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Themed collection 2019 Chemical Science HOT Article Collection

65 items
Open Access Minireview

Visual kinetic analysis

Naked-eye comparison of reaction profiles is a powerful tool to extract mechanistic information – FAQ, video tutorial and templated examples included.

Graphical abstract: Visual kinetic analysis
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Carbon monoxide insertion at a heavy p-block element: unprecedented formation of a cationic bismuth carbamoyl

The first insertion reaction of CO with a molecular complex of the heavy p-block elements is reported (principal quantum number > 4).

Graphical abstract: Carbon monoxide insertion at a heavy p-block element: unprecedented formation of a cationic bismuth carbamoyl
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Facile synthesis of AIEgens with wide color tunability for cellular imaging and therapy

Facile synthesis and bio-applications of a series of AIEgens with widely tunable emissions ranging from violet to near-infrared are reported.

Graphical abstract: Facile synthesis of AIEgens with wide color tunability for cellular imaging and therapy
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

A chemical reaction controlled by light-activated molecular switches based on hetero-cyclopentanediyls

Biradicals were applied as molecular switches to control chemical reactions that involve the activation of small molecules. The mechanism was studied by experimental and computational methods.

Graphical abstract: A chemical reaction controlled by light-activated molecular switches based on hetero-cyclopentanediyls
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

A dinuclear ruthenium(II) phototherapeutic that targets duplex and quadruplex DNA

A previously reported dinuclear DNA imaging probe has been converted into a phototherapeutic through the incorporation of RuII(TAP)2 fragments (TAP = 1,4,5,8-3 tetraazaphenanthrene).

Graphical abstract: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors

A new catalyst that derives from commercially available precursors for copper-free, Pd-catalyzed Sonogashira reactions at the sustainable ppm level of precious metal palladium under mild aqueous micellar conditions has been developed.

Graphical abstract: ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Catalytic asymmetric allylation of aldehydes with alkenes through allylic C(sp3)–H functionalization mediated by organophotoredox and chiral chromium hybrid catalysis

We have developed a catalytic asymmetric nucleophilic allylation of aldehydes using simple alkenes as pronucleophiles without relying on stoichiometric metals.

Graphical abstract: Catalytic asymmetric allylation of aldehydes with alkenes through allylic C(sp3)–H functionalization mediated by organophotoredox and chiral chromium hybrid catalysis
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Using coligands to gain mechanistic insight into iridium complexes hyperpolarized with para-hydrogen

From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Helical Orbitals and Circular Currents in Linear Carbon Wires

From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Construction of a cross-layer linked G-octamer via conformational control: a stable G-quadruplex in H-bond competitive solvents

A discrete and well-defined G-octamer system has been established through conformational design of monomers. The crystal structures of G-octamers were obtained for the first time. The covalent linked G-quadruplex exhibited significantly improved stability in both methanol and DMSO.

Graphical abstract: Construction of a cross-layer linked G-octamer via conformational control: a stable G-quadruplex in H-bond competitive solvents
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Deep Neural Network Learning of Complex Binary Sorption Equilibria from Molecular Simulation Data

From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Photoinitiated Carbonyl-Metathesis: Deoxygenative Reductive Olefination of Aromatic Aldehydes via Photoredox Catalysis

From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Anisotropic strain release in a thermosalient crystal: correlation between the microscopic orientation of molecular rearrangements and the macroscopic mechanical motion

We report the salient effect of the crystal of gold complex that bridges the gap between macroscopic mechanical movements (i.e., jump) and microscopic changes of the crystal structure.

Graphical abstract: Anisotropic strain release in a thermosalient crystal: correlation between the microscopic orientation of molecular rearrangements and the macroscopic mechanical motion
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Highly selective palladium-catalyzed one-pot, five-fold B–H/C–H cross coupling of monocarboranes with alkenes

Palladium-catalyzed five-fold B–H/C–H cross coupling of monocarboranes with alkenes enables the synthesis of selectively penta-functionalized boron clusters.

Graphical abstract: Highly selective palladium-catalyzed one-pot, five-fold B–H/C–H cross coupling of monocarboranes with alkenes
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

A catalytic protein–proteomimetic complex: using aromatic oligoamide foldamers as activators of RNase S

An aromatic oligoamide foldamer acts as an α-helix mimetic and binds to the RNase S-protein resulting in restoration of its catalytic function.

Graphical abstract: A catalytic protein–proteomimetic complex: using aromatic oligoamide foldamers as activators of RNase S
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes

We have developed a nickel-catalyzed anti-Markovnikov hydroarylation of alkenes using aryl halides as coupling partners.

Graphical abstract: Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Catalytic radical difluoromethoxylation of arenes and heteroarenes

The first visible light photocatalytic generation and utilization of the OCF2H radical for direct (hetero)aryl C–H difluoromethoxylation at room temperature.

Graphical abstract: Catalytic radical difluoromethoxylation of arenes and heteroarenes
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Hydroxyl-mediated ethanol selectivity of CO2 hydrogenation

This paper describes the promotional effect of hydroxyl groups over RhFeLi/TiO2 catalysts for the ethanol synthesis via CO2 hydrogenation.

Graphical abstract: Hydroxyl-mediated ethanol selectivity of CO2 hydrogenation
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers

Highly stereoselective synthesis of Z-enamides and enol ethers at room temperature via an umpolung/cross coupling strategy applicable to drugs and natural products.

Graphical abstract: Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Acyclic 1,2-dimagnesioethanes/-ethene derived from magnesium(I) compounds: multipurpose reagents for organometallic synthesis

The sometimes redox reversible 1,2-additions of magnesium(I) dimers across several alkenes and one alkyne yield 1,2-dimagnesioethanes and a 1,2-dimagnesioethene. Treatment of these with bulky amido metal halide precursors affords novel products via three reactivity modes.

Graphical abstract: Acyclic 1,2-dimagnesioethanes/-ethene derived from magnesium(i) compounds: multipurpose reagents for organometallic synthesis
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Enantioselective intramolecular C–H amination of aliphatic azides by dual ruthenium and phosphine catalysis

By combining a chiral-at-metal ruthenium catalyst with catalytic amounts of tris(p-fluorophenyl)phosphine (both 1 mol%), the challenging catalytic enantioselective ring-closing C(sp3)-H amination of unactivated aliphatic azides has been achieved with high enantioselectivities.

Graphical abstract: Enantioselective intramolecular C–H amination of aliphatic azides by dual ruthenium and phosphine catalysis
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

An Al-doped SrTiO3 photocatalyst maintaining sunlight-driven overall water splitting activity for over 1000 h of constant illumination

The development of robust and efficient water splitting photocatalysts overcomes a long-standing barrier to sustainable large-scale solar hydrogen evolution systems.

Graphical abstract: An Al-doped SrTiO3 photocatalyst maintaining sunlight-driven overall water splitting activity for over 1000 h of constant illumination
From the themed collection: 2019 ChemSci Pick of the Week Collection
Open Access Edge Article

Constructing new metal–organic frameworks with complicated ligands from “One-Pot” in situ reactions

A “One-Pot” strategy has been developed to construct new metal–organic frameworks with complicated ligands from simple precursors by integrating organic and coordination chemistry.

Graphical abstract: Constructing new metal–organic frameworks with complicated ligands from “One-Pot” in situ reactions
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Aqueous acid-based synthesis of lead-free tin halide perovskites with near-unity photoluminescence quantum efficiency

From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460

One amino acid makes the difference between a metalloenzyme and a metalloprotein in two otherwise effectively identical cytochrome P460s.

Graphical abstract: Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Dinuclear manganese alkoxide complexes as catalysts for C–N bond cleavage of simple tertiary N,N-dialkylamides to give esters

Amide bonds are stable due to the resonance between the nitrogen lone pair and the carbonyl moiety, and therefore the chemical transformation of amides, especially tertiary amides, involving C–N bond fission is considered one of the most difficult organic reactions, unavoidably requiring harsh reaction conditions and strong acids or bases.

Graphical abstract: Dinuclear manganese alkoxide complexes as catalysts for C–N bond cleavage of simple tertiary N,N-dialkylamides to give esters
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Cooperativity basis for small-molecule stabilization of protein–protein interactions

A cooperativity framework to describe and interpret small-molecule stabilization of protein–protein interactions (PPI) is presented, which allows elucidating structure–activity relationships regarding cooperativity and intrinsic affinity.

Graphical abstract: Cooperativity basis for small-molecule stabilization of protein–protein interactions
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Insights into mechanochemical reactions at the molecular level: simulated indentations of aspirin and meloxicam crystals

Working towards a fundamental description of mechanochemical reactions through the use of classical molecular dynamics simulations. Capturing the transfer of molecules between two non-volatile molecular crystals during mechanochemical events.

