Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Vincenzo Naddeo and Haizhou Liu present an ‘Editorial Perspective’ on coronavirus in wastewater and discuss the water research needs to combat viral outbreaks.
Trends and targets in antiviral phototherapy
With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.
Novel biosensing methodologies for ultrasensitive detection of viruses
Biosensors function as rapid, sensitive and specific diagnostic tools for various viral infectious diseases.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Recent developments in the biological activities of polyoxometalates (metal-oxide cluster anions) are discussed from the chemotherapeutic point of view for a novel inorganic drug.
Antiviral drug discovery: broad-spectrum drugs from nature
Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
This review provides a comprehensive look at whether a pandemic enveloped virus would pose challenges for the wastewater and drinking water industries.
The role of biosensors in the detection of emerging infectious diseases
An ideal approach to real-time disease detection and surveillance.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.
Inhibition of SARS coronavirus helicase by bismuth complexes
The SARS-CoV NTPase/helicase being able to unwind both RNA and DNA duplexes, is an attractive target for anti-viral drug design. A series of bismuth complexes were synthesized and characterized, and exhibit the inhibition against the SARS helicase ATPase and duplex-unwinding activities at micromolar concentrations.
Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method
We developed a real-time colorimetric method based on LAMP-integrated microfluidic chip system for diagnosing multiple respiratory viruses.
Synthesis and antiviral activity of novel spirocyclic nucleosides
A diverse range of spirocyclic nucleosides have been prepared from a common precursor and tested for their antiviral activity.
High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice
Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting in hospitalization.
Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity
Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.
Self-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses
Nanoengineered chiral gold nanoparticles and quantum dots for ultrasensitive chiroptical sensing of viruses in blood samples.
High sensitive and direct fluorescence detection of single viral DNA sequences by integration of double strand probes onto microgels particles
A novel class of probes for fluorescence detection was developed and combined to microgel particles for a high sensitive fluorescence detection of nucleic acids.
Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection
Uniform and stable curcumin-AgNPs, which are synthesized with a simple method, show excellent antiviral properties against respiratory syncytial virus.
LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
Sample supply remains the only manual handling step for pathogen detection at the point-of-care.
Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein
Nucleocapsid protein (NP), an essential RNA-binding viral protein in human coronavirus (CoV)-infected cells, is an antiviral target for drug discovery.
Continuous aerosol size separator using inertial microfluidics and its application to airborne bacteria and viruses
A novel microchannel-based inertial separator that can rapidly and continuously separate submicron aerosols according to particle inertial differences and Dean vortices in the airflow was developed.
Approaches to design non-covalent inhibitors for human granzyme B (hGrB)
A structure-based design campaign for non-covalent small molecule inhibitors of hGrB was carried out by virtual screening employing three constraints and probe site-mapping with FTMAP to identify ligand “hot spots”.
Rapid identification of H5 avian influenza virus in chicken throat swab specimens using microfluidic real-time RT-PCR
Microfluidic PCR system with an integrated online fluorescence detection module and an embedded computer for real-time data processing.
Under-three minute PCR: Probing the limits of fast amplification
SARS was chosen due to its importance as a public health threat and exemplar of the potential benefits of ultra-fast PCR in rapid screening.
Rapid detection for primary screening of influenza A virus: microfluidic RT-PCR chip and electrochemical DNA sensor
We demonstrate the use of a continuous-flow polydimethylsiloxane (PDMS) microfluidic RT-PCR chip and disposable electrical printed (DEP) chips for rapid amplification and sensing of new influenza (AH1pdm) virus of swine-origin.
A self-contained all-in-one cartridge for
sample preparation and real-time PCR in rapid influenza diagnosis
This work demonstrates a fully automated system with multiplexing capability for the rapid diagnosis of infectious diseases. The system automatically performs DNA/RNA sample preparation, reagent metering, aliquot dispensing, and real-time RT-PCR with self-contained reagents in a disposable polymer cartridge.
RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid
We describe the high-affinity RNA aptamers capable of capturing SARS coronavirus (SARS-CoV) nucleocapsid (N) protein. A nanoarray aptamer chip with the selected aptamer might have application potential for rapid, sensitive detection of SARS coronavirus.
An optimized method to detect influenza virus and human rhinovirus from exhaled breath and the airborne environment
Virus detection was improved 10-fold, by using the optimal molecular biology methods to extract nucleic acid (RNA), reverse transcribe RNA and quantify cDNA using quantitative PCR.
Molecular design of
inhibitors against the Mproprotein of the severe acute respiratory syndrome (SARS) virus
The main proteinase of SARS coronavirus (3CLpro or Mpro) is crucial for its replication process, and therefore it is a potential target for the development of anti-SARS drugs.
Development of a method for bacteria and virus recovery from heating, ventilation, and air conditioning (HVAC) filters
To determine prevalence of natural background pathogens and pathogens’ near neighbors in ambient air, high volume bioaerosol sampling could be conducted using preexisting HVAC filters in building air handling units.
Screening of specific
antigens for SARS clinical diagnosis using a protein microarray
An antigen screening method based on protein microarray is developed and applied to the screening of SARS-CoV antigens. The most specific antigen (N2) screened out is demonstrated by ELISA assay.
About this collection
All Royal Society of Chemistry articles on coronavirus research can be found here and are freely available.