Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

Lisa I. Pilkington; Rebecca C. Deed; Katie Parish-Virtue; Chien-Wei Huang; Michelle E. Walker; Vladimir Jiranek; David Barker; Bruno Fedrizzi

doi:10.1039/C9CC03020D

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Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae†

Lisa I. Pilkington,

*^a Rebecca C. Deed,

^ab Katie Parish-Virtue,

^a Chien-Wei Huang,^a Michelle E. Walker,

^c Vladimir Jiranek,^c David Barker

*^a and Bruno Fedrizzi

*^a

Author affiliations

* Corresponding authors

^a School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland 1142, New Zealand
E-mail: lisa.pilkington@auckland.ac.nz, d.barker@auckland.ac.nz, b.fedrizzi@auckland.ac.nz

^b School of Biological Sciences, The University of Auckland, 3A Symonds St, Auckland 1142, New Zealand

^c Department of Wine and Food Science, The University of Adelaide, Wine Innovation Central, Adelaide, SA 5064, Australia

Abstract

New evidence on the role of H₂S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.

This article is part of the themed collection: 2019 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/C9CC03020D
Article type: Communication
Submitted: 18 Apr 2019
Accepted: 18 Jun 2019
First published: 19 Jun 2019

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Chem. Commun., 2019,55, 8868-8871

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Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

L. I. Pilkington, R. C. Deed, K. Parish-Virtue, C. Huang, M. E. Walker, V. Jiranek, D. Barker and B. Fedrizzi, Chem. Commun., 2019, 55, 8868 DOI: 10.1039/C9CC03020D

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Chemical Communications

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae†

Abstract

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Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

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