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Issue 53, 2019
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A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

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Abstract

There is no doubt that cancer is now one of the most formidable diseases in the world; despite all the efforts and research, common treatment routes, including chemotherapy, photodynamic therapy, and photothermal therapy, suffer from different limitations in terms of their efficiency and performance. For this reason, different strategies are being explored to improve the efficiency of the traditional drugs reported to date. In this study, we have redirected the function of one of these drugs (5-fluorouracil, 5-FU) by combining it with a graphene–gold nanocomposite in different molar ratios that has been exceedingly used for biological research development. The high activity of the graphene–gold material enables it to produce reactive oxygen and ions, which display good anticancer and antioxidant activity through the scavenging of the DPPH, SOD and GPx radicals; in addition, different characterizations have been used to confirm the structure and morphology of the obtained samples. Highly potent cytotoxicity against the MCF-7 cells was achieved with the drug combination containing the nanocomposite. All the results, including those obtained via cytometry, indicate that the combination of 5% graphene–gold nanocomposites with 5-FU exhibits a higher antitumor impact and more drug stability than pure 5-FU.

Graphical abstract: A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

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Article information


Submitted
22 Jul 2019
Accepted
31 Aug 2019
First published
02 Oct 2019

This article is Open Access

RSC Adv., 2019,9, 31021-31029
Article type
Paper

A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

M. F. Sanad, A. E. Shalan, S. M. Bazid, E. S. Abu Serea, E. M. Hashem, S. Nabih and M. A. Ahsan, RSC Adv., 2019, 9, 31021
DOI: 10.1039/C9RA05669F

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