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Themed collection Glycomics & Glycoproteomics: From Analytics to Function

15 items
Review Article

Identifying the targets and functions of N-linked protein glycosylation in Campylobacter jejuni

Virulence of Campylobacter jejuni is dependent on the ability to glycosylate membrane-associated proteins.

Graphical abstract: Identifying the targets and functions of N-linked protein glycosylation in Campylobacter jejuni
Research Article

Recombinant mucin-type proteins carrying LacdiNAc on different O-glycan core chains fail to support H. pylori binding

The β4-N-acetylgalactosaminyltransferase 3 (B4GALNT3) transfers GalNAc in a β1,4-linkage to GlcNAc forming the LacdiNAc (LDN) determinant on oligosaccharides.

Graphical abstract: Recombinant mucin-type proteins carrying LacdiNAc on different O-glycan core chains fail to support H. pylori binding
Research Article

β-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma

Genomic and structural analyses reveal that β-catenin/CBP signaling represses epidermal growth factor receptor (EGFR) N-glycan antennary fucosylation in oral cancer.

Graphical abstract: β-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma
Open Access Research Article

Choosing proper normalization is essential for discovery of sparse glycan biomarkers

In this work we assess the effect of different normalization methods on variable selection in an emerging field of glycomics.

Graphical abstract: Choosing proper normalization is essential for discovery of sparse glycan biomarkers
Research Article

Mass spectrometric analysis of core fucosylation and sequence variation in a human–camelid monoclonal antibody

ESI-MS fucosylation studies on an intact EG2-hFc monoclonal antibody reveal the presence of fucose on both Fc N-glycans.

Graphical abstract: Mass spectrometric analysis of core fucosylation and sequence variation in a human–camelid monoclonal antibody
Research Article

Quantitative capillary zone electrophoresis-mass spectrometry reveals the N-glycome developmental plan during vertebrate embryogenesis

The Xenopus laevis N-glycome undergoes massive reprogramming after the midblastula transition and the onset of neuronal development.

Graphical abstract: Quantitative capillary zone electrophoresis-mass spectrometry reveals the N-glycome developmental plan during vertebrate embryogenesis
Research Article

Rapid and sensitive glycan targeting by lectin-SERS assay

The fabrication of lectin-SERS nanotags and the assay designed for rapid glycoprotein identification and quantification.

Graphical abstract: Rapid and sensitive glycan targeting by lectin-SERS assay
Research Article

Robustness in glycosylation systems: effect of modified monosaccharides, acceptor decoys and azido sugars on cellular nucleotide-sugar levels and pattern of N-linked glycosylation

Chemical perturbation studies reveal robustness in glycosylation systems, based on comparison of LC-MS/MS quantification of cellular nucleotide-sugar levels with the observed N-linked glycan patterns.

Graphical abstract: Robustness in glycosylation systems: effect of modified monosaccharides, acceptor decoys and azido sugars on cellular nucleotide-sugar levels and pattern of N-linked glycosylation
Research Article

Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis

A high-throughput & efficient protocol for mass spectrometry-based glycomic and proteomic analysis.

Graphical abstract: Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis
Research Article

DIALib: an automated ion library generator for data independent acquisition mass spectrometry analysis of peptides and glycopeptides

Data Independent Acquisition (DIA) Mass Spectrometry (MS) workflows allow unbiased measurement of all detectable peptides from complex proteomes, but require ion libraries for interrogation of peptides of interest.

Graphical abstract: DIALib: an automated ion library generator for data independent acquisition mass spectrometry analysis of peptides and glycopeptides
Research Article

The effectiveness of filtering glycopeptide peak list files for Y ions

Novel software workflow for identifying additional glycopeptides in complex datasets.

Graphical abstract: The effectiveness of filtering glycopeptide peak list files for Y ions
Research Article

Novel O-linked sialoglycan structures in human urinary glycoproteins

Identification of new glycoforms for glycopeptides confidently assigned from primary database searches permitting the most common O-glycans only.

Graphical abstract: Novel O-linked sialoglycan structures in human urinary glycoproteins
Open Access Research Article

Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry

The developed workflow allows high throughput sample preparation for glycomics analysis.

Graphical abstract: Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry
Research Article

Mycobacterium bovis BCG infection alters the macrophage N-glycome

Macrophage glycosylation that is essential to the host-immune defense may be modulated by pathogens infection.

Graphical abstract: Mycobacterium bovis BCG infection alters the macrophage N-glycome
Open Access Research Article

Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome

We analyse and compare MUC7 O-glycosylation and inflammatory biomarkers in saliva from female patients with burning mouth syndrome (BMS) and gender/age-matched controls.

Graphical abstract: Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome
15 items

About this collection

This themed collection, Guest Edited by Professors Nicolle Packer, Morten Andersen and Daniel Kolarich, is dedicated to the glycomics and glycoproteomics research being carried out by scientists at the forefront of the field. The scope of this collection includes (but is not limited to) synthetic, analytical, technological and informatics advances as well as structural and functional aspects of protein glycosylation in biology.
Articles in this themed collection will be added below as soon as possible after they are published.
Please return to this page frequently to see the collection grow.

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