Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 60, 2019

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Author affiliations

Abstract

We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

Graphical abstract: A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Supplementary files

Article information


Submitted
15 Jan 2019
Accepted
13 Jun 2019
First published
13 Jun 2019

Chem. Commun., 2019,55, 8860-8863
Article type
Communication

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

R. T. Kadakia, D. Xie, D. Martinez, M. Yu and E. L. Que, Chem. Commun., 2019, 55, 8860 DOI: 10.1039/C9CC00375D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements