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Issue 60, 2015
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Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

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Abstract

Strategies that confine antibacterial and/or antifouling property to the surface of the implant, by modifying the surface chemistry and morphology or by encapsulating the material in an antibiotic-loaded coating, are most promising as they do not alter bulk integrity of the material. Among them, plasma-assisted modification and catechol chemistry stand out for their ability to modify a wide range of substrates. By controlling processing parameters, plasma environment can be used for surface nano structuring, chemical activation, and deposition of biologically active and passive coatings. Catechol chemistry can be used for material-independent, highly-controlled surface immobilisation of active molecules and fabrication of biodegradable drug-loaded hydrogel coatings. In this article, we comprehensively review the role plasma-assisted processing and catechol chemistry can play in combating bacterial colonisation on medically relevant coatings, and how these strategies can be coupled with the use of natural antimicrobial agents to produce synthetic antibiotic-free antibacterial surfaces.

Graphical abstract: Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

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Publication details

The article was received on 30 Dec 2014, accepted on 21 May 2015 and first published on 21 May 2015


Article type: Review Article
DOI: 10.1039/C4RA17244B
Citation: RSC Adv., 2015,5, 48739-48759
  • Open access: Creative Commons BY license
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    Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

    K. Bazaka, M. V. Jacob, W. Chrzanowski and K. Ostrikov, RSC Adv., 2015, 5, 48739
    DOI: 10.1039/C4RA17244B

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