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Issue 8, 2019, Issue in Progress
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A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes

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Abstract

Photodynamic therapy (PDT) is an alternative approach for the treatment of neoplastic diseases employing photosensitizers activated by light. In order to discover new natural photosensitizers, a convenient workflow was established. To validate the workflow, fungi were selected, because we hypothesized that fruiting bodies and mycelia are an overlooked source. The results proved the hypothesis, as exorbitant high photo-cytotoxicity values were detected. For example, the acetone extract of Cortinarius croceus was characterized by an EC50, 9.3 J cm−2 of 1 µg mL−1 against cells of a lung cancer cell-line (A549). In sum, a low-cost workflow for the detection and biological evaluation of photosensitizers is presented and discussed. Furthermore, this paper provides the first experimental evidence for phototoxic metabolites in basidiomycetes. This hints towards a new assignable function of fungal pigments, i.e. photochemical defense.

Graphical abstract: A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes

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Publication details

The article was received on 11 Dec 2018, accepted on 24 Jan 2019 and first published on 05 Feb 2019


Article type: Paper
DOI: 10.1039/C8RA10181G
RSC Adv., 2019,9, 4545-4552
  • Open access: Creative Commons BY license
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    A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes

    B. Siewert, P. Vrabl, F. Hammerle, I. Bingger and H. Stuppner, RSC Adv., 2019, 9, 4545
    DOI: 10.1039/C8RA10181G

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