A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment
Graphene–gold nanocomposite materials combined with (5-fluorouracil, 5-FU) drug show high potent cytotoxicity against MCF-7 cells, can decrease HER-2 gene expression and cause cell cycle arrest.
Novel one pot synthesis and spectroscopic characterization of a folate-Mn3O4 nanohybrid for potential photodynamic therapeutic application
Folate capped Mn3O4 nanoparticles can be used in PDT for specifically destroying folate receptor-overexpressing cancer cells through photo induced free radical damage.
Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism
Ag2S/BSA hybrid nanoparticles were prepared and studied for their ability to inhibit the growth of human lymphoma cells under light irradiation, via inducing the accumulation of intracellular reactive oxidative species to disrupt energy metabolism.
The intracellular redox environment modulates the cytotoxic efficacy of single and combination chemotherapy in breast cancer cells using photochemical internalisation
The redox environment modulates photochemical internalization of an entrapped cytotoxic agent. Administration of light depicted by jagged arrow.
A series of photosensitizers with incremental positive electric charges for photodynamic antitumor therapy
In recent years, photodynamic therapy (PDT) studies have gained considerable attention as a non-invasive method used to fight cancer.
Synthesis and biological evaluation of an epidermal growth factor receptor-targeted peptide-conjugated phthalocyanine-based photosensitiser
A peptide-conjugated zinc(II) phthalocyanine has been prepared which can selectively bind to the epidermal growth factor receptor of cancer cells and induce high cytotoxicity upon illumination.
Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light
Photodynamic therapy (PDT) is a promising and effective method for tumor therapy that relies on the reactive oxygen species (ROS) produced by photosensitizers at specific wavelengths to inhibit tumor cells.
Berberine nanoparticles for promising sonodynamic therapy of a HeLa xenograft tumour
Here we show that berberine (BBR) nanoparticles (BBRNPs, ∼300 nm hydrodynamic diameter) is a promising sonosensitizer for cancer sonodynamic therapy (SDT).
SHG-enhanced NIR-excited in vitro photodynamic therapy using composite nanoparticles of barium titanate and rose Bengal
Composite nanoparticles of barium titanate and rose Bengal are used to achieve second harmonic generation (SHG) enhanced photodynamic therapy excited by near infrared (NIR) light.
A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes
An expedient approach to spot natural photosensitizers was established and with it were – for the first time – photosensitizers in mushrooms identified.
A GSH-responsive nanophotosensitizer for efficient photodynamic therapy
A GSH-responsive nanophotosensitizer based on CoOOH nanosheets was developed for the photodynamic therapy of cancer.
UCN–SiO2–GO: a core shell and conjugate system for controlling delivery of doxorubicin by 980 nm NIR pulse
A GO–UCN–SiO2 hybrid nanocomposite for loading of doxorubicin and its use in in vitro efficiency for killing carcinoma cells.
Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets
We successfully synthesized a multifunctional theranostic nanocomposite from upconversion nanoparticles and black phosphorus nanosheets for synergistic photothermal/photodynamic therapies in vitro and dual modal imaging.
Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy
Photodynamic therapy (PDT) has attracted much attention as a strategy for tumor therapy.
Mitochondria targeting IR780-based nanoGUMBOS for enhanced selective toxicity towards cancer cells
Mitochondria targeting nanoGUMBOS were successfully fabricated based on self-assembly of IR780 GUMBOS with different counter-anions that show promising anticancer effects.
Photo-induced antibacterial activity of four graphene based nanomaterials on a wide range of bacteria
Antibacterial potentials of four graphene based nanomaterials are tested on a wide range of bacteria.
Mechanistic insight into the photodynamic effect mediated by porphyrin-fullerene C60 dyads in solution and in Staphylococcus aureus cells
The photodynamic action mechanism sensitized by a non-charged porphyrin-fullerene C60 dyad and its tetracationic analogue was investigated in solution and in Staphylococcus aureus cells.
Dual-stimuli-responsive TiOx/DOX nanodrug system for lung cancer synergistic therapy
TiOx/DOX nanosheets are synthesized and used as a novel nanodrug system, which introduces new possibilities to improve the efficacy of cancer by the synergistic therapy of chemotherapy and radiotherapy.
Highly efficient green synthesis and photodynamic therapeutic study of hypericin and its derivatives
A highly efficient synthetic pathway for hypericin as well as its derivatives was achieved under mild and green conditions with high yields.
