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Themed collection Editors’ collection: Photodynamic therapy

35 items
Open Access Paper

A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

Graphene–gold nanocomposite materials combined with (5-fluorouracil, 5-FU) drug show high potent cytotoxicity against MCF-7 cells, can decrease HER-2 gene expression and cause cell cycle arrest.

Graphical abstract: A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Novel one pot synthesis and spectroscopic characterization of a folate-Mn3O4 nanohybrid for potential photodynamic therapeutic application

Folate capped Mn3O4 nanoparticles can be used in PDT for specifically destroying folate receptor-overexpressing cancer cells through photo induced free radical damage.

Graphical abstract: Novel one pot synthesis and spectroscopic characterization of a folate-Mn3O4 nanohybrid for potential photodynamic therapeutic application
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

Ag2S/BSA hybrid nanoparticles were prepared and studied for their ability to inhibit the growth of human lymphoma cells under light irradiation, via inducing the accumulation of intracellular reactive oxidative species to disrupt energy metabolism.

Graphical abstract: Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

The intracellular redox environment modulates the cytotoxic efficacy of single and combination chemotherapy in breast cancer cells using photochemical internalisation

The redox environment modulates photochemical internalization of an entrapped cytotoxic agent. Administration of light depicted by jagged arrow.

Graphical abstract: The intracellular redox environment modulates the cytotoxic efficacy of single and combination chemotherapy in breast cancer cells using photochemical internalisation
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

A series of photosensitizers with incremental positive electric charges for photodynamic antitumor therapy

In recent years, photodynamic therapy (PDT) studies have gained considerable attention as a non-invasive method used to fight cancer.

Graphical abstract: A series of photosensitizers with incremental positive electric charges for photodynamic antitumor therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Synthesis and biological evaluation of an epidermal growth factor receptor-targeted peptide-conjugated phthalocyanine-based photosensitiser

A peptide-conjugated zinc(II) phthalocyanine has been prepared which can selectively bind to the epidermal growth factor receptor of cancer cells and induce high cytotoxicity upon illumination.

Graphical abstract: Synthesis and biological evaluation of an epidermal growth factor receptor-targeted peptide-conjugated phthalocyanine-based photosensitiser
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light

Photodynamic therapy (PDT) is a promising and effective method for tumor therapy that relies on the reactive oxygen species (ROS) produced by photosensitizers at specific wavelengths to inhibit tumor cells.

Graphical abstract: Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Berberine nanoparticles for promising sonodynamic therapy of a HeLa xenograft tumour

Here we show that berberine (BBR) nanoparticles (BBRNPs, ∼300 nm hydrodynamic diameter) is a promising sonosensitizer for cancer sonodynamic therapy (SDT).

Graphical abstract: Berberine nanoparticles for promising sonodynamic therapy of a HeLa xenograft tumour
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

SHG-enhanced NIR-excited in vitro photodynamic therapy using composite nanoparticles of barium titanate and rose Bengal

Composite nanoparticles of barium titanate and rose Bengal are used to achieve second harmonic generation (SHG) enhanced photodynamic therapy excited by near infrared (NIR) light.

Graphical abstract: SHG-enhanced NIR-excited in vitro photodynamic therapy using composite nanoparticles of barium titanate and rose Bengal
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes

An expedient approach to spot natural photosensitizers was established and with it were – for the first time – photosensitizers in mushrooms identified.

Graphical abstract: A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

A GSH-responsive nanophotosensitizer for efficient photodynamic therapy

A GSH-responsive nanophotosensitizer based on CoOOH nanosheets was developed for the photodynamic therapy of cancer.

Graphical abstract: A GSH-responsive nanophotosensitizer for efficient photodynamic therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

UCN–SiO2–GO: a core shell and conjugate system for controlling delivery of doxorubicin by 980 nm NIR pulse

A GO–UCN–SiO2 hybrid nanocomposite for loading of doxorubicin and its use in in vitro efficiency for killing carcinoma cells.

Graphical abstract: UCN–SiO2–GO: a core shell and conjugate system for controlling delivery of doxorubicin by 980 nm NIR pulse
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets

We successfully synthesized a multifunctional theranostic nanocomposite from upconversion nanoparticles and black phosphorus nanosheets for synergistic photothermal/photodynamic therapies in vitro and dual modal imaging.

Graphical abstract: Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy

Photodynamic therapy (PDT) has attracted much attention as a strategy for tumor therapy.

Graphical abstract: Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Mitochondria targeting IR780-based nanoGUMBOS for enhanced selective toxicity towards cancer cells

Mitochondria targeting nanoGUMBOS were successfully fabricated based on self-assembly of IR780 GUMBOS with different counter-anions that show promising anticancer effects.

Graphical abstract: Mitochondria targeting IR780-based nanoGUMBOS for enhanced selective toxicity towards cancer cells
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria

Antibacterial potentials of four graphene based nanomaterials are tested on a wide range of bacteria.

Graphical abstract: Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Mechanistic insight into the photodynamic effect mediated by porphyrin-fullerene C60 dyads in solution and in Staphylococcus aureus cells

The photodynamic action mechanism sensitized by a non-charged porphyrin-fullerene C60 dyad and its tetracationic analogue was investigated in solution and in Staphylococcus aureus cells.

Graphical abstract: Mechanistic insight into the photodynamic effect mediated by porphyrin-fullerene C60 dyads in solution and in Staphylococcus aureus cells
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Dual-stimuli-responsive TiOx/DOX nanodrug system for lung cancer synergistic therapy

TiOx/DOX nanosheets are synthesized and used as a novel nanodrug system, which introduces new possibilities to improve the efficacy of cancer by the synergistic therapy of chemotherapy and radiotherapy.

Graphical abstract: Dual-stimuli-responsive TiOx/DOX nanodrug system for lung cancer synergistic therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Highly efficient green synthesis and photodynamic therapeutic study of hypericin and its derivatives

A highly efficient synthetic pathway for hypericin as well as its derivatives was achieved under mild and green conditions with high yields.

Graphical abstract: Highly efficient green synthesis and photodynamic therapeutic study of hypericin and its derivatives
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Near infrared light activatable PEI-wrapped bismuth selenide nanocomposites for photothermal/photodynamic therapy induced bacterial inactivation and dye degradation

Inactivation of bacteria and degradation of organic pollutants by engineered nanomaterials (NMs) are very effective approaches in producing safe and clean drinking water.

Graphical abstract: Near infrared light activatable PEI-wrapped bismuth selenide nanocomposites for photothermal/photodynamic therapy induced bacterial inactivation and dye degradation
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Functionalization of composite bacterial cellulose with C60 nanoparticles for wound dressing and cancer therapy

A series of novel BCC60 composites as multifunctional wound dressings for skin cancer treatment were successfully fabricated using an original dehydration-rehydration method.

Graphical abstract: Functionalization of composite bacterial cellulose with C60 nanoparticles for wound dressing and cancer therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

A series of water-soluble photosensitizers based on 3-cinnamoylcoumarin for in vitro antimicrobial photodynamic inactivation

Three cationic PSs (M3–M5) exhibited equivalent photodynamic inactivation (PDI) efficacies to MRSA and A. baumannii, while M4 and M5 showed significantly higher PDI to C. albicans, compared to methylene blue, indicating their large potentials on PDI.

Graphical abstract: A series of water-soluble photosensitizers based on 3-cinnamoylcoumarin for in vitro antimicrobial photodynamic inactivation
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy

Development of photothermal agents for imaging-guided photothermal therapy (PTT) has been of great interest in the field of nanomedicine.

Graphical abstract: Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Magnetic chitosan/graphene oxide composite loaded with novel photosensitizer for enhanced photodynamic therapy

Prepared magnetic chitosan/graphene oxide composite loaded with a novel photosensitizer (MCGO–HNPa) showed excellent PDT activity against HepG-2 cells.

Graphical abstract: Magnetic chitosan/graphene oxide composite loaded with novel photosensitizer for enhanced photodynamic therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Peroxoniobium inhibits leukemia cell growth

A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy.

