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Themed collection 2019 Emerging Investigators

39 items
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Contributors to the Emerging Investigators Issue 2019

From the themed collection: 2019 Emerging Investigators
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Target engagement approaches for pharmacological evaluation in animal models

We highlight recent applications of chemical biology approaches to measure target engagement of small molecules in animal models to support the nomination of clinical candidates.

Graphical abstract: Target engagement approaches for pharmacological evaluation in animal models
From the themed collection: 2019 Emerging Investigators
Feature Article

Photoswitchable peptides for spatiotemporal control of biological functions

Bioactive photoswitchable peptides as excellent optochemical tools for cellular processes.

Graphical abstract: Photoswitchable peptides for spatiotemporal control of biological functions
From the themed collection: 2019 Emerging Investigators
Feature Article

aza-BODIPY synthesis towards vis/NIR functional chromophores based on a Schiff base forming reaction protocol using lactams and heteroaromatic amines

The Schiff base forming reaction of lactams and heteroaromatic amines led to creation of a new class of aza-BODIPY analogues as visible and near infrared functional chromophores.

Graphical abstract: aza-BODIPY synthesis towards vis/NIR functional chromophores based on a Schiff base forming reaction protocol using lactams and heteroaromatic amines
From the themed collection: 2019 Emerging Investigators
Feature Article

The oxygen evolution reaction enabled by transition metal phosphide and chalcogenide pre-catalysts with dynamic changes

Dynamic morphological, structural and compositional changes will occur when transition metal phosphides and chalcogenides are used to catalyze the oxygen evolution reaction, which can substantially enhance their electrocatalytic performance.

Graphical abstract: The oxygen evolution reaction enabled by transition metal phosphide and chalcogenide pre-catalysts with dynamic changes
From the themed collection: 2019 Emerging Investigators
Feature Article

Tin-based nanomaterials: colloidal synthesis and battery applications

This Feature Article summarizes the recent advances in the colloidal synthesis of tin-based nanomaterials and their electrochemical properties in alkali-ion batteries.

Graphical abstract: Tin-based nanomaterials: colloidal synthesis and battery applications
From the themed collection: 2019 Emerging Investigators
Feature Article

Recent advances in the catalytic asymmetric alkylation of stabilized phosphorous ylides

The Wittig reaction is a reliable method for synthesizing alkenes from phosphorous ylides (P-ylides) and carbonyls, and is thus widely applied in medicine and pharmaceutical production.

Graphical abstract: Recent advances in the catalytic asymmetric alkylation of stabilized phosphorous ylides
From the themed collection: 2019 Emerging Investigators
Feature Article

Redefining the photo-stability of common fluorophores with triplet state quenchers: mechanistic insights and recent updates

Various strategies for TSQ-induced fluorophore stabilization and their application in sm-FRET as well as in super-resolution imaging microscopy are thoroughly reviewed.

Graphical abstract: Redefining the photo-stability of common fluorophores with triplet state quenchers: mechanistic insights and recent updates
From the themed collection: 2019 Emerging Investigators
Feature Article

Novel metal–organic framework materials: blends, liquids, glasses and crystal–glass composites

This Feature Article reviews a range of amorphisation mechanisms of Metal–Organic Frameworks (MOFs) and presents recent advances to produce novel MOF materials including porous MOF glasses, MOF crystal–glass composites, flux melted MOF glasses and blended zeolitic imidazolate framework glasses.

Graphical abstract: Novel metal–organic framework materials: blends, liquids, glasses and crystal–glass composites
From the themed collection: 2019 Emerging Investigators
Communication

Artificial β-propeller protein-based hydrolases

We investigated symmetrical β-propeller protein scaffolds as artificial hydrolases and discovered their catalytic mechanism to be centred around a threonine–histidine dyad.

Graphical abstract: Artificial β-propeller protein-based hydrolases
From the themed collection: 2019 Emerging Investigators
Communication

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells.

Graphical abstract: Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery
From the themed collection: 2019 Emerging Investigators
Communication

Thickness dependent thermal stability of 2D gallenene

Freestanding 2D metallic gallenene exhibits remarkable stability when the thickness is three atomic layers.

Graphical abstract: Thickness dependent thermal stability of 2D gallenene
From the themed collection: 2019 Emerging Investigators
Communication

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

Polysulfides, potential signalling molecules, were synthesised and then found and explored for the first time in yeast.

Graphical abstract: Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae
From the themed collection: 2019 Emerging Investigators
Communication

Bifunctional electrocatalysis for CO2 reduction via surface capping-dependent metal–oxide interactions

Cetyltrimethylammonium bromide capping on Au renders desirable chemical interactions with SnO2, enabling selective bifunctional CO2 electroreduction.

Graphical abstract: Bifunctional electrocatalysis for CO2 reduction via surface capping-dependent metal–oxide interactions
From the themed collection: 2019 Emerging Investigators
Communication

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

A Cu2+ complex for bimodal imaging of cellular hypoxia using 19F magnetic resonance and fluorescence.

