advantages of sensitivity, specificity and rapidity in pathogen detection, which makes it at the forefront of academia and application in molecular biology diagnosis.
An electrophoretic DNA extraction device using a nanofilter for molecular diagnosis of pathogens
A simple electrophoretic DNA extraction device has developed using a nanofilter for rapid and efficient DNA aquisition required for point-of-care analysis in order to prevent an epidemic/pandemic disease outbreak.
A structure-free digital microfluidic platform for detection of influenza a virus by using magnetic beads and electromagnetic forces
A new type of digital microfluidic platform for influenza A H1N1 virus detection by utilizing a one-aptamer/two-antibodies assay on magnetic beads was reported.
A sample-to-answer, portable platform for rapid detection of pathogens with a smartphone interface
A smartphone-controlled, automated, and portable system was developed for rapid molecular diagnosis of pathogens via the use of a colorimetric loop-mediated isothermal amplification (LAMP) approach on a passive, self-driven microfluidic device.
Semi-automatic instrumentation for nucleic acid extraction and purification to quantify pathogens on surfaces
A semi-automated detection system compatible with PCR that can detect infectious pathogens on wide surfaces in a short time.
A chip-based potentiometric sensor for a Zika virus diagnostic using 3D surface molecular imprinting
The high sensitivity and high selectivity demonstrated here proved that this lab-on-a-chip diagnostic has the potential to become a point-of-care (POC) detection system for rapid and accurate screening of flaviviruses.
Rapid immunodiagnostics of multiple viral infections in an acoustic microstreaming device with serum and saliva samples
There is a need to screen multiple infections simultaneously rather than one infection at a time to improve the quality of healthcare.
Integration of a 3D-printed read-out platform with a quantum dot-based immunoassay for detection of the avian influenza A (H7N9) virus
Outbreaks and potential epidemics of the highly pathogenic avian influenza virus pose serious threats to human health and the global economy.
Visual detection of Zika virus by isothermal nucleic acid amplification combined with a lateral-flow device
The Zika virus (ZIKV) did not receive significant attention in the past until the ZIKV outbreak occurred a few years ago.
An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR
A microfluidic chip featuring HA × NA arrayed reaction chambers for RT-PCR was developed for diagnosis and subtyping of influenza A viruses.
An integrated device for the rapid and sensitive detection of the influenza hemagglutinin
We demonstrate the swab-to-result detection of influenza virus using a novel paper microfluidic device. This device incorporates computationally designed affinity proteins with enzymatic amplification for improved sensitivity and specificity.
Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method
We developed a real-time colorimetric method based on LAMP-integrated microfluidic chip system for diagnosing multiple respiratory viruses.
Synthesis and antiviral activity of novel spirocyclic nucleosides
A diverse range of spirocyclic nucleosides have been prepared from a common precursor and tested for their antiviral activity.
A hand-held device for rapid single tube detection of hepatitis-C virus
A Single Tube Analysis system using LAMP, LED and ION-sensing (STALLION) for pathogen derived RNA/DNA.
High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice
Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting in hospitalization.
Sensitive and rapid detection of pathogenic bacteria from urine samples using multiplex recombinase polymerase amplification
Multiple detection of pathogenic bacteria from urine samples was achieved on a centrifugal microfluidic chip using RPA.
Nanoparticle-enhanced electrical detection of Zika virus on paper microchips
Zika virus (ZIKV) is a reemerging flavivirus causing an ongoing pandemic and public health emergency worldwide. We developed nanoparticle-enhanced sensing of virus lysate for electrical detection of ZIKV on paper microchip.
A fully-integrated and automated testing device for PCR-free viral nucleic acid detection in whole blood
Integrated devices for automated nucleic acid testing (NAT) are critical for infectious disease diagnosis to be performed outside of centralized laboratories.
Rapid and sensitive detection of viral nucleic acids using silicon microchips
Rapid and sensitive amplification of viral nucleic acids is feasible on a flexible silicon microchip technology platform.
Understanding the viral load during the synthesis and after rebinding of virus imprinted particles via real-time quantitative PCR
In the present study, virus imprinted particles have been synthesized for recognizing and specifically binding viruses.
Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity
Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.
Dengue serotyping with a label-free DNA sensor
Detection of dengue target by generation of silver nanoclusters using cocktail probes and single probe assay.
Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection
A β-cyclodextrin functionalized graphene oxide and curcumin composite was developed with excellent antiviral activity against the respiratory syncytial virus.
Self-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses
Nanoengineered chiral gold nanoparticles and quantum dots for ultrasensitive chiroptical sensing of viruses in blood samples.
vhfRNAi: a web-platform for analysis of host genes involved in viral infections discovered by genome wide RNAi screens
Knockdown of host genes using high-throughput genome-wide RNA interference screens has identified numerous host factors that affect viral infections, which would be helpful in understanding host–virus interactions.
Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses
A capillary-flow based automated microfluidic system for multiplexed visualization of single viruses in serum.
A paper-based platform for detection of viral RNA
Viral detection presents a host of challenges for even the most sensitive analytical techniques, and the complexity of common detection platforms typically preclude portability.
Paper microchip with a graphene-modified silver nano-composite electrode for electrical sensing of microbial pathogens
Paper-based point-of-care microchips can shift the paradigm in the management of infectious diseases.
Development of a point-of-care diagnostic for influenza detection with antiviral treatment effectiveness indication
A novel, point-of-care style influenza μPAD with the ability to determine strain antiviral susceptibility for enhanced treatment decision.
Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker
A novel DNA sensor system for detection of retrovirus encoded integrase (IN) is presented.
Rapid detection of Hendra virus antibodies: an integrated device with nanoparticle assay and chaotic micromixing
An integrated device with nanoparticle assay and chaotic micromixing for rapid detection of Hendra virus antibodies.
Simultaneous detection of multiple viruses based on chemiluminescence and magnetic separation
In this report, a DNA hybridization based chemiluminescent detection method has been proposed for reliable detection of multiple pathogens. The use of surface modified magnetic nanoparticles can help to integrate this system into an automated platform for high throughput applications.
Novel magnetic relaxation nanosensors: an unparalleled “spin” on influenza diagnosis
Development of new functional magnetic resonance nanosensors for the rapid detection of influenza subtypes through surface conjugation with sialic acid ligands and entry blocker peptides.
Ultrafast, sensitive and large-volume on-chip real-time PCR for the molecular diagnosis of bacterial and viral infections
We present an ultra-fast microfluidic real-time PCR system enabling analysis in ≈7 minutes while conserving large volume and high efficiency/sensitivity.
A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples
We present a low-cost, disposable, and fully-integrated paperfluidic molecular diagnostic chip for sample-to-result functionality at the point-of-care.
High sensitive and direct fluorescence detection of single viral DNA sequences by integration of double strand probes onto microgels particles
A novel class of probes for fluorescence detection was developed and combined to microgel particles for a high sensitive fluorescence detection of nucleic acids.
Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection
Uniform and stable curcumin-AgNPs, which are synthesized with a simple method, show excellent antiviral properties against respiratory syncytial virus.
Engineered nanoconstructs for the multiplexed and sensitive detection of high-risk pathogens
A novel sandwich immunoassay for the high sensitive detection of inactivated high-risk pathogens with engineered apoferritin nanoprobes.
LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
Sample supply remains the only manual handling step for pathogen detection at the point-of-care.
Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein
Nucleocapsid protein (NP), an essential RNA-binding viral protein in human coronavirus (CoV)-infected cells, is an antiviral target for drug discovery.
Safflomin A inhibits neuraminidase activity and influenza virus replication
Neuraminidase (NA) is a glycoprotein on the surface of the influenza virus that plays an important role in the early processes of virus infection and viral release from the infected cells.
Rapid, targeted and culture-free viral infectivity assay in drop-based microfluidics
We developed a rapid, targeted and culture-free infectivity assay using high-throughput drop-based microfluidics. The high sensitivity and large dynamic range of our cost effective assay alleviates the need for serial dilution experiments.
Multiplexed detection of viral infections using rapid in situ RNA analysis on a chip
This paper presents an automated platform for ultra rapid detection of respiratory viruses using RNA FISH.
Potential antiviral activities of camel, bovine, and human lactoperoxidases against hepatitis C virus genotype 4
Lactoperoxidases (LPOs) were assayed against hepatitis C virus (HCV) using PCR. Direct interaction of HCV with LPO neutralized the viral particles and prevented entry into cells. LPOs inhibited virus amplification in infected HepG2 cells with a relative activity of 100%.
A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection
A new non-PCR assay platform using RNase H to detect MicroRNA 29a-3p from patients’ throat swabs with influenza A virus H1N1 infection.
Automated nucleic acid extraction from whole blood, B. subtilis, E. coli, and Rift Valley fever virus on a centrifugal microfluidic LabDisk
We present total nucleic acid extraction from whole blood, Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and Rift Valley fever RNA virus on a low-cost, centrifugal microfluidic cartridge processed in a portable processing device.
Continuous aerosol size separator using inertial microfluidics and its application to airborne bacteria and viruses
A novel microchannel-based inertial separator that can rapidly and continuously separate submicron aerosols according to particle inertial differences and Dean vortices in the airflow was developed.
Integration of reverse transcriptase loop-mediated isothermal amplification with an immunochromatographic strip on a centrifugal microdevice for influenza A virus identification
In this paper, we demonstrated an integrated centrifugal microdevice which could perform reverse transcriptase loop-mediated isothermal amplification and immunochromatographic strip based amplicon analysis for rapid, sensitive, and multiplex influenza A virus detection.
About this collection
All Royal Society of Chemistry articles on coronavirus research can be found here and are freely available.