Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Brian Pecson and Daniel Gerrity present an Editorial Perspective which focuses on the impact of SARS-CoV-2 on the water industry.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Vincenzo Naddeo and Haizhou Liu present an ‘Editorial Perspective’ on coronavirus in wastewater and discuss the water research needs to combat viral outbreaks.
Nano- and biosensors for the detection of SARS-CoV-2: challenges and opportunities
Recent advances in the design of nano- and biosensors, as well as important challenges and opportunities related to the detection of SARS-CoV-2 and COVID-19 diagnosis, are discussed.
Envisioned strategy for an early intervention in virus-suspected patients through non-invasive piezo- and pyro-electric-based wearable sensors
This perspective explores the scope of piezo- and pyro-electric wearable sensors towards the early intervention of virus-affected patients, particularly in the context of the ongoing COVID-19 pandemic.
Soft matter science and the COVID-19 pandemic
Much of the science underpinning the global response to the COVID-19 pandemic lies in the soft matter domain.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
The appearance of new and lethal viruses and their potential threat urgently requires innovative antiviral systems.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Ultraviolet germicidal irradiation is one method for decontamination of N-95 filtering facepiece respirators to facilitate reuse during the COVID-19 pandemic. Other techniques include hydrogen peroxide vaporization, microwave-generated steaming, and dry heating.
Trends and targets in antiviral phototherapy
With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.
Growth of Legionella during COVID-19 lockdown stagnation
While “avoiding stagnation” has been the mantra of building water experts, support for how this terminology is used is not overly convincing. Carefully nuanced COVID stagnation studies can improve water quality research and communication strategies.
The role of biomaterials and three dimensional (3D) in vitro tissue models in fighting against COVID-19
Biomaterials in company with bioengineered tissue models enables scientists to develop the more precise disease models and find better solutions in infectious respiratory disease treatment.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Multiplex lateral flow immunoassays for outstanding POCT of infectious diseases.
Novel biosensing methodologies for ultrasensitive detection of viruses
Biosensors function as rapid, sensitive and specific diagnostic tools for various viral infectious diseases.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Recent developments in the biological activities of polyoxometalates (metal-oxide cluster anions) are discussed from the chemotherapeutic point of view for a novel inorganic drug.
The chemical biology of coronavirus host–cell interactions
Chemical biology strategies can play important roles in studying the complexity of SARS-CoV-2–host interactions at molecular level detail.
SARS-CoV-2 and Tissue Damage: Current Insights and Biomaterial-based Therapeutic Strategies
Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides
Fighting COVID-19 with high affinity reagents: this review article summarizes the discovery of several classes of (bio) molecules targeting the SARS-CoV-2 spike protein.
ACE2 as a potential therapeutic target for pandemic COVID-19
SARS-CoV-2 virus invades the host through angiotensin-converting enzyme 2 (ACE2) receptors by decreasing the ACE2 expression of the host.
Diagnostic technologies for COVID-19: a review
Summary of the latest research progress on detection methods of SARS-CoV-2, providing a reference to develop rapid and accurate diagnostic strategies for COVID-19.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Since the coronaviruses that cause COVID-19 and SARS-CoV-1 share 80% structural similarity, we present a comprehensive review of the diverse molecular inhibitors of SARS-CoV-1. This will help to accelerate drug discovery for deadly coronavirus diseases.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
A schematic representation of different methods to inhibit SARS-CoV-2 infection.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Potential drug candidates derived from natural sources are posed for the development of anti-SARS CoV-2 therapeutics.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Herpes Simplex Virus type 1 (HSV-1) is a nuclear replicating enveloped virus.
Antiviral drug discovery: broad-spectrum drugs from nature
Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.
Influenza neuraminidase: A druggable target for natural products
This review covers the increasing research efforts of the past decade, focusing on the structure, function and druggability of influenza NA, and its inhibition by natural products. Latest developments in theoretical and experimental research on NA for lead discovery strategies from nature are presented.
