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Themed collection Coronavirus articles - free to access collection

29 items
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Vincenzo Naddeo and Haizhou Liu present an ‘Editorial Perspective’ on coronavirus in wastewater and discuss the water research needs to combat viral outbreaks.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Perspective

Trends and targets in antiviral phototherapy

With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Biosensors function as rapid, sensitive and specific diagnostic tools for various viral infectious diseases.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Recent developments in the biological activities of polyoxometalates (metal-oxide cluster anions) are discussed from the chemotherapeutic point of view for a novel inorganic drug.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

This review provides a comprehensive look at whether a pandemic enveloped virus would pose challenges for the wastewater and drinking water industries.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

An ideal approach to real-time disease detection and surveillance.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

The SARS-CoV NTPase/helicase being able to unwind both RNA and DNA duplexes, is an attractive target for anti-viral drug design. A series of bismuth complexes were synthesized and characterized, and exhibit the inhibition against the SARS helicase ATPase and duplex-unwinding activities at micromolar concentrations.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Paper

Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method

We developed a real-time colorimetric method based on LAMP-integrated microfluidic chip system for diagnosing multiple respiratory viruses.

Graphical abstract: Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method
Paper

Synthesis and antiviral activity of novel spirocyclic nucleosides

A diverse range of spirocyclic nucleosides have been prepared from a common precursor and tested for their antiviral activity.

Graphical abstract: Synthesis and antiviral activity of novel spirocyclic nucleosides
Open Access Paper

High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice

Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting in hospitalization.

Graphical abstract: High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice
Paper

Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity

Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.

Graphical abstract: Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity
Open Access Paper

Self-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses

Nanoengineered chiral gold nanoparticles and quantum dots for ultrasensitive chiroptical sensing of viruses in blood samples.

Graphical abstract: Self-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses
Paper

High sensitive and direct fluorescence detection of single viral DNA sequences by integration of double strand probes onto microgels particles

A novel class of probes for fluorescence detection was developed and combined to microgel particles for a high sensitive fluorescence detection of nucleic acids.

Graphical abstract: High sensitive and direct fluorescence detection of single viral DNA sequences by integration of double strand probes onto microgels particles
Paper

Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection

Uniform and stable curcumin-AgNPs, which are synthesized with a simple method, show excellent antiviral properties against respiratory syncytial virus.

Graphical abstract: Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection
Open Access Paper

LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus

Sample supply remains the only manual handling step for pathogen detection at the point-of-care.

Graphical abstract: LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
Paper

Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein

Nucleocapsid protein (NP), an essential RNA-binding viral protein in human coronavirus (CoV)-infected cells, is an antiviral target for drug discovery.

Graphical abstract: Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein
Paper

Continuous aerosol size separator using inertial microfluidics and its application to airborne bacteria and viruses

A novel microchannel-based inertial separator that can rapidly and continuously separate submicron aerosols according to particle inertial differences and Dean vortices in the airflow was developed.

Graphical abstract: Continuous aerosol size separator using inertial microfluidics and its application to airborne bacteria and viruses
Paper

Approaches to design non-covalent inhibitors for human granzyme B (hGrB)

A structure-based design campaign for non-covalent small molecule inhibitors of hGrB was carried out by virtual screening employing three constraints and probe site-mapping with FTMAP to identify ligand “hot spots”.

Graphical abstract: Approaches to design non-covalent inhibitors for human granzyme B (hGrB)
Paper

Rapid identification of H5 avian influenza virus in chicken throat swab specimens using microfluidic real-time RT-PCR

Microfluidic PCR system with an integrated online fluorescence detection module and an embedded computer for real-time data processing.

Graphical abstract: Rapid identification of H5 avian influenza virus in chicken throat swab specimens using microfluidic real-time RT-PCR
Paper

Under-three minute PCR: Probing the limits of fast amplification

SARS was chosen due to its importance as a public health threat and exemplar of the potential benefits of ultra-fast PCR in rapid screening.

Graphical abstract: Under-three minute PCR: Probing the limits of fast amplification
Paper

Rapid detection for primary screening of influenza A virus: microfluidic RT-PCR chip and electrochemical DNA sensor

We demonstrate the use of a continuous-flow polydimethylsiloxane (PDMS) microfluidic RT-PCR chip and disposable electrical printed (DEP) chips for rapid amplification and sensing of new influenza (AH1pdm) virus of swine-origin.

Graphical abstract: Rapid detection for primary screening of influenza A virus: microfluidic RT-PCR chip and electrochemical DNA sensor
Paper

A self-contained all-in-one cartridge for sample preparation and real-time PCR in rapid influenza diagnosis

This work demonstrates a fully automated system with multiplexing capability for the rapid diagnosis of infectious diseases. The system automatically performs DNA/RNA sample preparation, reagent metering, aliquot dispensing, and real-time RT-PCR with self-contained reagents in a disposable polymer cartridge.

Graphical abstract: A self-contained all-in-one cartridge for sample preparation and real-time PCR in rapid influenza diagnosis
Paper

RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein

We describe the high-affinity RNA aptamers capable of capturing SARS coronavirus (SARS-CoV) nucleocapsid (N) protein. A nanoarray aptamer chip with the selected aptamer might have application potential for rapid, sensitive detection of SARS coronavirus.

Graphical abstract: RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein
Paper

An optimized method to detect influenza virus and human rhinovirus from exhaled breath and the airborne environment

Virus detection was improved 10-fold, by using the optimal molecular biology methods to extract nucleic acid (RNA), reverse transcribe RNA and quantify cDNA using quantitative PCR.

Graphical abstract: An optimized method to detect influenza virus and human rhinovirus from exhaled breath and the airborne environment
Paper

Molecular design of inhibitors against the Mproprotein of the severe acute respiratory syndrome (SARS) virus

The main proteinase of SARS coronavirus (3CLpro or Mpro) is crucial for its replication process, and therefore it is a potential target for the development of anti-SARS drugs.

Graphical abstract: Molecular design of inhibitors against the Mproprotein of the severe acute respiratory syndrome (SARS) virus
Paper

Development of a method for bacteria and virus recovery from heating, ventilation, and air conditioning (HVAC) filters

To determine prevalence of natural background pathogens and pathogens’ near neighbors in ambient air, high volume bioaerosol sampling could be conducted using preexisting HVAC filters in building air handling units.

Graphical abstract: Development of a method for bacteria and virus recovery from heating, ventilation, and air conditioning (HVAC) filters
Paper

Screening of specific antigens for SARS clinical diagnosis using a protein microarray

An antigen screening method based on protein microarray is developed and applied to the screening of SARS-CoV antigens. The most specific antigen (N2) screened out is demonstrated by ELISA assay.

Graphical abstract: Screening of specific antigens for SARS clinical diagnosis using a protein microarray
29 items

About this collection

All Royal Society of Chemistry articles on coronavirus research can be found here and are freely available.

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