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Issue 19, 2018
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Peroxoniobium inhibits leukemia cell growth

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Abstract

A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.

Graphical abstract: Peroxoniobium inhibits leukemia cell growth

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Article information


Submitted
29 Jan 2018
Accepted
08 Mar 2018
First published
14 Mar 2018

This article is Open Access

RSC Adv., 2018,8, 10310-10313
Article type
Paper

Peroxoniobium inhibits leukemia cell growth

E. C. Pereira-Maia, I. P. Souza, K. J. R. C. Nunes, A. A. Castro, T. C. Ramalho, F. Steffler, H. A. Duarte, A. Pacheli, P. Chagas and L. C. A. Oliveira, RSC Adv., 2018, 8, 10310
DOI: 10.1039/C8RA00898A

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    [Original citation] - Published by The Royal Society of Chemistry.

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