Jump to main content
Jump to site search

Issue 10, 2018
Previous Article Next Article

Self-assembled organic nanorods for dual chemo-photodynamic therapies

Author affiliations

Abstract

Photodynamic therapy (PDT) and chemotherapy have been extensively developed as effective approaches against cancer. Herein, we constructed organic nanorods by rational co-assembly of photosensitizer, di-iodinated borondipyrromethene (BDP-I2), and chemical anticancer drug, paclitaxel (PTX). The physico- and photochemical properties of the obtained nanorods were carefully investigated. BDP-I2 was selected for its high singlet oxygen (1O2) quantum yields. And the corresponding 1O2 generation ability and photodynamic effect were evaluated both in vitro and in vivo. The accelerated endosomal escape of the nanorods induced by the photodynamic effect enhanced the chemotherapeutic efficacy of PTX. We believe that this synergetic nanomedicine represents a new development for antitumor chemophotodynamic therapy.

Graphical abstract: Self-assembled organic nanorods for dual chemo-photodynamic therapies

Back to tab navigation

Supplementary files

Article information


Submitted
04 Jan 2018
Accepted
25 Jan 2018
First published
01 Feb 2018

This article is Open Access

RSC Adv., 2018,8, 5493-5499
Article type
Paper

Self-assembled organic nanorods for dual chemo-photodynamic therapies

Y. Li, X. Hu, X. Zheng, Y. Liu, S. Liu, Y. Yue and Z. Xie, RSC Adv., 2018, 8, 5493
DOI: 10.1039/C8RA00067K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements