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Issue 60, 2019
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Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

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Abstract

New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.

Graphical abstract: Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

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Supplementary files

Article information


Submitted
18 Apr 2019
Accepted
18 Jun 2019
First published
19 Jun 2019

Chem. Commun., 2019,55, 8868-8871
Article type
Communication

Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae

L. I. Pilkington, R. C. Deed, K. Parish-Virtue, C. Huang, M. E. Walker, V. Jiranek, D. Barker and B. Fedrizzi, Chem. Commun., 2019, 55, 8868 DOI: 10.1039/C9CC03020D

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