Point-of-Care Testing Detection Methods for COVID-19
A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic
Active pharmaceutical ingredients (APIs) are increasingly being identified as contaminants of emerging concern (CECs).
Current advances in the detection of COVID-19 and evaluation of the humoral response
SARS-CoV-2 and humoral response determinations to understand and control the spread of COVID-19.
Detection of RNA viruses from influenza and HIV to Ebola and SARS-CoV-2: a review
RNA-based viruses likely make up the highest pandemic threat among all known pathogens in about the last 100 years, since the Spanish Flu of 1918 with 50 M deaths up to COVID-19.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
This review provides a comprehensive look at whether a pandemic enveloped virus would pose challenges for the wastewater and drinking water industries.
The role of biosensors in the detection of emerging infectious diseases
An ideal approach to real-time disease detection and surveillance.
Colorimetric loop-mediated isothermal amplification (LAMP) for cost-effective and quantitative detection of SARS-CoV-2: the change in color in LAMP-based assays quantitatively correlates with viral copy number
Colorimetric LAMP for COVID-19 intensified diagnostics: a simple and quantitative method comparable in diagnostic performance to RT-qPCR.
High-throughput wastewater analysis for substance use assessment in central New York during the COVID-19 pandemic
Wastewater analysis provides insights into population lifestyle and health status during the coronavirus pandemic.
Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection
Development of an identification methodology with PS-MS as a sensitive and rapid technique to obtain vastly different chemical changes in COVID-19 infection.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Unveiling the nanomechanical stability of the novel coronavirus (SARS-CoV-2) spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Using a combination of enhanced sampling molecular dynamics techniques and non-equilibrium alchemical transformations, we have shown that hydroxychloroquine may act as a mild inhibitor of important functional proteins for SARS-CoV2 replication.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Multicolor silver nanoparticles enable multiplexed detection of dengue, yellow fever, and Ebola virus proteins in a single lateral flow strip.
Inhibition of SARS coronavirus helicase by bismuth complexes
The SARS-CoV NTPase/helicase being able to unwind both RNA and DNA duplexes, is an attractive target for anti-viral drug design. A series of bismuth complexes were synthesized and characterized, and exhibit the inhibition against the SARS helicase ATPase and duplex-unwinding activities at micromolar concentrations.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
A versatile aptamer-assisted proximity ligation system improves diagnosis of COVID-19, and allows the evaluation of potential neutralizing aptamers.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
By integrating algebraic topology and deep learning, we provide a reliable ranking of binding affinities, binding site analysis, and fragment decomposition for 137 SARS-CoV-2 main protease inhibitors.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
A computer program for retrosynthetic planning helps develop multiple “synthetic contingency” plans for hydroxychloroquine and also routes leading to remdesivir, both promising but yet unproven medications against COVID-19.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Herein we present a workflow for design and synthesis of novel selective Ub-based tools for DUBs. Selectivity is achieved by incorporation of unnatural amino acids into the Ub C-terminal epitope.
The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the coronavirus disease that began in 2019 (COVID-19), has been responsible for 1.4 million deaths worldwide as of 13 November 2020.
Carbon nanotubes for rapid capturing of SARS-COV-2 virus: revealing a mechanistic aspect of binding based on computational studies
Investigation of the binding interactions of synthesized multi-walled carbon nanotubes (MWCNTs) with SARS-CoV-2 virus.
Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19
The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e. 14-deoxy-11,12-didehydroandrographolide with targets related to COVID-19 and their probable role in regulating multiple pathways in COVID-19 infection.
A digital protein microarray for COVID-19 cytokine storm monitoring
A digital microfluidic immunoassay platform enables rapid multiplex quantification of proinflammatory cytokines in serum for critically ill COVID-19 patients.
Colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a visual diagnostic platform for the detection of the emerging coronavirus SARS-CoV-2
RT-LAMP to detect SARS-CoV-2: in a positive sample, RT-LAMP leads to a color change from pink to yellow.