Graphical abstract: Insights into mechanochemical reactions at the molecular level: simulated indentations of aspirin and meloxicam crystals
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

From nano-balls to nano-bowls

Depending on the reaction conditions, either guest or host truncation is observed upon self-assembly of [Cp*Fe(η5-P5)], [(CpCr)25-As5)] and copper halides.

Graphical abstract: From nano-balls to nano-bowls
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi

Three novel dimeric xanthones, cryptosporioptides A–C were isolated from Cryptosporiopsis sp. 8999 and their structures elucidated.

Graphical abstract: Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Through-space charge transfer hexaarylbenzene dendrimers with thermally activated delayed fluorescence and aggregation-induced emission for efficient solution-processed OLEDs

Through-space charge transfer hexaarylbenzene dendrimers containing circularly-arrayed electron donors and acceptors exhibit thermally activated delayed fluorescence and aggregation-induced emission effects, giving EQE of 14.2% for solution-processed OLEDs.

Graphical abstract: Through-space charge transfer hexaarylbenzene dendrimers with thermally activated delayed fluorescence and aggregation-induced emission for efficient solution-processed OLEDs
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

A molecular picture of surface interactions of organic compounds on prevalent indoor surfaces: limonene adsorption on SiO2

Integration of experiment, theory and modeling to understand the interaction type and kinetics of limonene on silica surfaces.

Graphical abstract: A molecular picture of surface interactions of organic compounds on prevalent indoor surfaces: limonene adsorption on SiO2
From the themed collection: 2019 ChemSci Pick of the Week Collection
Open Access Edge Article

Influence of intramolecular secondary sphere hydrogen-bonding interactions on cytochrome c oxidase inspired low-spin heme–peroxo–copper complexes

Structural/electronic influence of metalloenzyme-inspired synthetic heme–peroxo–copper models containing intramolecular hydrogen bonding interactions.

Graphical abstract: Influence of intramolecular secondary sphere hydrogen-bonding interactions on cytochrome c oxidase inspired low-spin heme–peroxo–copper complexes
From the themed collection: 2019 ChemSci Pick of the Week Collection
Open Access Edge Article

Revising the measurement process in the variational quantum eigensolver: is it possible to reduce the number of separately measured operators?

We have introduced two approaches to reduce the number of separately measured terms in molecular Hamiltonians within the Variational Quantum Eigensolver (VQE) technique for solving the electronic structure problem.

Graphical abstract: Revising the measurement process in the variational quantum eigensolver: is it possible to reduce the number of separately measured operators?
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Thorium- and uranium-azide reductions: a transient dithorium-nitride versus isolable diuranium-nitrides

Evidence for a transient, highly reactive ThNTh nitride is presented, in contrast to uranium analogues that are stable and isolable. Surprisingly, computational studies reveal a σ > π energy ordering for all these bridging nitride bonds, a phenomenon for actinides only observed before in terminal uranium nitrides and uranyl.

Graphical abstract: Thorium- and uranium-azide reductions: a transient dithorium-nitride versus isolable diuranium-nitrides
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Achieving efficient and robust catalytic reforming on dual-sites of Cu species

This paper describes how Cu+ species act as electrophilic sites to facilitate the adsorption and activation of formate and restrict the Ostwald ripening of Cu species, leading to an efficient and robust steam reforming of bio-DME.

Graphical abstract: Achieving efficient and robust catalytic reforming on dual-sites of Cu species
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Heterolytic bond activation at gold: evidence for gold(III) H–B, H–Si complexes, H–H and H–C cleavage

Gold(III) forms spectroscopically detectable H–B and H–Si σ-complexes; experiments and DFT calculations demonstrate heterolytic H–Si, H–H and H–C bond cleavage.

Graphical abstract: Heterolytic bond activation at gold: evidence for gold(iii) H–B, H–Si complexes, H–H and H–C cleavage
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Controlling catalytic activity and selectivity for partial hydrogenation by tuning the environment around active sites in iridium complexes bonded to supports

Enveloping atomically dispersed supported iridium with the choice of ionic liquid molecular sheaths and supports controls the catalytic performance.

Graphical abstract: Controlling catalytic activity and selectivity for partial hydrogenation by tuning the environment around active sites in iridium complexes bonded to supports
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Low overpotential water oxidation at neutral pH catalyzed by a copper(II) porphyrin

Low-overpotential water oxidation catalyzed by copper(II) porphyrin to produce O2 in neutral aqueous solution and H2O2 in acidic solution.

