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Issue 50, 2016
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PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

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Abstract

A thermogelling poly(ester urethane) comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(lactic acid) (PLA) blocks was synthesized. Drug release studies of the thermogel were carried out using paclitaxel (PTX). The release rate of the drug can be achieved by changing the concentration of the gel, greatly prolonging the release and elimination times to afford long-term effects. The thermogels showed very low toxicity on HEK293 cells. A nude mice model of hepatocellular carcinoma was developed and intratumoural injection of drug-loaded thermogel showed that PTX-loaded thermogel effectively inhibited the growth of tumours.

Graphical abstract: PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

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Publication details

The article was received on 28 Mar 2016, accepted on 25 Apr 2016 and first published on 26 Apr 2016


Article type: Paper
DOI: 10.1039/C6RA08022G
Citation: RSC Adv., 2016,6, 44506-44513
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    PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

    Y. Wu, H. Wang, Y. Qiu and X. J. Loh, RSC Adv., 2016, 6, 44506
    DOI: 10.1039/C6RA08022G

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