Graphical abstract: A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence
From the themed collection: 2019 Emerging Investigators
Communication

Using ligands to control reactivity, size and phase in the colloidal synthesis of WSe2 nanocrystals

Colloidal synthesis enables size- and phase-tuning of WSe2 nanocrystals.

Graphical abstract: Using ligands to control reactivity, size and phase in the colloidal synthesis of WSe2 nanocrystals
From the themed collection: 2019 Emerging Investigators
Open Access Communication

Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion

We report the synthesis of superhydrophobic two-dimensional (2D) transition metal dichalcogenides by modulation of the degree of atomic defects. The presence of atomic vacancies in 2D molybdenum disulfide (MoS2) nanoassemblies dictated hydrophilic-to-hydrophobic transition and subsequent cell adhesion.

Graphical abstract: Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion
From the themed collection: 2019 Emerging Investigators
Communication

Cross-linked porous polyurethane materials featuring dodecaborate clusters as inorganic polyol equivalents

A perhydroxylated dodecaborate cluster acts as an inorganic polyol to produce cross-linked polyurethanes, which confers a porous structure and enhanced thermal stability compared to analogous polymers produced from carbon-based polyols.

Graphical abstract: Cross-linked porous polyurethane materials featuring dodecaborate clusters as inorganic polyol equivalents
From the themed collection: 2019 Emerging Investigators
Open Access Communication

Mechanism and regioselectivity of the anionic oxidative rearrangement of 1,3-diketones towards all-carbon quaternary carboxylates

The oxidative rearrangement of 1,3-diketones is an underexplored alternative to enolate chemistry in the synthesis of all-carbon quaternary carboxylates. Mechanistic understanding enabled the discovery of a faster and more effective reaction.

Graphical abstract: Mechanism and regioselectivity of the anionic oxidative rearrangement of 1,3-diketones towards all-carbon quaternary carboxylates
From the themed collection: 2019 Emerging Investigators
Communication

Base-catalysed reductive relay hydroboration of allylic alcohols with pinacolborane to form alkylboronic esters

A novel reductive relay hydroboration of allylic alcohols with pinacolborane using nBuLi as an efficient initiator is reported.

Graphical abstract: Base-catalysed reductive relay hydroboration of allylic alcohols with pinacolborane to form alkylboronic esters
From the themed collection: 2019 Emerging Investigators
Communication

Protein film electrochemical EPR spectroscopy as a technique to investigate redox reactions in biomolecules

Direct potential control of protein redox centres for both electrochemical and EPR characterisation.

Graphical abstract: Protein film electrochemical EPR spectroscopy as a technique to investigate redox reactions in biomolecules
From the themed collection: 2019 Emerging Investigators
Communication

Tuning of the flexibility in metal–organic frameworks based on pendant arm macrocycles

An isostructural series of flexible MOFs based on pendant arm macrocycles was developed to tune flexibility depending on functional groups.

Graphical abstract: Tuning of the flexibility in metal–organic frameworks based on pendant arm macrocycles
From the themed collection: 2019 Emerging Investigators
Communication

Resistive switching in an organic supramolecular semiconducting ferroelectric

The combination of switchable dipolar side groups and the semiconducting core leads to a material showing continuous tunability from injection- to bulk-limited conductivity modulation.

Graphical abstract: Resistive switching in an organic supramolecular semiconducting ferroelectric
From the themed collection: 2019 Emerging Investigators
Communication

The polymorphism of porphyrin 2D assemblies at the liquid–graphite interface: the effect of a polar solvent additive and a flexible spacer on the face-on and edge-on type molecular arrangements

The edge-on type 2D self-assembly can be selectively formed by managing hydrogen bonding interactions at the liquid–solid interface.

Graphical abstract: The polymorphism of porphyrin 2D assemblies at the liquid–graphite interface: the effect of a polar solvent additive and a flexible spacer on the face-on and edge-on type molecular arrangements
From the themed collection: 2019 Emerging Investigators
Communication

Multi-component heteroarene couplings via polarity-reversed radical cascades

A unified strategy enables multi-component radical addition cascades to couple alkenes, heteroarenes, and various radicals, including N3, P(O)R2, and CF3.

Graphical abstract: Multi-component heteroarene couplings via polarity-reversed radical cascades
From the themed collection: 2019 Emerging Investigators
Communication

Understanding the strain effect of Au@Pd nanocatalysts by in situ surface-enhanced Raman spectroscopy

A gap-mode configuration was developed for the in situ SERS study of the structure–activity relationship of Au@Pd core–shell nanocatalysts, which show much better performance in the selective oxidation of benzyl alcohol compared to Pd.

Graphical abstract: Understanding the strain effect of Au@Pd nanocatalysts by in situ surface-enhanced Raman spectroscopy
From the themed collection: 2019 Emerging Investigators
Communication

Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

At high local DNA concentrations, a photoactive Ru(II) complex forms photo-adducts more rapidly and with reduced promiscuity.

Graphical abstract: Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA
From the themed collection: 2019 Emerging Investigators
Open Access Communication

Cooperative activation of X–H (X = H, C, O, N) bonds by a Pt(0)/Ag(I) metal-only Lewis pair

Metal-only Lewis pairs made of Pt(0)/Ag(I) combinations have been previously reported, but their cooperative reactivity remains unexplored.

