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Issue 3, 2018
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Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

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Abstract

A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO) supramolecular hydrogel as a safe nanovehicle for combination treatment has been studied. Doxorubicin (DOX) as a model drug is non-covalently bound on the great surface area of GO due to strong π–π interaction, hydrophobic interaction, and the strongest hydrogen bonding. In vitro drug release experiments revealed that this F127-stabilized GO supramolecular hydrogel has a sustained drug release characteristic. Furthermore, the supramolecular hydrogel showed better in vitro antitumor ability under NIR (near infrared) laser irradiation because of the excellent photothermal effect of GO. Moreover, we evaluated its antitumor ability in vivo and the results show that the hydrogel system can also markedly inhibit the growth of a tumor when administered individually, especially under laser irradiation. All these findings make the supramolecular hydrogel system promising for combination therapy with good bioavailability and minimal side effects.

Graphical abstract: Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

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Article information


Submitted
03 Nov 2017
Accepted
20 Dec 2017
First published
05 Jan 2018

This article is Open Access

RSC Adv., 2018,8, 1693-1699
Article type
Paper

Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

B. Li, L. Zhang, Z. Zhang, R. Gao, H. Li, Z. Dong, Q. Wang, Q. Zhou and Y. Wang, RSC Adv., 2018, 8, 1693
DOI: 10.1039/C7RA12099K

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    [Original citation] - Published by The Royal Society of Chemistry.

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