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Issue 39, 2018
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Dual-stimuli-responsive TiOx/DOX nanodrug system for lung cancer synergistic therapy

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Abstract

Biological applications of nanosheets are rapidly increasing currently, which introduces new possibilities to improve the efficacy of cancer chemotherapy and radiotherapy. Herein, we designed and synthesized a novel nano-drug system, doxorubicin (DOX) loaded titanium peroxide (TiOx) nanosheets, toward the synergistic treatment of lung cancer. The precursor of TiO2 nanosheets with high specific surface area was synthesized by a modified hydrothermal process using the polymer P123 as a soft template to control the shape. TiOx nanosheets were obtained by oxidizing TiO2 nanosheets with H2O2. The anti-cancer drug DOX was effectively loaded on the surface of TiOx nanosheets. Generation of reactive oxygen species, including H2O2, ·OH and ·O2, was promoted from TiOx nanosheets under X-ray irradiation, which is effective for cancer radiotherapy and drug release in cancer cells. In this way, chemotherapy and radiotherapy were combined effectively for the synergistic therapy of cancers. Our results reinforce the DOX loaded TiOx nanosheets as a pH sensitive and X-ray controlled dual-stimuli-responsive drug release system. The cytotoxicity, cellular uptake, and intracellular location of the formulations were evaluated in the A549 human non-small cell lung cancer cell line. Our results showed that TiOx/DOX complexes exhibited a greater cytotoxicity toward A549 cells than free DOX. This work demonstrates that the therapeutic efficacy of DOX-loaded TiOx nanosheets is strongly dependent on their loading mode and the chemotherapeutic and radiotherapy effect is improved under X-ray illumination, which provides a significant breakthrough for future applications of TiOx as a light activated drug carrier in cancer chemotherapy and radiotherapy.

Graphical abstract: Dual-stimuli-responsive TiOx/DOX nanodrug system for lung cancer synergistic therapy

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Supplementary files

Article information


Submitted
04 Apr 2018
Accepted
09 Jun 2018
First published
14 Jun 2018

This article is Open Access

RSC Adv., 2018,8, 21975-21984
Article type
Paper

Dual-stimuli-responsive TiOx/DOX nanodrug system for lung cancer synergistic therapy

Z. Dai, X. Song, J. Cao, Y. He, W. Wen, X. Xu and Z. Tan, RSC Adv., 2018, 8, 21975
DOI: 10.1039/C8RA02899K

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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