Graphical abstract: Peroxoniobium inhibits leukemia cell growth
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes

A novel cell permeable, mitochondria localising, diiridium complex has a high emission yield and two heavy atoms to increase scattering of electrons, supporting potential future applications as a dual fluorescence and electron microscopy probe.

Graphical abstract: Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

White light-induced cell apoptosis by a conjugated polyelectrolyte through singlet oxygen generation

A conjugated polyelectrolyte PPET3 functions as an efficient photosensitizer for photodynamic therapy and induces cell apoptosis under white light irradiation.

Graphical abstract: White light-induced cell apoptosis by a conjugated polyelectrolyte through singlet oxygen generation
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles – switchable integrin-targeted photodynamic treatment of melanoma cells

This work presents a UVA switchable integrin-targeted photodynamic therapy in melanoma, composed of an RGD-modified DLDH conjugated to TiO2 nanoparticles, with high selectivity towards integrin-expressing cancer cells.

Graphical abstract: RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles – switchable integrin-targeted photodynamic treatment of melanoma cells
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Direct C–H functionalization of difluoroboron dipyrromethenes (BODIPYs) at β-position by iodonium salts

A copper-catalyzed direct C–H arylation or vinylation of BODIPYs at the β-position by iodonium salts has been developed and β-styryl BODIPY 9b has great potential for photodynamic therapy.

Graphical abstract: Direct C–H functionalization of difluoroboron dipyrromethenes (BODIPYs) at β-position by iodonium salts
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Self-assembled organic nanorods for dual chemo-photodynamic therapies

Organic nanorods prepared by co-assembly of photosensitizer (BDP-I2) and chemical anticancer drug, paclitaxel (PTX) were evaluated for chemo-photodynamic therapies.

Graphical abstract: Self-assembled organic nanorods for dual chemo-photodynamic therapies
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study

A novel PDT photosensitizer which features great biomedical properties can be simply prepared.

Graphical abstract: Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Plasmono-magnetic material for precise photothermal heating

We demonstrated a new hybrid plasmono-magnetic material for photothermal heating created by grafting Au nanocages onto a surface of magnetic micro-beads.

Graphical abstract: Plasmono-magnetic material for precise photothermal heating
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Targeted delivery of HES5-siRNA with novel polypeptide-modified nanoparticles for hepatocellular carcinoma therapy

A novel polypeptide RGDfC-modified selenium nanoparticle was fabricated to selectively deliver HES5-siRNA to tumors for hepatocellular carcinoma therapy.

Graphical abstract: Targeted delivery of HES5-siRNA with novel polypeptide-modified nanoparticles for hepatocellular carcinoma therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

The F127-GO-DOX supramolecular hydrogel system with sustained drug release characteristic for chemotherapy and photothermal therapy.

Graphical abstract: Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy
From the themed collection: Editors’ collection: Photodynamic therapy
Open Access Paper

Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles

The delivery of photosensitizer compounds using biodegradable nanoparticles could improve dosage, controlled release and its bioavailability.

Graphical abstract: Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles
From the themed collection: Editors’ collection: Photodynamic therapy
35 items

About this collection

This collection, guest-edited by Associate Editor Dr Fabienne Dumoulin (Gebze Technical University), features articles published in the journal from 2018 on photodynamic therapy that comprise biological experiments. As an alternative therapeutic modality, recognised as an efficient way to treat not only several cancers but also infections, it has inspired the development of different treatment strategies.  

The collection reflects the variety of photosensitising systems, and the significant amount of nanophotosensitisers, including carbon nanomaterials. Various targeted approaches are being developed; theranostics are significantly expanding, as well as synergistic effects and specific activation in the tumour microenvironment. Related photothermal and sonodynamic therapies, even at less mature development stages, have proved their efficiency. Photochemical internalisation is also an excellent means to improve drug delivery and drug efficiency. Photodynamic therapy is undoubtedly a valuable way to save lives, and this collection aims at highlighting its achievements and promises.

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