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Themed collection Chemistry for Medicine: Special Collection for RSC Advances

39 items
Open Access Review Article

Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

This article reviews antibacterial surface strategies based on reactive plasma chemistry, focusing on how plasma-assisted processing of natural antimicrobial agents can produce antifouling and antibacterial materials for biomedical devices.

Graphical abstract: Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification
Review Article

Bioapplication of graphene oxide derivatives: drug/gene delivery, imaging, polymeric modification, toxicology, therapeutics and challenges

This review article summarizes the latest progress in research regarding bioapplications of graphene oxide derivatives and provides expert opinions on strategies for overcoming the current challenges.

Graphical abstract: Bioapplication of graphene oxide derivatives: drug/gene delivery, imaging, polymeric modification, toxicology, therapeutics and challenges
Review Article

Metal-free domino one-pot protocols for quinoline synthesis

Metal-free domino one-pot protocols for quinoline synthesis have been reviewed.

Graphical abstract: Metal-free domino one-pot protocols for quinoline synthesis
Review Article

Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels

This article reviews recent advances in the crosslinking chemistries of biomimetic hydrogels prepared from PEG-based macromers.

Graphical abstract: Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels
Review Article

Plasmon-enhanced light harvesting: applications in enhanced photocatalysis, photodynamic therapy and photovoltaics

This review article summarizes the recent progress on surface plasmon-enhanced light harvesting and its applications toward enhanced photocatalysis, photodynamic therapy, chemical transformations and photovoltaics.

Graphical abstract: Plasmon-enhanced light harvesting: applications in enhanced photocatalysis, photodynamic therapy and photovoltaics
Review Article

Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications

Oxidative stress, a result of an overproduction and accumulation of free radicals, is the leading cause of several degenerative diseases such as cancer, atherosclerosis, cardiovascular diseases, ageing and inflammatory diseases.

Graphical abstract: Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications
Review Article

Modified biopolymer-dextrin based crosslinked hydrogels: application in controlled drug delivery

This review describes hydrogels and their classifications along with the synthesis and properties of biopolymer-dextrin based crosslinked hydrogels towards potential application in controlled drug delivery.

Graphical abstract: Modified biopolymer-dextrin based crosslinked hydrogels: application in controlled drug delivery
Review Article

Toward point-of-care diagnostics with consumer electronic devices: the expanding role of nanoparticles

A review of the role that nanoparticles can play in point-of-care diagnostics that utilize consumer electronic devices such as cell phones and smartphones for readout, including an overview of important concepts and examples from the literature.

Graphical abstract: Toward point-of-care diagnostics with consumer electronic devices: the expanding role of nanoparticles
Review Article

Fluorescent graphene quantum dots for biosensing and bioimaging

Graphene quantum dots with unique properties have great potential applications for biosensing and bioimaging.

Graphical abstract: Fluorescent graphene quantum dots for biosensing and bioimaging
Review Article

Understanding cancer and the anticancer activities of naphthoquinones – a review

Naphthoquinone moieties are present in drugs such as doxorubicin which are used clinically to treat solid cancers.

Graphical abstract: Understanding cancer and the anticancer activities of naphthoquinones – a review
Review Article

Biological and pharmacological activities of amaryllidaceae alkaloids

This review discusses the recent developments on biological and pharmacological activities of amaryllidaceae alkaloids with IC50 or EC50 values since 2005, supporting the potential therapeutic possibilities for the use of these compounds.

Graphical abstract: Biological and pharmacological activities of amaryllidaceae alkaloids
Review Article

Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities.

Graphical abstract: Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics
Review Article

Recent advances in the synthesis, characterization, and biomedical applications of ultrasmall thiolated silver nanoclusters

Recent advances in characterizing ultrasmall thiolated Ag nanoclusters, showing their optical and biological properties, and size, composition, and structure information.

Graphical abstract: Recent advances in the synthesis, characterization, and biomedical applications of ultrasmall thiolated silver nanoclusters
Review Article

Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview

This review covers the synthesis of achiral diarylmethanols, diaryl and triarylmethanes and the bioactivities of diaryl and triarylmethanes during 1995 to 2013.

Graphical abstract: Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview
Review Article

Bioimaging based on fluorescent carbon dots

Herein, we review the bioimaging application of three kinds of fluorescent carbon dots (CDs), namely, graphene quantum dots (GQDs), carbon nanodots (CNDs) and polymer dots (PDs).

Graphical abstract: Bioimaging based on fluorescent carbon dots
Review Article

Recent advances in the synthesis of quinolines: a review

This review article gives information about the recent advances in the synthesis of quinoline derivatives by various eco-friendly, green and clean protocols.

Graphical abstract: Recent advances in the synthesis of quinolines: a review
Review Article

Mesoporous silica-based nanodevices for biological applications

This review highlights and addresses issues related to research on the development of mesoporous silica nanomaterials (MSNs) based nanodevices for biological applications.

Graphical abstract: Mesoporous silica-based nanodevices for biological applications
Review Article

Fabrication, modification, and biomedical applications of anodized TiO2 nanotube arrays

Recent research activities on the surface modification and biomedical applications of TiO2 NTAs are reviewed.

Graphical abstract: Fabrication, modification, and biomedical applications of anodized TiO2 nanotube arrays
Review Article

Polymeric micelles as drug delivery vehicles

Though much progress has been made in drug delivery systems, the design of a suitable carrier for the delivery of hydrophobic drugs is still a major challenge for researchers.

Graphical abstract: Polymeric micelles as drug delivery vehicles
Review Article

Nucleic acid therapeutics: basic concepts and recent developments

Nucleic acid based therapeutics comprising chemically modified oligonucleotides are the current focus of clinical research for the treatment of various diseases.

Graphical abstract: Nucleic acid therapeutics: basic concepts and recent developments
Review Article

Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery

This review considers the importance of surface modifications of mesoporous nanoparticles and their biological consequences.

Graphical abstract: Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery
Review Article

Carbon-based quantum dots for fluorescence imaging of cells and tissues

On recent advances in the development of carbon-based quantum dots, carbon dots in particular, for fluorescence imaging of cells and tissues.

Graphical abstract: Carbon-based quantum dots for fluorescence imaging of cells and tissues
Review Article

Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery

The chemical properties of curcumin as well as its proposed mechanism of action as an anti-cancer therapeutic are reviewed. Recent approaches to curcumin delivery are described.

Graphical abstract: Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery
Communication

Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

Dual-functionality carbon dots with both anti-microbial and gene transfection abilities were developed and their properties elaborated in this paper.

Graphical abstract: Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties
Communication

Alginate–peptide amphiphile core–shell microparticles as a targeted drug delivery system

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor.

Graphical abstract: Alginate–peptide amphiphile core–shell microparticles as a targeted drug delivery system
Communication

Mesoporous silica nanoparticles enhance the cytotoxicity of curcumin

Curcumin encapsulated mesoporous silica nanoparticle (MSN) displaying higher cytotoxic for treatment in skin cancer cell line compared to pure curcumin.

Graphical abstract: Mesoporous silica nanoparticles enhance the cytotoxicity of curcumin
Paper

PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

This work represents the first time that poly(PEG/PPG/PLA urethane) has been used for the delivery of drugs to tumours in vivo and the encouraging results point to the potential for further development of this thermogel platform for anti-cancer applications.

Graphical abstract: PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma
Paper

Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications

Highly active antibacterial poly(N,N-dimethylaminoethyl methacrylate)-block-poly(L-lactic acid)-block-poly(N,N-dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized.

Graphical abstract: Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications
Paper

Effects of the i-motif DNA loop on the fluorescence of silver nanoclusters

The loop sequences in i-motif DNA templates are well correlated with the fluorescence of the prepared Ag clusters.

Graphical abstract: Effects of the i-motif DNA loop on the fluorescence of silver nanoclusters
Paper

Novel three-dimensional, conducting, biocompatible, porous, and elastic polyaniline-based scaffolds for regenerative therapies

Fabrication of two novel three-dimensional, conducting, biocompatible, porous, and elastic scaffolds composed of hyperbranched aliphatic polyesters, polyaniline, and poly(ε-caprolactone) for tissue engineering applications.

Graphical abstract: Novel three-dimensional, conducting, biocompatible, porous, and elastic polyaniline-based scaffolds for regenerative therapies
Paper

Design and development of a novel cellulose/γ-Fe2O3/Ag nanocomposite: a potential green catalyst and antibacterial agent

A new cellulose-based nanocomposite was synthesized, characterization and used for the synthesis of imidazoles and α-aminonitriles, and antibacterial property was investigated.

