Jump to main content
Jump to site search

Issue 51, 2019
Previous Article Next Article

Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

Author affiliations

Abstract

Recently, studies on the application of light-responsive semiconductor nanomaterials for photodynamic therapy (PDT) of non-solid tumors have attracted tremendous attention. Herein, 6.98 nm Ag2S nanoparticles (Ag2S NPs) with excellent aqueous dispersibility, stability, and biocompatibility were synthesized by a facile strategy without any post-modification. In vitro studies indicated that Ag2S NPs could significantly inhibit the growth of human lymphoma cells (Raji cells) compared with hepatoma carcinoma cells (Hep G2 cells) under light irradiation. Further studies revealed that Ag2S NPs could specifically induce the accumulation of intracellular reactive oxidative species in Raji cells under light irradiation, and induce significant disruption of energy metabolism. This finding provides inspiration for the potential application of Ag2S semiconductor nanoparticles as a photosensitizer to significantly and specifically treat human lymphoma through PDT.

Graphical abstract: Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

Back to tab navigation

Article information


Submitted
16 Jul 2019
Accepted
09 Sep 2019
First published
23 Sep 2019

This article is Open Access

RSC Adv., 2019,9, 29936-29941
Article type
Paper

Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

G. Wang, J. Liu, L. Zhu, Y. Guo and L. Yang, RSC Adv., 2019, 9, 29936
DOI: 10.1039/C9RA05432D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements