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Issue 22, 2015
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Osteoblastic cell responses and antibacterial efficacy of Cu/Zn co-substituted hydroxyapatite coatings on pure titanium using electrodeposition method

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Abstract

Effective physiological bone integration and absence of bacterial infection are essential for a successful orthopaedic or dental implant. This work elucidated the antibacterial efficacy and cytocompatibility of an electroplated Cu(II) and Zn(II) co-substituted hydroxyapatite (HAP) (i.e., ZnCuHAP) coating on commercially pure titanium (Ti-cp). To improve the antibacterial property of pure HAP, Cu2+ was substituted into its structure. Simultaneously, Zn2+ is co-substituted as a secondary material into CuHAP to offset the potential cytotoxicity of Cu, because an elevated Cu concentration is toxic. The as-deposited coatings were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Co-doping of Zn2+ and Cu2+ into HAP reduced the porosity, resulting in a denser coating. The Zn2+ and Cu2+ ions were homogenously co-deposited into HAP films. Potentiodynamic polarisation test revealed that the ZnCuHAP covered coating provided good barrier characteristics and achieved superior corrosion protection for Ti substrates. The as-prepared ZnCuHAP coating was found to be highly effective against Escherichia coli in vitro. In vitro biocompatibility tests and MTT were employed to assess the cytotoxicity of ZnCuHAP coating with osteoblast-like MC3T3-E1 cells. No adverse effect or cytotoxicity on osteoblasts by Zn/Cu addition was observed, revealing that the co-substitution of Zn in CuHAP efficiently offsets the adverse effects of Cu and improves the performance compared with that of pure HAP.

Graphical abstract: Osteoblastic cell responses and antibacterial efficacy of Cu/Zn co-substituted hydroxyapatite coatings on pure titanium using electrodeposition method

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Publication details

The article was received on 10 Oct 2014, accepted on 03 Feb 2015 and first published on 03 Feb 2015


Article type: Paper
DOI: 10.1039/C4RA12118J
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 17076-17086
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    Osteoblastic cell responses and antibacterial efficacy of Cu/Zn co-substituted hydroxyapatite coatings on pure titanium using electrodeposition method

    Y. Huang, X. Zhang, H. Mao, T. Li, R. Zhao, Y. Yan and X. Pang, RSC Adv., 2015, 5, 17076
    DOI: 10.1039/C4RA12118J

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