Graphical abstract: Low overpotential water oxidation at neutral pH catalyzed by a copper(ii) porphyrin
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Highly reversible potassium-ion intercalation in tungsten disulfide

0.62 K+ readily (de)intercalates in WS2 with well-defined voltage plateaus, an intrinsically safe operation potential, and ultrahigh reversibility.

Graphical abstract: Highly reversible potassium-ion intercalation in tungsten disulfide
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media.

Graphical abstract: Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media
From the themed collection: 2019 ChemSci Pick of the Week Collection
Open Access Edge Article

Dithiane-directed Rh(III)-catalyzed amidation of unactivated C(sp3)–H bonds

A Rh(III) catalysed dithiane directed C(sp3)–H amidation for the synthesis of usefully protected β-aminoaldehyde derivatives is described.

Graphical abstract: Dithiane-directed Rh(iii)-catalyzed amidation of unactivated C(sp3)–H bonds
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Enantioselective [1,3] O-to-C rearrangement: dearomatization of alkyl 2-allyloxy/benzyloxy-1/3-naphthoates catalyzed by a chiral π–Cu(II) complex

An asymmetric [1,3] O-to-C rearrangement of alkyl 2-allyloxy/benzyloxy-1/3-naphthoates was realized under the catalysis of a chiral π–Cu(II) complex to produce naphthalenone derivatives bearing an all-carbon quaternary stereogenic center in good to high yield with excellent enantioselectivity. The π–cation interaction of the complex was proved by X-ray diffraction analysis.

Graphical abstract: Enantioselective [1,3] O-to-C rearrangement: dearomatization of alkyl 2-allyloxy/benzyloxy-1/3-naphthoates catalyzed by a chiral π–Cu(ii) complex
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Synergistic self-seeding in one-dimension: a route to patchy and block comicelles with uniform and controllable length

By manipulating both the dissolution sequence of polymer crystallites and the growth rate of polymer unimers, patchy comicelles and block comicelles with uniform and controllable length can be obtained.

Graphical abstract: Synergistic self-seeding in one-dimension: a route to patchy and block comicelles with uniform and controllable length
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Electrocatalytic hydrogen evolution with gallium hydride and ligand-centered reduction

GaIII porphyrin is active for electrocatalytic hydrogen evolution with unusual features, including ligand-centered electron transfer and formation of post-transition metal hydride.

Graphical abstract: Electrocatalytic hydrogen evolution with gallium hydride and ligand-centered reduction
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures

Novel photocaged lipids have been developed to release sphingosine at specific locations revealing a metabolic bias in ceramide synthesis based on subcellular location.

Graphical abstract: Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

How machine learning can assist the interpretation of ab initio molecular dynamics simulations and conceptual understanding of chemistry

Machine learning models, trained to reproduce molecular dynamics results, help interpreting simulations and extracting new understanding of chemistry.

Graphical abstract: How machine learning can assist the interpretation of ab initio molecular dynamics simulations and conceptual understanding of chemistry
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

An integrated-molecular-beacon based multiple exponential strand displacement amplification strategy for ultrasensitive detection of DNA methyltransferase activity

An ultra-sensitive biosensor using only two DNA oligos to initiate multiple signal amplification cycles.

Graphical abstract: An integrated-molecular-beacon based multiple exponential strand displacement amplification strategy for ultrasensitive detection of DNA methyltransferase activity
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Frontier molecular orbital effects control the hole-catalyzed racemization of atropisomeric biaryls

Biaryl atropisomerization is dramatically accelerated by the removal of an electron. The planar transition state is preferentially stabilized from depopulation of the highest occupied molecular orbital.

Graphical abstract: Frontier molecular orbital effects control the hole-catalyzed racemization of atropisomeric biaryls
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Optical control of the antigen translocation by synthetic photo-conditional viral inhibitors

By designing and engineering photo-conditional viral inhibitors, spatiotemporal control of the transporter associated with antigen processing TAP was sustained, allowing the on-demand antigen translocation in human immune cell lines and primary cells by light.

Graphical abstract: Optical control of the antigen translocation by synthetic photo-conditional viral inhibitors
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport

A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes.

Graphical abstract: Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Exploration of solid-state nanopores in characterizing reaction mixtures generated from a catalytic DNA assembly circuit

We adapt a solid-state nanopore for analyzing DNA assembly mixtures, which is usually a tougher task for either traditional characterization methods or nanopores themselves. A trigger induced nucleic acid amplifier, SP-CHA, is designed as a model. We propose an electrophoresis-gel like, but homogeneous, quantitative method that can comprehensively profile the “base-pair distribution” of SP-CHA concatemer mixtures.