Ligand-based design, molecular dynamics and ADMET studies of suggested SARS-CoV-2 Mpro inhibitors
Compounds I–X were designed to inhibit SARS-CoV-2 Mpro based on pharmacophore modeling of SARS-CoV Mpro inhibitors. Compounds V and VI showed promising molecular docking and molecular dynamic simulation results that surpassed baicalein.
In silico design of peptides with binding to the receptor binding domain (RBD) of the SARS-CoV-2 and their utility in bio-sensor development for SARS-CoV-2 detection
The protocol for peptide design and testing for its usage as a sensor.
Interaction analyses of SARS-CoV-2 spike protein based on fragment molecular orbital calculations
Visualized IFIE results seen from chain-B of spike protein.
Binding of inhibitors to the monomeric and dimeric SARS-CoV-2 Mpro
Binding of inhibitors to the monomeric SARS-CoV-2 Mpro is similar to the dimeric one.
Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid–base equilibria
Identification of potential inhibitory effect of acid–base species of quercetin and its metabolite as well as chloroquine, hydroxychloroquine, and cinanserin, at physiological pH, on proteins essential for SARS-CoV-2 virus survival.
A high-throughput multiplexed microfluidic device for COVID-19 serology assays
A microfluidic device to quantitate antibody reactivities to SARS-CoV-2 antigens: spike protein, RDB, S1 subunit, and nucleocapsid, from 50 serum samples.
Interpretation of SARS-CoV-2 behaviour on different substrates and denaturation of virions using ethanol: an atomic force microscopy study
We studied the density and aggregation behavior of virions on TCPS and glass substrates, surface functionality, coffee ring effect on both surfaces and the effect of ethanol-based disinfectant on the virion structure using atomic force microscopy.
In silico identification of SARS-CoV-2 spike (S) protein–ACE2 complex inhibitors from eight Tecoma species and cultivars analyzed by LC-MS
In silico exploration of 12 Tecoma phytocompounds that could serve as potential inhibitors of SARS-CoV entry to host cells.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The polymer polyphosphate, abundant in blood platelets, blocks the binding of the receptor-binding domain (RBD) of the SARS- spike (S)-protein to the angiotensin-converting enzyme 2 (ACE2) at low concentrations.
Detection of the SARS-CoV-2 humanized antibody with paper-based ELISA
This work reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection of the severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) humanized antibody.
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
New computational protocol applied to a repurposing campaign against SARS-CoV-2.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
COVID-19 is a widespread and highly contagious disease in the human population.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Free Energy Pertubation (FEP) can be used to accurately predict the binding affinity of a ligand to the main protease (Mpro) of the novel coronavirus SARS-CoV-2.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Exploring effective disinfection methods and understanding their mechanisms on the new coronavirus is becoming more active due to the outbreak of novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory coronavirus 2 (SARS-CoV-2).
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Structure-based design of SARS-CoV-2 main protease inhibitors identified hydantoin, benzothiazine and cresol moieties as promising residues of new peptidomimetic inhibitors.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Novel coronavirus (CoV) is the primary etiological virus responsible for the pandemic that started in Wuhan in 2019–2020.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Gly504 interacting with two nearest neighbor and one non-local amino acids.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Tri(4′-diphenylphosphonyloxylbenzoyl phenyl)phosphate (TDPBP) derivatives were developed as greener supports to aid high-efficiency liquid-phase peptide synthesis without the need for unrecyclable resin and tedious chromatographic separation.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
On Wednesday 11th March, 2020, the world health organization (WHO) announced novel coronavirus (COVID-19, also called SARS-CoV-2) as a pandemic.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Inhibitory potential of ilimaquinone (marine sponge metabolite) against nine essential SARS-CoV-2 target proteins, employing a molecular interaction and dynamics simulation approach.
About this collection
All Royal Society of Chemistry articles on coronavirus research can be found here and are freely available until 31st December 2021.