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Issue 5, 2020
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Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

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Abstract

We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants. These studies have provided expedient synthetic access to streamlined adjuvant-active saponins and yielded molecular-level insights into saponin conformation that correlated with their in vivo adjuvant activities.

Graphical abstract: Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

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Supplementary files

Article information


Submitted
04 Oct 2019
Accepted
12 Nov 2019
First published
12 Dec 2019

This article is Open Access

Chem. Commun., 2020,56, 719-722
Article type
Communication

Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

M. Ghirardello, A. Ruiz-de-Angulo, N. Sacristan, D. Barriales, J. Jiménez-Barbero, A. Poveda, F. Corzana, J. Anguita and A. Fernández-Tejada, Chem. Commun., 2020, 56, 719 DOI: 10.1039/C9CC07781B

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