Near infrared light activatable PEI-wrapped bismuth selenide nanocomposites for photothermal/photodynamic therapy induced bacterial inactivation and dye degradation
Inactivation of bacteria and degradation of organic pollutants by engineered nanomaterials (NMs) are very effective approaches in producing safe and clean drinking water.
Functionalization of composite bacterial cellulose with C60 nanoparticles for wound dressing and cancer therapy
A series of novel BCC60 composites as multifunctional wound dressings for skin cancer treatment were successfully fabricated using an original dehydration-rehydration method.
A series of water-soluble photosensitizers based on 3-cinnamoylcoumarin for in vitro antimicrobial photodynamic inactivation
Three cationic PSs (M3–M5) exhibited equivalent photodynamic inactivation (PDI) efficacies to MRSA and A. baumannii, while M4 and M5 showed significantly higher PDI to C. albicans, compared to methylene blue, indicating their large potentials on PDI.
Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy
Development of photothermal agents for imaging-guided photothermal therapy (PTT) has been of great interest in the field of nanomedicine.
Magnetic chitosan/graphene oxide composite loaded with novel photosensitizer for enhanced photodynamic therapy
Prepared magnetic chitosan/graphene oxide composite loaded with a novel photosensitizer (MCGO–HNPa) showed excellent PDT activity against HepG-2 cells.
Peroxoniobium inhibits leukemia cell growth
A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy.
Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes
A novel cell permeable, mitochondria localising, diiridium complex has a high emission yield and two heavy atoms to increase scattering of electrons, supporting potential future applications as a dual fluorescence and electron microscopy probe.
White light-induced cell apoptosis by a conjugated polyelectrolyte through singlet oxygen generation
A conjugated polyelectrolyte PPET3 functions as an efficient photosensitizer for photodynamic therapy and induces cell apoptosis under white light irradiation.
RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles – switchable integrin-targeted photodynamic treatment of melanoma cells
This work presents a UVA switchable integrin-targeted photodynamic therapy in melanoma, composed of an RGD-modified DLDH conjugated to TiO2 nanoparticles, with high selectivity towards integrin-expressing cancer cells.
Direct C–H functionalization of difluoroboron dipyrromethenes (BODIPYs) at β-position by iodonium salts
A copper-catalyzed direct C–H arylation or vinylation of BODIPYs at the β-position by iodonium salts has been developed and β-styryl BODIPY 9b has great potential for photodynamic therapy.
Self-assembled organic nanorods for dual chemo-photodynamic therapies
Organic nanorods prepared by co-assembly of photosensitizer (BDP-I2) and chemical anticancer drug, paclitaxel (PTX) were evaluated for chemo-photodynamic therapies.
Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study
A novel PDT photosensitizer which features great biomedical properties can be simply prepared.
Plasmono-magnetic material for precise photothermal heating
We demonstrated a new hybrid plasmono-magnetic material for photothermal heating created by grafting Au nanocages onto a surface of magnetic micro-beads.
Targeted delivery of HES5-siRNA with novel polypeptide-modified nanoparticles for hepatocellular carcinoma therapy
A novel polypeptide RGDfC-modified selenium nanoparticle was fabricated to selectively deliver HES5-siRNA to tumors for hepatocellular carcinoma therapy.
Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy
The F127-GO-DOX supramolecular hydrogel system with sustained drug release characteristic for chemotherapy and photothermal therapy.
Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles
The delivery of photosensitizer compounds using biodegradable nanoparticles could improve dosage, controlled release and its bioavailability.
About this collection
This collection, guest-edited by Associate Editor Dr Fabienne Dumoulin (Gebze Technical University), features articles published in the journal from 2018 on photodynamic therapy that comprise biological experiments. As an alternative therapeutic modality, recognised as an efficient way to treat not only several cancers but also infections, it has inspired the development of different treatment strategies.
The collection reflects the variety of photosensitising systems, and the significant amount of nanophotosensitisers, including carbon nanomaterials. Various targeted approaches are being developed; theranostics are significantly expanding, as well as synergistic effects and specific activation in the tumour microenvironment. Related photothermal and sonodynamic therapies, even at less mature development stages, have proved their efficiency. Photochemical internalisation is also an excellent means to improve drug delivery and drug efficiency. Photodynamic therapy is undoubtedly a valuable way to save lives, and this collection aims at highlighting its achievements and promises.