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Issue 5, 2019

Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome

Author affiliations

Abstract

We analysed and compared MUC7 O-glycosylation and inflammatory biomarkers in saliva from female patients with burning mouth syndrome (BMS) and gender/age-matched controls. Oligosaccharides from salivary MUC7 from BMS and controls were released. Inflammatory mediators were measured by multiplex proximity extension assay. Presence of sialyl-Lewisx (Si-Lex) epitope on MUC7 was confirmed using Western blot. MUC7 O-glycans and measured inflammatory biomarkers were found to be similar between BMS and controls. However, oligosaccharides sialyl-Lewisx (Si-Lex) was found to be reduced in samples from BMS patients. Positive correlation (combined patients and controls) was found between levels of C–C motif chemokine 19 (CCL-19) and the amount of core-2 oligosaccharides on MUC7 as well as fractalkine (CX3CL1) and level of sialylation. Patients with BMS were shown to represent a heterogeneous group in terms of inflammatory biomarkers. This indicates that BMS patients could be further stratified on the basis of low-level inflammation. The results furthermore indicate that reduced sialylation of MUC7, particularly Si-Lex, may be an important feature in patients with BMS. However, the functional aspects and potential involvement in immune regulation of Si-Lex remains unclear. Our data suggests a chemokine driven alteration of MUC7 glycosylation.

Graphical abstract: Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome

Supplementary files

Article information


Submitted
26 Mar 2019
Accepted
16 Jul 2019
First published
16 Jul 2019

This article is Open Access

Mol. Omics, 2019,15, 331-339
Article type
Research Article

Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome

S. Acharya, C. Jin, J. Bylund, Q. Shen, M. Kamali-Moghaddam, M. Jontell, A. Carlén and N. G. Karlsson, Mol. Omics, 2019, 15, 331 DOI: 10.1039/C9MO00061E

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