Graphical abstract: Design and development of a novel cellulose/γ-Fe2O3/Ag nanocomposite: a potential green catalyst and antibacterial agent
Paper

Osteoblastic cell responses and antibacterial efficacy of Cu/Zn co-substituted hydroxyapatite coatings on pure titanium using electrodeposition method

Effective physiological bone integration and absence of bacterial infection are essential for a successful orthopaedic or dental implant.

Graphical abstract: Osteoblastic cell responses and antibacterial efficacy of Cu/Zn co-substituted hydroxyapatite coatings on pure titanium using electrodeposition method
Paper

ZnO/Ag micro/nanospheres with enhanced photocatalytic and antibacterial properties synthesized by a novel continuous synthesis method

A continuous concentric impinging stream method was used for preparing ZnO/Ag MNSs, which possessed excellent photocatalytic and antibacterial activities.

Graphical abstract: ZnO/Ag micro/nanospheres with enhanced photocatalytic and antibacterial properties synthesized by a novel continuous synthesis method
Paper

Cyto and genotoxicities of graphene oxide and reduced graphene oxide sheets on spermatozoa

The interaction of graphene with spermatozoa resulted in trapping, oxidative stress, mitochondria damage, DNA damage and finally death of the spermatozoa.

Graphical abstract: Cyto and genotoxicities of graphene oxide and reduced graphene oxide sheets on spermatozoa
Paper

Bifunctional TiO2/Ag3PO4/graphene composites with superior visible light photocatalytic performance and synergistic inactivation of bacteria

Schematic representation of the synthetic strategy for TiO2/Ag3PO4/GR composites.

Graphical abstract: Bifunctional TiO2/Ag3PO4/graphene composites with superior visible light photocatalytic performance and synergistic inactivation of bacteria
Paper

Nanofibrous electroactive scaffolds from a chitosan-grafted-aniline tetramer by electrospinning for tissue engineering

Synthesis of chitosan–aniline tetramer and its electroactive nanofibrous scaffolds enhanced cell adhesion and proliferation of C2C12 myoblasts.

Graphical abstract: Nanofibrous electroactive scaffolds from a chitosan-grafted-aniline tetramer by electrospinning for tissue engineering
Paper

Aggregation-induced emission dye based luminescent silica nanoparticles: facile preparation, biocompatibility evaluation and cell imaging applications

Facile encapsulation of aggregation-induced emission dye into silica nanoparticles via a modified Stöber method was developed. Cell imaging applications of such luminescent silica nanoparticles were further investigated.

Graphical abstract: Aggregation-induced emission dye based luminescent silica nanoparticles: facile preparation, biocompatibility evaluation and cell imaging applications
Open Access Paper

Size-controlled silver nanoparticles synthesized over the range 5–100 nm using the same protocol and their antibacterial efficacy

Size-specific antibacterial activity of 5–100 nm silver nanoparticles synthesized using a novel co-reduction approach.

Graphical abstract: Size-controlled silver nanoparticles synthesized over the range 5–100 nm using the same protocol and their antibacterial efficacy
Paper

PVDF film tethered with RGD-click-poly(glycidyl methacrylate) brushes by combination of direct surface-initiated ATRP and click chemistry for improved cytocompatibility

PVDF film was functionalized by grafting of RGD-click-poly(glycidyl methacrylate) brushes using the combination of direct surface-initiated ATRP and alkyne-azide click reaction for improved cell adhesion and proliferation.

Graphical abstract: PVDF film tethered with RGD-click-poly(glycidyl methacrylate) brushes by combination of direct surface-initiated ATRP and click chemistry for improved cytocompatibility
39 items

About this collection

This collection presents a number of contributions from the field "Chemistry for Medicine", published in RSC Advances in the years 2014-2015. They cover a wide range of topics, from fundamental research on the preparation of new chemical compounds and materials to various biological and medical applications. The synthesis and modification of chemical compounds as pharmaceuticals is a traditionally strong field of synthetic chemistry. Biomaterials and their surface modification play an increasing role, including their coupling to electronic devices for sensing. A special focus lies on nanoparticles of different chemical natures (e.g. silica, carbon nanotubes, graphene, polymers) for biomedical applications like drug delivery, imaging, and antibacterial devices. Scaffolds for tissue engineering and regenerative therapies are emerging systems for future cell-based therapies. 
All articles in this collection are free to access until 17th March 2017.

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