Graphical abstract: Cooperative activation of X–H (X = H, C, O, N) bonds by a Pt(0)/Ag(i) metal-only Lewis pair
From the themed collection: 2019 Emerging Investigators
Communication

A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds

A palladium/norbornene cooperative catalysis promoted annulation involving an ortho-C–H amination and intramolecular Heck cascade between aryl iodides and functionalized amination reagents is reported, thereby providing a highly convergent access to the unique N-containing bridged scaffolds: hexahydro-2,6-methano-1-benzazocine.

Graphical abstract: A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds
From the themed collection: 2019 Emerging Investigators
Communication

Facile electrochemical synthesis of ultrathin iron oxyhydroxide nanosheets for the oxygen evolution reaction

Ultrathin iron oxyhydroxide nanosheets were synthesised by multiple potential cyclings on thermally annealed iron foils, acting as an efficient oxygen evolution electrocatalyst.

Graphical abstract: Facile electrochemical synthesis of ultrathin iron oxyhydroxide nanosheets for the oxygen evolution reaction
From the themed collection: 2019 Emerging Investigators
Communication

Inter-ligand energy transfer in dye chromophores attached to high bandgap SiO2 nanoparticles

Simple artificial light harvesting networks can be created by the covalent attachment of organic chromophores to silicon dioxide nanoparticles.

Graphical abstract: Inter-ligand energy transfer in dye chromophores attached to high bandgap SiO2 nanoparticles
From the themed collection: 2019 Emerging Investigators
Open Access Communication

Switching the enantioselectivity of nanoporous host materials by light

A chiral photoswitchable nanoporous material with remote-controllable enantioselective adsorption capacity is presented.

Graphical abstract: Switching the enantioselectivity of nanoporous host materials by light
From the themed collection: 2019 Emerging Investigators
Communication

[2+2] Halogen-bonded boxes employing azobenzenes

Herein, we report the synthesis and crystal structures of three [2+2] supramolecular boxes assembled by halogen bonding.

Graphical abstract: [2+2] Halogen-bonded boxes employing azobenzenes
Communication

Supramolecular calix[4]pyrrole polymers from a complementary pair of homoditopic host–guest molecules

Calix[4]pyrrole based thermoresponsive supramolecular polymers were demonstrated by using a complementary pair of homoditopic host and guest molecules.

Graphical abstract: Supramolecular calix[4]pyrrole polymers from a complementary pair of homoditopic host–guest molecules
From the themed collection: 2019 Emerging Investigators
Communication

Size dependent selectivity of Cu nano-octahedra catalysts for the electrochemical reduction of CO2 to CH4

Octahedral Cu nanocrystals in the size range of 75–310 nm are synthesized and investigated for electrochemical CO2 reduction.

Graphical abstract: Size dependent selectivity of Cu nano-octahedra catalysts for the electrochemical reduction of CO2 to CH4
From the themed collection: 2019 Emerging Investigators
Communication

Seleno-analogues of pentlandites (Fe4.5Ni4.5S8−YSeY, Y = 1–6): tuning bulk Fe/Ni sulphoselenides for hydrogen evolution

A series of hitherto unprecedented seleno-pentlandites (Fe4.5Ni4.5S8-YSeY) and their catalytic activity in the hydrogen evolution reaction is presented.

Graphical abstract: Seleno-analogues of pentlandites (Fe4.5Ni4.5S8−YSeY, Y = 1–6): tuning bulk Fe/Ni sulphoselenides for hydrogen evolution
From the themed collection: 2019 Emerging Investigators
Communication

Tandem catalysis by ultrathin metal–organic nanosheets formed through post-synthetic functionalisation of a layered framework

Covalent post-synthetic functionalisation of layered metal–organic frameworks is demonstrated as a new approach to forming ultrathin nanosheets for use in catalysis.

Graphical abstract: Tandem catalysis by ultrathin metal–organic nanosheets formed through post-synthetic functionalisation of a layered framework
From the themed collection: 2019 Emerging Investigators
Communication

BiCl3-Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF2PO(OEt)2 reagent

A general access to challenging and unprecedented C(sp)–, C(sp2)– and C(sp3)–SCF2PO(OEt)2 bonds via a BiCl3 mediated transformation.

Graphical abstract: BiCl3-Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF2PO(OEt)2 reagent
From the themed collection: 2019 Emerging Investigators
Communication

Tunneling and thermoelectric characteristics of N-heterocyclic carbene-based large-area molecular junctions

Tunneling and thermoelectric characteristics of NHC-based large-area junctions were demonstrated for the first time.

Graphical abstract: Tunneling and thermoelectric characteristics of N-heterocyclic carbene-based large-area molecular junctions
From the themed collection: 2019 Emerging Investigators
39 items

About this collection

Now on its 9th year, this annual special issue showcases research carried out by internationally recognised, up-and-coming scientists in the early stages of their independent careers, and who are making outstanding contributions to their respective fields!

Join us in celebrating their contributions!

New articles will be added to this collection as they are published.

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