Graphical abstract: Exploration of solid-state nanopores in characterizing reaction mixtures generated from a catalytic DNA assembly circuit
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Waterproof architectures through subcomponent self-assembly

Construction of metal–organic containers that are soluble and stable in water can be challenging – we present diverse strategies that allow the synthesis of kinetically robust water-soluble architectures via subcomponent self-assembly.

Graphical abstract: Waterproof architectures through subcomponent self-assembly
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Size-dependent synthesis and catalytic activities of trimetallic PdAgCu mesoporous nanospheres in ethanol electrooxidation

A facile solution-phase synthetic approach is reported to engineer the size effect of sub-100 nm PdAgCu mesoporous nanospheres in ethanol electrooxidation.

Graphical abstract: Size-dependent synthesis and catalytic activities of trimetallic PdAgCu mesoporous nanospheres in ethanol electrooxidation
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Reaction-free and MMP-independent fluorescent probes for long-term mitochondria visualization and tracking

We present two mitochondria-immobilized fluorescent probes ECPI-12 and IVPI-12 for long-term mitochondria visualization and tracking regardless of MMP changes.

Graphical abstract: Reaction-free and MMP-independent fluorescent probes for long-term mitochondria visualization and tracking
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(VI) catalyst

Total synthesis of two thiopeptide antibiotics, micrococcin P1 and thiocillin I, is described featuring new molybdenum catalyst.

Graphical abstract: Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

An enzyme-free molecular catalytic device: dynamically self-assembled DNA dendrimers for in situ imaging of microRNAs in live cells

Branched catalytic hairpin assembly is proposed for dynamic self-assembly of DNA dendrimers for signal amplification and in situ imaging of microRNAs in live cells with high sensitivity and selectivity.

Graphical abstract: An enzyme-free molecular catalytic device: dynamically self-assembled DNA dendrimers for in situ imaging of microRNAs in live cells
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Color-tunable lanthanide metal–organic framework gels

MOF gels with intrinsic emission color are prepared with 5-boronoisophthalic acid and Eu3+, Tb3+, and/or Dy3+. Single-metal gels exhibit trichromatic fluorescence, so full color emissions are readily obtained by tuning the type and/or ratio of Ln3+ ions to prepare mixed-metal gels. Nano-ribbons form from the precursors and then entangle together to generate the gels.

Graphical abstract: Color-tunable lanthanide metal–organic framework gels
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

Polyketide–polyketide hybrids are unique natural products with promising bioactivity, but the hybridization processes remain poorly understood.

Graphical abstract: Dalmanol biosyntheses require coupling of two separate polyketide gene clusters
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

The condensation domain synthesising the last peptide bond in glycopeptide antibiotic biosynthesis has a preference for linear peptide substrates, with effective peptide formation linked to the rate of amino acid activation by the preceding adenylation domain.

Graphical abstract: The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Direct observation of the intermediate in an ultrafast isomerization

Using a combination of two-dimensional infrared (2D IR) and variable temperature Fourier transform infrared (FTIR) spectroscopies the rapid structural isomerization of a five-coordinate ruthenium complex is investigated.

Graphical abstract: Direct observation of the intermediate in an ultrafast isomerization
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Photoelectrocatalytic H2 evolution from integrated photocatalysts adsorbed on NiO

A new approach to increasing the faradaic efficiency of dye-sensitised photocathodes for H2 evolution from water is described, using integrated photocatalysts based on a ruthenium 4,4′-diethoxycarboxy-2,2′-bipyridine chromophore linked via terpyridine or triazole to a Pd or Pt-based H+ reduction catalyst.

Graphical abstract: Photoelectrocatalytic H2 evolution from integrated photocatalysts adsorbed on NiO
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones

The study of a selective palladium(II)-catalyzed C(sp3)–H acetoxylation reaction on a class of cyclic alkyl amines is reported.

Graphical abstract: Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Multiple adaptation of constitutional dynamic networks and information storage in constitutional distributions of acylhydrazones

Acylhydrazone-based constitutional dynamic networks respond to three agents by interesting multi-adaptive behavior for processing molecular information through constituent distributions.

Graphical abstract: Multiple adaptation of constitutional dynamic networks and information storage in constitutional distributions of acylhydrazones
From the themed collection: 2019 Chemical Science HOT Article Collection
65 items

About this collection

This on-going web collection showcases all of the HOT Chemical Science articles published in 2019, as recommended by referees. Congratulations to all of the authors whose articles are featured.

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